A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development

Baer K, Dückers N, Rosenbaum T, Leggewie C, Simon S, Krausser M, Osswald S, Hummel W, Gröger H (2011)
Tetrahedron Asymmetry 22(9): 925-928.

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Abstract
The development of aldol reactions of glycine with substituted benzaldehydes in the presence of recombinant L-threonine aldolases from Escherichia coil or Saccharomyces cerevisiae, which were obtained with excellent overexpression data, has been carried out. When using glycine and ortho-chlorobenzaldehyde, a high conversion of >95%, an enantioselectivity of >99% ee, and a diastereoselectivity with d.r.(syn/anti) = 80:20 was obtained for the resulting beta-hydroxy alpha-amino acid in such a biotransformation. It should be noted that this enzymatic process can be conducted at an elevated substrate concentration of 250 mM. (C) 2011 Elsevier Ltd. All rights reserved.
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Baer K, Dückers N, Rosenbaum T, et al. A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development. Tetrahedron Asymmetry. 2011;22(9):925-928.
Baer, K., Dückers, N., Rosenbaum, T., Leggewie, C., Simon, S., Krausser, M., Osswald, S., et al. (2011). A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development. Tetrahedron Asymmetry, 22(9), 925-928.
Baer, K., Dückers, N., Rosenbaum, T., Leggewie, C., Simon, S., Krausser, M., Osswald, S., Hummel, W., and Gröger, H. (2011). A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development. Tetrahedron Asymmetry 22, 925-928.
Baer, K., et al., 2011. A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development. Tetrahedron Asymmetry, 22(9), p 925-928.
K. Baer, et al., “A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development”, Tetrahedron Asymmetry, vol. 22, 2011, pp. 925-928.
Baer, K., Dückers, N., Rosenbaum, T., Leggewie, C., Simon, S., Krausser, M., Osswald, S., Hummel, W., Gröger, H.: A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development. Tetrahedron Asymmetry. 22, 925-928 (2011).
Baer, Katrin, Dückers, Nina, Rosenbaum, Thorsten, Leggewie, Christian, Simon, Sabine, Krausser, Marina, Osswald, Steffen, Hummel, Werner, and Gröger, Harald. “A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development”. Tetrahedron Asymmetry 22.9 (2011): 925-928.
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