Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease

Redel P, Bublak P, Sorg C, Kurz A, Foerstl H, Mueller HJ, Schneider WX, Perneczky R, Finke K (2012)
Neurobiology of Aging 33(1): 195.e27-195.e42.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ; ; ;
Abstract / Bemerkung
Visual selective attention was assessed with a partial-report task in patients with probable Alzheimer's disease (AD), amnestic mild cognitive impairment (MCI), and healthy elderly controls. Based on Bundesen's "theory of visual attention" (TVA), two parameters were derived: top-down control of attentional selection, representing task-related attentional weighting for prioritizing relevant visual objects, and spatial distribution of attentional weights across the left and the right hemifield. Compared with controls, MCI patients showed significantly reduced top-down controlled selection, which was further deteriorated in AD subjects. Moreover, attentional weighting was significantly unbalanced across hemifields in MCI and tended to be more lateralized in AD. Across MCI and AD patients, carriers of the apolipoprotein E epsilon 4 allele (ApoE4) displayed a leftward spatial bias, which was the more pronounced the younger the ApoE4-positive patients and the earlier disease onset. These results indicate that impaired top-down control may be linked to early dysfunction of fronto-parietal networks. An early temporo-parietal interhemispheric asymmetry might cause a pathological spatial bias which is associated with ApoE4 genotype and may therefore function as early cognitive marker of upcoming AD. (C) 2012 Elsevier Inc. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
Neurobiology of Aging
Band
33
Ausgabe
1
Seite(n)
195.e27-195.e42
ISSN
PUB-ID

Zitieren

Redel P, Bublak P, Sorg C, et al. Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 2012;33(1):195.e27-195.e42.
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H. J., Schneider, W. X., et al. (2012). Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 33(1), 195.e27-195.e42. doi:10.1016/j.neurobiolaging.2010.05.014
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H. J., Schneider, W. X., Perneczky, R., and Finke, K. (2012). Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging 33, 195.e27-195.e42.
Redel, P., et al., 2012. Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 33(1), p 195.e27-195.e42.
P. Redel, et al., “Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease”, Neurobiology of Aging, vol. 33, 2012, pp. 195.e27-195.e42.
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H.J., Schneider, W.X., Perneczky, R., Finke, K.: Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 33, 195.e27-195.e42 (2012).
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H. J., Schneider, Werner X., Perneczky, R., and Finke, K. “Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease”. Neurobiology of Aging 33.1 (2012): 195.e27-195.e42.

10 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Distinctive Correspondence Between Separable Visual Attention Functions and Intrinsic Brain Networks.
Ruiz-Rizzo AL, Neitzel J, Müller HJ, Sorg C, Finke K., Front Hum Neurosci 12(), 2018
PMID: 29662444
Sensory dominance and multisensory integration as screening tools in aging.
Murray MM, Eardley AF, Edginton T, Oyekan R, Smyth E, Matusz PJ., Sci Rep 8(1), 2018
PMID: 29891964
Family History of Alzheimer's Disease is Associated with Impaired Perceptual Discrimination of Novel Objects.
Mason EJ, Hussey EP, Molitor RJ, Ko PC, Donahue MJ, Ally BA., J Alzheimers Dis 57(3), 2017
PMID: 28304286
Simultaneous object perception deficits are related to reduced visual processing speed in amnestic mild cognitive impairment.
Ruiz-Rizzo AL, Bublak P, Redel P, Grimmer T, Müller HJ, Sorg C, Finke K., Neurobiol Aging 55(), 2017
PMID: 28438484
Neuro-cognitive mechanisms of simultanagnosia in patients with posterior cortical atrophy.
Neitzel J, Ortner M, Haupt M, Redel P, Grimmer T, Yakushev I, Drzezga A, Bublak P, Preul C, Sorg C, Finke K., Brain 139(pt 12), 2016
PMID: 27702740
A Componential Analysis of Visual Attention in Children With ADHD.
McAvinue LP, Vangkilde S, Johnson KA, Habekost T, Kyllingsbæk S, Bundesen C, Robertson IH., J Atten Disord 19(10), 2015
PMID: 23190613
Preserved Suppression of Salient Irrelevant Stimuli During Visual Search in Age-Associated Memory Impairment.
Lorenzo-López L, Maseda A, Buján A, de Labra C, Amenedo E, Millán-Calenti JC., Front Psychol 6(), 2015
PMID: 26793148
Clinical TVA-based studies: a general review.
Habekost T., Front Psychol 6(), 2015
PMID: 25852607

78 References

Daten bereitgestellt von Europe PubMed Central.

