Potential involvement of the transcription factor NF-kappa B in neurological disorders

Kaltschmidt B, Baeuerle PA, Kaltschmidt C (1993)
Mol Aspects Med 14(3): 171-190.

Journal Article | Published | English

No fulltext has been uploaded

Abstract
Reactive oxygen intermediates (ROIs) are involved in many neurological diseases. Despite the toxic nature of these compounds, low concentrations of ROIs can function as signaling molecules. One target for their signaling function is the inducible transcription factor NF-kappa B. Predominantly in lymphoid cells, induction of NF-kappa B in response to oxidative stress leads to transcriptional activation of many genes which are relevant for pathogen defense. These include the TNF, IL-6, IL-8, GM-CSF, beta-interferon, MHC class I and V-CAM genes. However, NF-kappa B is also abundant in various cell types of the nervous system, including neurons. We propose that NF-kappa B plays a role as a redox-controlled transcriptional activator also in cells of the nervous system and in that property may contribute to neurological disorders. Our finding that some neurons from healthy brain contain constitutively active NF-kappa B suggests a role of NF-kappa B in normal brain function as well.
Publishing Year
ISSN
PUB-ID

Cite this

Kaltschmidt B, Baeuerle PA, Kaltschmidt C. Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med. 1993;14(3):171-190.
Kaltschmidt, B., Baeuerle, P. A., & Kaltschmidt, C. (1993). Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med, 14(3), 171-190.
Kaltschmidt, B., Baeuerle, P. A., and Kaltschmidt, C. (1993). Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med 14, 171-190.
Kaltschmidt, B., Baeuerle, P.A., & Kaltschmidt, C., 1993. Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med, 14(3), p 171-190.
B. Kaltschmidt, P.A. Baeuerle, and C. Kaltschmidt, “Potential involvement of the transcription factor NF-kappa B in neurological disorders”, Mol Aspects Med, vol. 14, 1993, pp. 171-190.
Kaltschmidt, B., Baeuerle, P.A., Kaltschmidt, C.: Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med. 14, 171-190 (1993).
Kaltschmidt, Barbara, Baeuerle, P. A., and Kaltschmidt, Christian. “Potential involvement of the transcription factor NF-kappa B in neurological disorders”. Mol Aspects Med 14.3 (1993): 171-190.
This data publication is cited in the following publications:
This publication cites the following data publications:

55 Citations in Europe PMC

Data provided by Europe PubMed Central.

Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis.
Zhao H, Xu J, Pang L, Zhang Y, Fan H, Liu L, Liu T, Yu F, Zhang G, Lan Y, Bai J, Li X, Xiao Y., BMC Med Genomics 8(), 2015
PMID: 26462620
Impact of nuclear factor-κB on restoration of neuron growth and differentiation in hippocampus of degenerative brain.
Aloor R, Zhang C, Bandyopadhyay M, Dasgupta S., J. Neurosci. Res. 93(10), 2015
PMID: 25586448
Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats.
Kahveci R, Gokce EC, Gurer B, Gokce A, Kisa U, Cemil DB, Sargon MF, Kahveci FO, Aksoy N, Erdogan B., Eur. J. Pharmacol. 741(), 2014
PMID: 25084223

78 References

Data provided by Europe PubMed Central.

Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review).
Schreck R, Albermann K, Baeuerle PA., Free Radic. Res. Commun. 17(4), 1992
PMID: 1473734
Chapter 4 Traumatic and Ischemia/Reperfusion Injury to the CNS
MCCALL, 1992
Effects of dietary linoleic acid and gamma linolenic acid on platelets of patients with multiple sclerosis.
Mcgregor L, Smith AD, Sidey M, Belin J, Zilkha KJ, McGregor JL., Acta Neurol. Scand. 80(1), 1989
PMID: 2782038

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 8264332
PubMed | Europe PMC

Search this title in

Google Scholar