Brain synapses contain inducible forms of the transcription factor NF-kappa B

Kaltschmidt C, Kaltschmidt B, Baeuerle PA (1993)
Mech Dev 43(2-3): 135-47.

Journal Article | Published | English

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Abstract
We investigated the rat brain for the presence and activation state of the inducible transcription factor NF-kappa B. Two forms of NF-kappa B containing the transactivating p65 subunit were found in all brain regions investigated. The majority of NF-kappa B was in an inducible cytoplasmic form by virtue of its association with the inhibitory subunit I kappa B. Significant amounts of inducible NF-kappa B forms were present in synaptosomes, as suggested by electrophoretic mobility shift assay and Western blot analysis of subcellular brain fractions. A synaptic localization of NF-kappa B was further evident from immunostaining of inner and outer plexiform layers of the retina with an antibody directed against the p50 subunit of NF-kappa B. In cerebral cortex and striatum, NF-kappa B-specific antibodies showed a punctate immunostaining partially overlapping with that for the synaptic marker protein synaptophysin. NF-kappa B is thus the first transcription factor found in synapses of neurons. With its unusual subneuronal localization, the inducible transcription factor has the potential to function as retrograde messenger mediating stimulus-response coupling and long-term changes in gene expression following presynaptic stimulation.
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Kaltschmidt C, Kaltschmidt B, Baeuerle PA. Brain synapses contain inducible forms of the transcription factor NF-kappa B. Mech Dev. 1993;43(2-3):135-47.
Kaltschmidt, C., Kaltschmidt, B., & Baeuerle, P. A. (1993). Brain synapses contain inducible forms of the transcription factor NF-kappa B. Mech Dev, 43(2-3), 135-47.
Kaltschmidt, C., Kaltschmidt, B., and Baeuerle, P. A. (1993). Brain synapses contain inducible forms of the transcription factor NF-kappa B. Mech Dev 43, 135-47.
Kaltschmidt, C., Kaltschmidt, B., & Baeuerle, P.A., 1993. Brain synapses contain inducible forms of the transcription factor NF-kappa B. Mech Dev, 43(2-3), p 135-47.
C. Kaltschmidt, B. Kaltschmidt, and P.A. Baeuerle, “Brain synapses contain inducible forms of the transcription factor NF-kappa B”, Mech Dev, vol. 43, 1993, pp. 135-47.
Kaltschmidt, C., Kaltschmidt, B., Baeuerle, P.A.: Brain synapses contain inducible forms of the transcription factor NF-kappa B. Mech Dev. 43, 135-47 (1993).
Kaltschmidt, Christian, Kaltschmidt, Barbara, and Baeuerle, P. A. “Brain synapses contain inducible forms of the transcription factor NF-kappa B”. Mech Dev 43.2-3 (1993): 135-47.
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