Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure

Staudt S, Mueller CA, Marienhagen J, Boeing C, Buchholz S, Schwaneberg U, Gröger H (2012)
Beilstein Journal of Organic Chemistry 8: 186-191.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The hydroxylation of n-alkanes, which proceeds in the presence of a P450-monooxygenase advantageously at temperatures significantly below room temperature, is described. In addition, an enzymatic hydroxylation of the "liquid gas" n-butane with in situ cofactor regeneration, which does not require high-pressure conditions, was developed. The resulting 2-butanol was obtained as the only regioisomer, at a product concentration of 0.16 g/L.
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Zeitschriftentitel
Beilstein Journal of Organic Chemistry
Band
8
Seite
186-191
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Staudt S, Mueller CA, Marienhagen J, et al. Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure. Beilstein Journal of Organic Chemistry. 2012;8:186-191.
Staudt, S., Mueller, C. A., Marienhagen, J., Boeing, C., Buchholz, S., Schwaneberg, U., & Gröger, H. (2012). Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure. Beilstein Journal of Organic Chemistry, 8, 186-191. doi:10.3762/bjoc.8.20
Staudt, S., Mueller, C. A., Marienhagen, J., Boeing, C., Buchholz, S., Schwaneberg, U., and Gröger, H. (2012). Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure. Beilstein Journal of Organic Chemistry 8, 186-191.
Staudt, S., et al., 2012. Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure. Beilstein Journal of Organic Chemistry, 8, p 186-191.
S. Staudt, et al., “Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure”, Beilstein Journal of Organic Chemistry, vol. 8, 2012, pp. 186-191.
Staudt, S., Mueller, C.A., Marienhagen, J., Boeing, C., Buchholz, S., Schwaneberg, U., Gröger, H.: Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure. Beilstein Journal of Organic Chemistry. 8, 186-191 (2012).
Staudt, Svenja, Mueller, Christina A., Marienhagen, Jan, Boeing, Christian, Buchholz, Stefan, Schwaneberg, Ulrich, and Gröger, Harald. “Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure”. Beilstein Journal of Organic Chemistry 8 (2012): 186-191.

5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.
Venkataraman H, Verkade-Vreeker MC, Capoferri L, Geerke DP, Vermeulen NP, Commandeur JN., Bioorg Med Chem 22(20), 2014
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Direct oxidation of cycloalkanes to cycloalkanones with oxygen in water.
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Catalytic, mild, and selective oxyfunctionalization of linear alkanes: current challenges.
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PMID: 22996726

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