Analysis of error types in the trial making test evidences an inhibitory deficit in dementia of the Alzheimer type.
Amieva H, Lafont S, Auriacombe S, Rainville C, Orgogozo JM, Dartigues JF, Fabrigoule C., J Clin Exp Neuropsychol 20(2), 1998
PMID: 9777482
Inhibitory functioning in Alzheimer's disease.
Amieva H, Phillips LH, Della Sala S, Henry JD., Brain 127(Pt 5), 2003
PMID: 14645147
Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study.
Ancelin ML, Artero S, Portet F, Dupuy AM, Touchon J, Ritchie K., BMJ 332(7539), 2006
PMID: 16452102
Patterns of interregional correlations of cerebral glucose metabolic rates in patients with dementia of the Alzheimer type
Azari, Neurodegeneration 1(), 1992
Attentional control in Alzheimer's disease.
Baddeley AD, Baddeley HA, Bucks RS, Wilcock GK., Brain 124(Pt 8), 2001
PMID: 11459742
Right-side neglect in Alzheimer's disease.
Bartolomeo P, Dalla Barba G, Boisse MF, Bachoud-Levi AC, Degos JD, Boller F., Neurology 51(4), 1998
PMID: 9781564
Alzheimer's disease.
Blennow K, de Leon MJ, Zetterberg H., Lancet 368(9533), 2006
PMID: 16876668
Neuropathological stageing of Alzheimer-related changes.
Braak H, Braak E., Acta Neuropathol. 82(4), 1991
PMID: 1759558
Staging of Alzheimer-related cortical destruction.
Braak H, Braak E, Bohl J., Eur. Neurol. 33(6), 1993
PMID: 8307060
Usability of a theory of visual attention (TVA) for parameter-based measurement of attention II: evidence from two patients with frontal or parietal damage.
Bublak P, Finke K, Krummenacher J, Preger R, Kyllingsbaek S, Muller HJ, Schneider WX., J Int Neuropsychol Soc 11(7), 2005
PMID: 16519263
Staged decline of visual processing capacity in mild cognitive impairment and Alzheimer's disease
Bublak, Neurobiol. Aging. (), 2009
A theory of visual attention
Bundesen, Psychol. Review 97(), 1990
A computational theory of visual attention.
Bundesen C., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 353(1373), 1998
PMID: 9770221
A total score for the CERAD neuropsychological battery.
Chandler MJ, Lacritz LH, Hynan LS, Barnard HD, Allen G, Deschner M, Weiner MF, Cullum CM., Neurology 65(1), 2005
PMID: 16009893
Frontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease.
Collette F, Van der Linden M, Delrue G, Salmon E., Alzheimer Dis Assoc Disord 16(4), 2002
PMID: 12468897
Alzheimer's disease as a disconnection syndrome?
Delbeuck, Neuropsychol. Review 13(), 2003
The neural substrates of memory systems impairment in Alzheimer's disease. A PET study of resting brain glucose utilization.
Desgranges B, Baron JC, de la Sayette V, Petit-Taboue MC, Benali K, Landeau B, Lechevalier B, Eustache F., Brain 121 ( Pt 4)(), 1998
PMID: 9577389
Neural mechanisms of selective visual attention
Desimone, Annu. Review Neurosci 18(), 1995
Distractibility and Alzheimer disease: the "neglected" phenomenon.
Drago V, Foster PS, Ferri R, Arico D, Lanuzza B, Heilman KM., J. Alzheimers Dis. 15(1), 2008
PMID: 18780963
Perceptual awareness and its loss in unilateral neglect and extinction.
Driver J, Vuilleumier P., Cognition 79(1-2), 2001
PMID: 11164023
Systematic analysis of deficits in visual attention
Duncan, J. Exp. Psych. Gen 128(), 1999
Parameter-based assessment of spatial and non-spatial attentional deficits in Huntington's disease.
Finke K, Bublak P, Dose M, Muller HJ, Schneider WX., Brain 129(Pt 5), 2006
PMID: 16504973
Usability of a theory of visual attention (TVA) for parameter-based measurement of attention I: evidence from normal subjects.
Finke K, Bublak P, Krummenacher J, Kyllingsbaek S, Muller HJ, Schneider WX., J Int Neuropsychol Soc 11(7), 2005
PMID: 16519262
The effect of attentional dysfunction in Alzheimer's disease: theoretical and practical implications.
Foldi NS, Lobosco JJ, Schaefer LA., Semin Speech Lang 23(2), 2002
PMID: 11951174
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.
Folstein MF, Folstein SE, McHugh PR., J Psychiatr Res 12(3), 1975
PMID: 1202204
Visual attention deficits in Alzheimer's disease: simple versus conjoined feature search.
Foster JK, Behrmann M, Stuss DT., Neuropsychology 13(2), 1999
PMID: 10353373
Mild cognitive impairment.
Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B; International Psychogeriatric Association Expert Conference on mild cognitive impairment., Lancet 367(9518), 2006
