miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling

Lüningschrör P, Stoecker B, Kaltschmidt B, Kaltschmidt C (2012)
Stem Cells 30(4): 655-664.

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Abstract
Embryonic stem cell (ESC)-specific microRNAs (miRNAs) play a critical role in the maintenance of pluripotency and self-renewal but the complete network between these miRNAs and their broad range of target genes still remains elusive. Here we demonstrate that miR-290 cluster, the most abundant miRNA family in ESCs, targets the NF-?B subunit p65 (also known as RelA) by repressing its translation. Forced expression of p65 causes loss of pluripotency, promotes differentiation of ESCs, and leads to an epithelial to mesenchymal transition. These data define p65 as a novel target gene of miR-290 cluster and provide new insight into the function of ESC-specific miRNAs. STEM CELLS 2012; 30:655664
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Lüningschrör P, Stoecker B, Kaltschmidt B, Kaltschmidt C. miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells. 2012;30(4):655-664.
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., & Kaltschmidt, C. (2012). miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells, 30(4), 655-664. doi:10.1002/stem.1033
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., and Kaltschmidt, C. (2012). miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells 30, 655-664.
Lüningschrör, P., et al., 2012. miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells, 30(4), p 655-664.
P. Lüningschrör, et al., “miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling”, Stem Cells, vol. 30, 2012, pp. 655-664.
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., Kaltschmidt, C.: miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells. 30, 655-664 (2012).
Lüningschrör, Patrick, Stoecker, B., Kaltschmidt, Barbara, and Kaltschmidt, Christian. “miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling”. Stem Cells 30.4 (2012): 655-664.
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26 Citations in Europe PMC

Data provided by Europe PubMed Central.

miRNAs involved in the generation, maintenance, and differentiation of pluripotent cells.
Pfaff N, Moritz T, Thum T, Cantz T., J Mol Med (Berl) 90(7), 2012
PMID: 22684238

36 References

Data provided by Europe PubMed Central.

A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.
Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA, Pei D., Cell Stem Cell 7(1), 2010
PMID: 20621050
Epithelial-mesenchymal transitions in development and disease.
Thiery JP, Acloque H, Huang RY, Nieto MA., Cell 139(5), 2009
PMID: 19945376
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression.
Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T., J. Clin. Invest. 114(4), 2004
PMID: 15314694
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells.
Niwa H, Ogawa K, Shimosato D, Adachi K., Nature 460(7251), 2009
PMID: 19571885

AUTHOR UNKNOWN, 0
Chromatin connections to pluripotency and cellular reprogramming.
Orkin SH, Hochedlinger K., Cell 145(6), 2011
PMID: 21663790
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.
Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R., Nat. Biotechnol. 29(5), 2011
PMID: 21490602
Reprogramming of mouse and human cells to pluripotency using mature microRNAs.
Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL, Kano Y, Nishikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M., Cell Stem Cell 8(6), 2011
PMID: 21620789
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