Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates

Prechter A, Gröger H, Heinrich MR (2012)
Organic & Biomolecular Chemistry 10(17).

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The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated using benzylamine as amine component. The products obtained from this biotransformation in high enantiomeric purity can serve as valuable precursors for various amino alcohols, as exemplified by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine.
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Prechter A, Gröger H, Heinrich MR. Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Organic & Biomolecular Chemistry. 2012;10(17).
Prechter, A., Gröger, H., & Heinrich, M. R. (2012). Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Organic & Biomolecular Chemistry, 10(17).
Prechter, A., Gröger, H., and Heinrich, M. R. (2012). Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Organic & Biomolecular Chemistry 10.
Prechter, A., Gröger, H., & Heinrich, M.R., 2012. Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Organic & Biomolecular Chemistry, 10(17).
A. Prechter, H. Gröger, and M.R. Heinrich, “Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates”, Organic & Biomolecular Chemistry, vol. 10, 2012.
Prechter, A., Gröger, H., Heinrich, M.R.: Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Organic & Biomolecular Chemistry. 10, (2012).
Prechter, Agnes, Gröger, Harald, and Heinrich, Markus R. “Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates”. Organic & Biomolecular Chemistry 10.17 (2012).
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Synthesis of enantioenriched azo compounds: organocatalytic Michael addition of formaldehyde N-tert-butyl hydrazone to nitroalkenes.
Monge D, Daza S, Bernal P, Fernandez R, Lassaletta JM., Org. Biomol. Chem. 11(2), 2013
PMID: 23172574

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