PMID: 16631882
Reaction times and performance variability in normal aging, mild cognitive impairment, and Alzheimer's disease.
Gorus E, De Raedt R, Lambert M, Lemper JC, Mets T., J Geriatr Psychiatry Neurol 21(3), 2008
PMID: 18838743
Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease.
Grady CL, Furey ML, Pietrini P, Horwitz B, Rapoport SI., Brain 124(Pt 4), 2001
PMID: 11287374
Visual attention deficits in Alzheimer's disease: an fMRI study.
Hao J, Li K, Li K, Zhang D, Wang W, Yang Y, Yan B, Shan B, Zhou X., Neurosci. Lett. 385(1), 2005
PMID: 15970381
The Bayer Activities of Daily Living Scale (B-ADL)
Hindmarch, Dement. Geriatr. Cognit. Disord. 9(suppl 2), 1998
Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease.
Horwitz B, Grady CL, Schlageter NL, Duara R, Rapoport SI., Brain Res. 407(2), 1987
PMID: 3494486
Unilateral spatial neglect in AD: significance of line bisection performance.
Ishiai S, Koyama Y, Seki K, Orimo S, Sodeyama N, Ozawa E, Lee EY, Takahashi M, Watabiki S, Okiyama R, Ohtake T, Hiroki M., Neurology 55(3), 2000
PMID: 10932269
Modeling visual attention.
Kyllingsbaek S., Behav Res Methods 38(1), 2006
PMID: 16817521
Hemispatial visual-searching impairment correlated with decreased contralateral parietal blood flow in Alzheimer disease
Meguro, Neuropsychiatr. Neuropsychol. Behav. Neurol 14(), 2001
Hemispatial neglect on visual search tasks in Alzheimer's disease
Mendez, Neuropsychiatr. Neuropsychol. Behav. Neurol 10(), 1997
Current concepts in Alzheimer's disease: a multidisciplinary review.
Minati L, Edginton T, Bruzzone MG, Giaccone G., Am J Alzheimers Dis Other Demen 24(2), 2009
PMID: 19116299
Outcome in subgroups of mild cognitive impairment (MCI) is highly predictable using a simple algorithm.
Mitchell J, Arnold R, Dawson K, Nestor PJ, Hodges JR., J. Neurol. 256(9), 2009
PMID: 19434441
Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve.
Mosconi L, Herholz K, Prohovnik I, Nacmias B, De Cristofaro MT, Fayyaz M, Bracco L, Sorbi S, Pupi A., J. Neurol. Neurosurg. Psychiatry 76(1), 2005
PMID: 15607989
Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease.
Mosconi L, Nacmias B, Sorbi S, De Cristofaro MT, Fayazz M, Tedde A, Bracco L, Herholz K, Pupi A., J. Neurol. Neurosurg. Psychiatry 75(3), 2004
PMID: 14966149
MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.
Mosconi L, Perani D, Sorbi S, Herholz K, Nacmias B, Holthoff V, Salmon E, Baron JC, De Cristofaro MT, Padovani A, Borroni B, Franceschi M, Bracco L, Pupi A., Neurology 63(12), 2004
PMID: 15623696
Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study.
Mosconi L, Sorbi S, Nacmias B, De Cristofaro MT, Fayyaz M, Bracco L, Herholz K, Pupi A., Psychiatry Res 130(2), 2004
PMID: 15033184
Advances in the early detection of Alzheimer's disease
Nestor, Nat. Med. 10(suppl), 2004
A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease.
O'Brien JT, Eagger S, Syed GM, Sahakian BJ, Levy R., J. Neurol. Neurosurg. Psychiatry 55(12), 1992
PMID: 1479398
The assessment and analysis of handedness: the Edinburgh inventory.
Oldfield RC., Neuropsychologia 9(1), 1971
PMID: 5146491
The apolipoprotein E gene, attention, and brain function.
Parasuraman R, Greenwood PM, Sunderland T., Neuropsychology 16(2), 2002
PMID: 11949718
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.
Pearson RC, Esiri MM, Hiorns RW, Wilcock GK, Powell TP., Proc. Natl. Acad. Sci. U.S.A. 82(13), 1985
PMID: 3859874
Attentional functions of parietal and frontal cortex.
Peers PV, Ludwig CJ, Rorden C, Cusack R, Bonfiglioli C, Bundesen C, Driver J, Antoun N, Duncan J., Cereb. Cortex 15(10), 2005
PMID: 15689522
Attention and executive deficits in Alzheimer's disease. A critical review.
Perry RJ, Hodges JR., Brain 122 ( Pt 3)(), 1999
PMID: 10094249
Mild cognitive impairment: clinical characterization and outcome.
Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E., Arch. Neurol. 56(3), 1999
PMID: 10190820
Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.
Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D., N. Engl. J. Med. 334(12), 1996
PMID: 8592548
Visual attention impairments in Alzheimer's disease.
Rizzo M, Anderson SW, Dawson J, Myers R, Ball K., Neurology 54(10), 2000
PMID: 10822436

