Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline

Berkessel A, Harnying W, Duangdee N, Neudoerfl J-M, Gröger H (2012)
Organic Process Research & Development 16(1): 123-128.

Journal Article | Published | English

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Abstract
A practical one-pot procedure for the preparation of Singh's catalyst from either L-/D-proline or Boc-proline is described. The coupling partner, a chiral amino alcohol, can be prepared and used directly without purification from the corresponding amino acid ester. Moreover, a procedure for tert-butoxycarbonyl (Boc) group removal using concentrated HCl in MeOH-DCM was developed and utilized for the multigram-scale synthesis of Singh's catalyst.
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Berkessel A, Harnying W, Duangdee N, Neudoerfl J-M, Gröger H. Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline. Organic Process Research & Development. 2012;16(1):123-128.
Berkessel, A., Harnying, W., Duangdee, N., Neudoerfl, J. - M., & Gröger, H. (2012). Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline. Organic Process Research & Development, 16(1), 123-128.
Berkessel, A., Harnying, W., Duangdee, N., Neudoerfl, J. - M., and Gröger, H. (2012). Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline. Organic Process Research & Development 16, 123-128.
Berkessel, A., et al., 2012. Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline. Organic Process Research & Development, 16(1), p 123-128.
A. Berkessel, et al., “Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline”, Organic Process Research & Development, vol. 16, 2012, pp. 123-128.
Berkessel, A., Harnying, W., Duangdee, N., Neudoerfl, J.-M., Gröger, H.: Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline. Organic Process Research & Development. 16, 123-128 (2012).
Berkessel, Albrecht, Harnying, Wacharee, Duangdee, Nongnaphat, Neudoerfl, Joerg-M., and Gröger, Harald. “Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline”. Organic Process Research & Development 16.1 (2012): 123-128.
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