Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis

Hinse D, Vollmer T, Rückert C, Blom J, Kalinowski J, Knabbe C, Dreier J (2011)
BMC Genomics 12(1): 400.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Background: Streptococcus gallolyticus subsp. gallolyticus is an important causative agent of infectious endocarditis, while the pathogenicity of this species is widely unclear. To gain insight into the pathomechanisms and the underlying genetic elements for lateral gene transfer, we sequenced the entire genome of this pathogen. Results: We sequenced the whole genome of S. gallolyticus subsp. gallolyticus strain ATCC BAA-2069, consisting of a 2,356,444 bp circular DNA molecule with a G+C-content of 37.65% and a novel 20,765 bp plasmid designated as pSGG1. Bioinformatic analysis predicted 2,309 ORFs and the presence of 80 tRNAs and 21 rRNAs in the chromosome. Furthermore, 21 ORFs were detected on the plasmid pSGG1, including tetracycline resistance genes telL and tet(O/W/32/O). Screening of 41 S. gallolyticus subsp. gallolyticus isolates revealed one plasmid (pSGG2) homologous to pSGG1. We further predicted 21 surface proteins containing the cell wall-sorting motif LPxTG, which were shown to play a functional role in the adhesion of bacteria to host cells. In addition, we performed a whole genome comparison to the recently sequenced S. gallolyticus subsp. gallolyticus strain UCN34, revealing significant differences. Conclusions: The analysis of the whole genome sequence of S. gallolyticus subsp. gallolyticus promotes understanding of genetic factors concerning the pathogenesis and adhesion to ECM of this pathogen. For the first time we detected the presence of the mobilizable pSGG1 plasmid, which may play a functional role in lateral gene transfer and promote a selective advantage due to a tetracycline resistance.
Erscheinungsjahr
Zeitschriftentitel
BMC Genomics
Band
12
Zeitschriftennummer
1
Seite
400
ISSN
PUB-ID

Zitieren

Hinse D, Vollmer T, Rückert C, et al. Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics. 2011;12(1):400.
Hinse, D., Vollmer, T., Rückert, C., Blom, J., Kalinowski, J., Knabbe, C., & Dreier, J. (2011). Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics, 12(1), 400. doi:10.1186/1471-2164-12-400
Hinse, D., Vollmer, T., Rückert, C., Blom, J., Kalinowski, J., Knabbe, C., and Dreier, J. (2011). Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics 12, 400.
Hinse, D., et al., 2011. Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics, 12(1), p 400.
D. Hinse, et al., “Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis”, BMC Genomics, vol. 12, 2011, pp. 400.
Hinse, D., Vollmer, T., Rückert, C., Blom, J., Kalinowski, J., Knabbe, C., Dreier, J.: Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics. 12, 400 (2011).
Hinse, Dennis, Vollmer, Tanja, Rückert, Christian, Blom, Jochen, Kalinowski, Jörn, Knabbe, Cornelius, and Dreier, Jens. “Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis”. BMC Genomics 12.1 (2011): 400.

20 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.
Butt J, Jenab M, Willhauck-Fleckenstein M, Michel A, Pawlita M, Kyrø C, Tjønneland A, Boutron-Ruault MC, Carbonnel F, Severi G, Kaaks R, Kühn T, Boeing H, Trichopoulou A, la Vecchia C, Karakatsani A, Panico S, Tumino R, Agnoli C, Palli D, Sacerdote C, Bueno-de-Mesquita B, Weiderpass E, Sánchez MJ, Bonet Bonet C, Huerta JM, Ardanaz E, Bradbury K, Gunter M, Murphy N, Freisling H, Riboli E, Tsilidis K, Aune D, Waterboer T, Hughes DJ., Int J Cancer (), 2018
PMID: 29377173
Serology of Streptococcus gallolyticus subspecies gallolyticus and its association with colorectal cancer and precursors.
Butt J, Werner S, Willhauck-Fleckenstein M, Michel A, Waterboer T, Zörnig I, Boleij A, Dramsi S, Brenner H, Pawlita M., Int J Cancer 141(5), 2017
PMID: 28477334
Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.
Kumar R, Herold JL, Schady D, Davis J, Kopetz S, Martinez-Moczygemba M, Murray BE, Han F, Li Y, Callaway E, Chapkin RS, Dashwood WM, Dashwood RH, Berry T, Mackenzie C, Xu Y., PLoS Pathog 13(7), 2017
PMID: 28704539
Mosaic tetracycline resistance genes encoding ribosomal protection proteins.
Warburton PJ, Amodeo N, Roberts AP., J Antimicrob Chemother 71(12), 2016
PMID: 27494928
Streptococcus gallolyticus subsp. gallolyticus from human and animal origins: genetic diversity, antimicrobial susceptibility, and characterization of a vancomycin-resistant calf isolate carrying a vanA-Tn1546-like element.
Romero-Hernández B, Tedim AP, Sánchez-Herrero JF, Librado P, Rozas J, Muñoz G, Baquero F, Cantón R, Del Campo R., Antimicrob Agents Chemother 59(4), 2015
PMID: 25605355
Comparative metagenomics of biogas-producing microbial communities from production-scale biogas plants operating under wet or dry fermentation conditions.
Stolze Y, Zakrzewski M, Maus I, Eikmeyer F, Jaenicke S, Rottmann N, Siebner C, Pühler A, Schlüter A., Biotechnol Biofuels 8(), 2015
PMID: 25688290
Viridans and bovis group streptococci that cause infective endocarditis in two regions with contrasting epidemiology.
Naveen Kumar V, van der Linden M, Menon T, Nitsche-Schmitz DP., Int J Med Microbiol 304(3-4), 2014
PMID: 24220665
Molecular identification key of the family Streptococcaceae.
Kanyó I, Nagy D., Acta Microbiol Immunol Hung 61(1), 2014
PMID: 24631752
Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex.
Papadimitriou K, Anastasiou R, Mavrogonatou E, Blom J, Papandreou NC, Hamodrakas SJ, Ferreira S, Renault P, Supply P, Pot B, Tsakalidou E., BMC Genomics 15(), 2014
PMID: 24713045
Development and application of a multilocus sequence typing scheme for Streptococcus gallolyticus subsp. gallolyticus.
Dumke J, Hinse D, Vollmer T, Knabbe C, Dreier J., J Clin Microbiol 52(7), 2014
PMID: 24789199
Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens.
Palmieri C, Magi G, Mingoia M, Bagnarelli P, Ripa S, Varaldo PE, Facinelli B., Antimicrob Agents Chemother 56(9), 2012
PMID: 22710115
Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.
Søndergaard A, San Millan A, Santos-Lopez A, Nielsen SM, Gonzalez-Zorn B, Nørskov-Lauritsen N., Antimicrob Agents Chemother 56(9), 2012
PMID: 22733069

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 21824414
PubMed | Europe PMC

Suchen in

Google Scholar