Ross, 2000
Current approaches in the treatment of Alzheimer's disease.
Shah RS, Lee HG, Xiongwei Z, Perry G, Smith MA, Castellani RJ., Biomed. Pharmacother. 62(4), 2008
PMID: 18407457
The challenge of time: Clock-drawing and cognitive function in the elderly
Shulman, Int. J. Geriatr. Psychiatry 1(), 1986
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.
Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, Lavretsky H, Miller K, Siddarth P, Rasgon NL, Mazziotta JC, Saxena S, Wu HM, Mega MS, Cummings JL, Saunders AM, Pericak-Vance MA, Roses AD, Barrio JR, Phelps ME., Proc. Natl. Acad. Sci. U.S.A. 97(11), 2000
PMID: 10811879
Predictors of cognitive change in middle-aged and older adults with memory loss.
Small GW, La Rue A, Komo S, Kaplan A, Mandelkern MA., Am J Psychiatry 152(12), 1995
PMID: 8526242
Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease.
Small GW, Mazziotta JC, Collins MT, Baxter LR, Phelps ME, Mandelkern MA, Kaplan A, La Rue A, Adamson CF, Chang L., JAMA 273(12), 1995
PMID: 7884953
Selective changes of resting-state networks in individuals at risk for Alzheimer's disease.
Sorg C, Riedl V, Muhlau M, Calhoun VD, Eichele T, Laer L, Drzezga A, Forstl H, Kurz A, Zimmer C, Wohlschlager AM., Proc. Natl. Acad. Sci. U.S.A. 104(47), 2007
PMID: 18003904
Impact of Alzheimer's Disease on the Functional Connectivity of Spontaneous Brain Activity
Sorg, Curr. Alzheimer Res. 6, Nos 6(), 2009
Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment.
Tabert MH, Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, Zamora D, Goodkind M, Bell K, Stern Y, Devanand DP., Arch. Gen. Psychiatry 63(8), 2006
PMID: 16894068
Abnormal spatial and non-spatial cueing effects in mild cognitive impairment and Alzheimer's disease.
Tales A, Snowden RJ, Haworth J, Wilcock G., Neurocase 11(1), 2005
PMID: 15804929

Thalmann, 1997
Dynamics of gray matter loss in Alzheimer's disease.
Thompson PM, Hayashi KM, de Zubicaray G, Janke AL, Rose SE, Semple J, Herman D, Hong MS, Dittmer SS, Doddrell DM, Toga AW., J. Neurosci. 23(3), 2003
PMID: 12574429
CT study in senile dementia of Alzheimer type
Ueyama, Int. J. Geriatr. Psychiatry 9(), 1994
Unilateral spatial neglect in the late stage of Alzheimer's disease.
Venneri A, Pentore R, Cotticelli B, Della Sala S., Cortex 34(5), 1998
PMID: 9872376
Changes in brain functional homogeneity in subjects with Alzheimer's disease.
Volkow ND, Zhu W, Felder CA, Mueller K, Welsh TF, Wang GJ, de Leon MJ., Psychiatry Res 114(1), 2002
PMID: 11864808
3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease.
Whitwell JL, Przybelski SA, Weigand SD, Knopman DS, Boeve BF, Petersen RC, Jack CR Jr., Brain 130(Pt 7), 2007
PMID: 17533169

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 20561715
PubMed | Europe PMC

Suchen in

Google Scholar