Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri

Wansi J, Happi EN, Bavoua JLD, Devkota KP, Sewald N (2012)
Planta Medica 78(01): 71-75.

Journal Article | Published | English

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Abstract
Three new beta-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature information. The alkaloids 9-11 were isolated for the first time from this genus. All compounds were tested for their activity against bacteria, fungi, and plant pathogen oomycetes using the paper disk agar diffusion assay. The agar diffusion test gave only low antimicrobial activities, corresponding to MICs > 1 mg/mL. However, compounds 1-4 and 11 exhibited a strong suppressive effect on phagocytosis response upon activation with serum opsonized zymosan in the range of IC(50) = 2.6-6.5 mu M, while low cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3 was observed with IC(50) values ranging from 22.9 to 39.4 mu M.
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Wansi J, Happi EN, Bavoua JLD, Devkota KP, Sewald N. Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri. Planta Medica. 2012;78(01):71-75.
Wansi, J., Happi, E. N., Bavoua, J. L. D., Devkota, K. P., & Sewald, N. (2012). Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri. Planta Medica, 78(01), 71-75.
Wansi, J., Happi, E. N., Bavoua, J. L. D., Devkota, K. P., and Sewald, N. (2012). Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri. Planta Medica 78, 71-75.
Wansi, J., et al., 2012. Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri. Planta Medica, 78(01), p 71-75.
J. Wansi, et al., “Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri”, Planta Medica, vol. 78, 2012, pp. 71-75.
Wansi, J., Happi, E.N., Bavoua, J.L.D., Devkota, K.P., Sewald, N.: Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri. Planta Medica. 78, 71-75 (2012).
Wansi, Jean, Happi, Emmanuel Ngeufa, Bavoua, Judith Liliane Djouaka, Devkota, Krishna Prasad, and Sewald, Norbert. “Bioactive beta-indoloquinazoline Alkaloids from Oricia renieri”. Planta Medica 78.01 (2012): 71-75.
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PMID: 21928170
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