Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis

Viefhues M, Eichhorn R, Fredrich E, Regtmeier J, Anselmetti D (2012)
Lab on a Chip 12(3): 485-494.

Journal Article | Published | English

No fulltext has been uploaded

Abstract
Mixing and demixing (separation) are essential tasks in microfluidic devices, which seem to be contrary in nature. Accordingly, completely different strategies and devices are usually employed for their realization. We here present a microfluidic device which is capable of performing both these tasks as it can be operated in either mixing or demixing mode. The mixing and demixing processes are reversible and are accomplished by continuous operation of the device. An asymmetric S-shaped ridge extends over the full width of a microfluidic channel (200 mu m) creating a constriction of 620 nm in height with an aspect ratio of 1 : 500. Appropriate AC and DC voltages generate electrodeless dielectrophoresis at the constriction as well as (linear) electrokinetic driving forces along the channel. These de/mixing parameters can be adapted in real time in such a way that continuous separation and mixing efficiencies of 85-100% can be achieved. As a proof of concept we demonstrate continuous mixing and demixing of polystyrene nanoparticles (20 and 100 nm). The experimental results are complemented by numerical simulations illustrating the particles' motion under the influence of the electrokinetic effects and thermal noise (diffusion). The monolithic one-step fabrication process by soft lithography (with PDMS in our case) will make integration and combination of several mixing and demixing functions into a more complex lab-on-a-chip device possible.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Viefhues M, Eichhorn R, Fredrich E, Regtmeier J, Anselmetti D. Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip. 2012;12(3):485-494.
Viefhues, M., Eichhorn, R., Fredrich, E., Regtmeier, J., & Anselmetti, D. (2012). Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip, 12(3), 485-494.
Viefhues, M., Eichhorn, R., Fredrich, E., Regtmeier, J., and Anselmetti, D. (2012). Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip 12, 485-494.
Viefhues, M., et al., 2012. Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip, 12(3), p 485-494.
M. Viefhues, et al., “Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis”, Lab on a Chip, vol. 12, 2012, pp. 485-494.
Viefhues, M., Eichhorn, R., Fredrich, E., Regtmeier, J., Anselmetti, D.: Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip. 12, 485-494 (2012).
Viefhues, Martina, Eichhorn, Ralf, Fredrich, Eugenie, Regtmeier, Jan, and Anselmetti, Dario. “Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis”. Lab on a Chip 12.3 (2012): 485-494.
This data publication is cited in the following publications:
This publication cites the following data publications:

6 Citations in Europe PMC

Data provided by Europe PubMed Central.

Rapid Prototyping of Nanofluidic Slits in a Silicone Bilayer.
Kole TP, Liao KT, Schiffels D, Ilic BR, Strychalski EA, Kralj JG, Liddle JA, Dritschilo A, Stavis SM., J Res Natl Inst Stand Technol 120(), 2015
PMID: 26958449
Dielectrophoresis for bioparticle manipulation.
Qian C, Huang H, Chen L, Li X, Ge Z, Chen T, Yang Z, Sun L., Int J Mol Sci 15(10), 2014
PMID: 25310652
Dielectrophoresis based continuous-flow nano sorter: fast quality control of gene vaccines.
Viefhues M, Wegener S, Rischmuller A, Schleef M, Anselmetti D., Lab Chip 13(15), 2013
PMID: 23760065

47 References

Data provided by Europe PubMed Central.

Dielectrophoresis for the manipulation of nanobioparticles.
Lapizco-Encinas BH, Rito-Palomares M., Electrophoresis 28(24), 2007
PMID: 18072220

Probstein, 2003

Schoch, Rev. Mod. Phys. 80(), 2008
Conditions for similitude between the fluid velocity and electric field in electroosmotic flow
Cummings EB, Griffiths SK, Nilson RH, Paul PH., Anal. Chem. 72(11), 2000
PMID: 10857630

Pohl, 1978
The Dielectrophoretic Behavior of Submicron Latex Spheres: Influence of Surface Conductance.
Hughes MP, Morgan H, Flynn MF., J Colloid Interface Sci 220(2), 1999
PMID: 10607465
Measurement and interpretation of electrokinetic phenomena.
Delgado AV, Gonzalez-Caballero F, Hunter RJ, Koopal LK, Lyklema J; International Union of Pure and Applied Chemistry, Physical and Biophysical Chemistry Division IUPAC Technical Report., J Colloid Interface Sci 309(2), 2007
PMID: 17368660

Hänggi, Rev. Mod. Phys. 62(), 1990

Odom, Langmuir 18(), 2002
Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels.
Hellmich W, Regtmeier J, Duong TT, Ros R, Anselmetti D, Ros A., Langmuir 21(16), 2005
PMID: 16042494
Joule heating in electrokinetic flow.
Xuan X., Electrophoresis 29(1), 2008
PMID: 18058768
Joule heating effects on electroosmotic flow in insulator-based dielectrophoresis.
Sridharan S, Zhu J, Hu G, Xuan X., Electrophoresis 32(17), 2011
PMID: 21792988
Hard-wall interactions in soft matter systems: exact numerical treatment.
Behringer H, Eichhorn R., Phys Rev E Stat Nonlin Soft Matter Phys 83(6 Pt 2), 2011
PMID: 21797434

Deval, Proc 15th IEEE workshop on MEMS (), 2002

Lee, Proc 14th IEEE workshop on MEMS (), 2001
Hybrid electrokinetics for separation, mixing, and concentration of colloidal particles.
Sin ML, Shimabukuro Y, Wong PK., Nanotechnology 20(16), 2009
PMID: 19420574
Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles.
Tornay R, Braschler T, Demierre N, Steitz B, Finka A, Hofmann H, Hubbell JA, Renaud P., Lab Chip 8(2), 2008
PMID: 18231665
Dielectrophoretic manipulation of DNA: separation and polarizability.
Regtmeier J, Duong TT, Eichhorn R, Anselmetti D, Ros A., Anal. Chem. 79(10), 2007
PMID: 17444613
Dielectrophoretic trapping and polarizability of DNA: the role of spatial conformation.
Regtmeier J, Eichhorn R, Bogunovic L, Ros A, Anselmetti D., Anal. Chem. 82(17), 2010
PMID: 20690609
Trapping single molecules by dielectrophoresis.
Holzel R, Calander N, Chiragwandi Z, Willander M, Bier FF., Phys. Rev. Lett. 95(12), 2005
PMID: 16197115

Tay, Def. Sci. J. 59(), 2009

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 22193706
PubMed | Europe PMC

Search this title in

Google Scholar