Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease

Redel P, Bublak P, Sorg C, Kurz A, Foerstl H, Mueller HJ, Schneider WX, Perneczky R, Finke K (2012)
Neurobiology of Aging 33(1): 195.e27-195.e42.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Visual selective attention was assessed with a partial-report task in patients with probable Alzheimer's disease (AD), amnestic mild cognitive impairment (MCI), and healthy elderly controls. Based on Bundesen's "theory of visual attention" (TVA), two parameters were derived: top-down control of attentional selection, representing task-related attentional weighting for prioritizing relevant visual objects, and spatial distribution of attentional weights across the left and the right hemifield. Compared with controls, MCI patients showed significantly reduced top-down controlled selection, which was further deteriorated in AD subjects. Moreover, attentional weighting was significantly unbalanced across hemifields in MCI and tended to be more lateralized in AD. Across MCI and AD patients, carriers of the apolipoprotein E epsilon 4 allele (ApoE4) displayed a leftward spatial bias, which was the more pronounced the younger the ApoE4-positive patients and the earlier disease onset. These results indicate that impaired top-down control may be linked to early dysfunction of fronto-parietal networks. An early temporo-parietal interhemispheric asymmetry might cause a pathological spatial bias which is associated with ApoE4 genotype and may therefore function as early cognitive marker of upcoming AD. (C) 2012 Elsevier Inc. All rights reserved.
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Zeitschriftentitel
Neurobiology of Aging
Band
33
Zeitschriftennummer
1
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195.e27-195.e42
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Redel P, Bublak P, Sorg C, et al. Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 2012;33(1):195.e27-195.e42.
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H. J., Schneider, W. X., et al. (2012). Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 33(1), 195.e27-195.e42. doi:10.1016/j.neurobiolaging.2010.05.014
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H. J., Schneider, W. X., Perneczky, R., and Finke, K. (2012). Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging 33, 195.e27-195.e42.
Redel, P., et al., 2012. Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 33(1), p 195.e27-195.e42.
P. Redel, et al., “Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease”, Neurobiology of Aging, vol. 33, 2012, pp. 195.e27-195.e42.
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H.J., Schneider, W.X., Perneczky, R., Finke, K.: Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 33, 195.e27-195.e42 (2012).
Redel, P., Bublak, P., Sorg, C., Kurz, A., Foerstl, H., Mueller, H. J., Schneider, Werner X., Perneczky, R., and Finke, K. “Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease”. Neurobiology of Aging 33.1 (2012): 195.e27-195.e42.

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Simultaneous object perception deficits are related to reduced visual processing speed in amnestic mild cognitive impairment.
Ruiz-Rizzo AL, Bublak P, Redel P, Grimmer T, Müller HJ, Sorg C, Finke K., Neurobiol Aging 55(), 2017
PMID: 28438484
Neuro-cognitive mechanisms of simultanagnosia in patients with posterior cortical atrophy.
Neitzel J, Ortner M, Haupt M, Redel P, Grimmer T, Yakushev I, Drzezga A, Bublak P, Preul C, Sorg C, Finke K., Brain 139(pt 12), 2016
PMID: 27702740
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PMID: 23190613
Preserved Suppression of Salient Irrelevant Stimuli During Visual Search in Age-Associated Memory Impairment.
Lorenzo-López L, Maseda A, Buján A, de Labra C, Amenedo E, Millán-Calenti JC., Front Psychol 6(), 2015
PMID: 26793148
Clinical TVA-based studies: a general review.
Habekost T., Front Psychol 6(), 2015
PMID: 25852607

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