Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis

Hinse D, Vollmer T, Rückert C, Blom J, Kalinowski J, Knabbe C, Dreier J (2011)
BMC Genomics 12(1): 400.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Background: Streptococcus gallolyticus subsp. gallolyticus is an important causative agent of infectious endocarditis, while the pathogenicity of this species is widely unclear. To gain insight into the pathomechanisms and the underlying genetic elements for lateral gene transfer, we sequenced the entire genome of this pathogen. Results: We sequenced the whole genome of S. gallolyticus subsp. gallolyticus strain ATCC BAA-2069, consisting of a 2,356,444 bp circular DNA molecule with a G+C-content of 37.65% and a novel 20,765 bp plasmid designated as pSGG1. Bioinformatic analysis predicted 2,309 ORFs and the presence of 80 tRNAs and 21 rRNAs in the chromosome. Furthermore, 21 ORFs were detected on the plasmid pSGG1, including tetracycline resistance genes telL and tet(O/W/32/O). Screening of 41 S. gallolyticus subsp. gallolyticus isolates revealed one plasmid (pSGG2) homologous to pSGG1. We further predicted 21 surface proteins containing the cell wall-sorting motif LPxTG, which were shown to play a functional role in the adhesion of bacteria to host cells. In addition, we performed a whole genome comparison to the recently sequenced S. gallolyticus subsp. gallolyticus strain UCN34, revealing significant differences. Conclusions: The analysis of the whole genome sequence of S. gallolyticus subsp. gallolyticus promotes understanding of genetic factors concerning the pathogenesis and adhesion to ECM of this pathogen. For the first time we detected the presence of the mobilizable pSGG1 plasmid, which may play a functional role in lateral gene transfer and promote a selective advantage due to a tetracycline resistance.
Erscheinungsjahr
Zeitschriftentitel
BMC Genomics
Band
12
Zeitschriftennummer
1
Seite
400
ISSN
PUB-ID

Zitieren

Hinse D, Vollmer T, Rückert C, et al. Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics. 2011;12(1):400.
Hinse, D., Vollmer, T., Rückert, C., Blom, J., Kalinowski, J., Knabbe, C., & Dreier, J. (2011). Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics, 12(1), 400. doi:10.1186/1471-2164-12-400
Hinse, D., Vollmer, T., Rückert, C., Blom, J., Kalinowski, J., Knabbe, C., and Dreier, J. (2011). Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics 12, 400.
Hinse, D., et al., 2011. Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics, 12(1), p 400.
D. Hinse, et al., “Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis”, BMC Genomics, vol. 12, 2011, pp. 400.
Hinse, D., Vollmer, T., Rückert, C., Blom, J., Kalinowski, J., Knabbe, C., Dreier, J.: Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis. BMC Genomics. 12, 400 (2011).
Hinse, Dennis, Vollmer, Tanja, Rückert, Christian, Blom, Jochen, Kalinowski, Jörn, Knabbe, Cornelius, and Dreier, Jens. “Complete genome and comparative analysis of Streptococcus gallolyticus subsp gallolyticus, an emerging pathogen of infective endocarditis”. BMC Genomics 12.1 (2011): 400.

25 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.
Butt J, Jenab M, Willhauck-Fleckenstein M, Michel A, Pawlita M, Kyrø C, Tjønneland A, Boutron-Ruault MC, Carbonnel F, Severi G, Kaaks R, Kühn T, Boeing H, Trichopoulou A, la Vecchia C, Karakatsani A, Panico S, Tumino R, Agnoli C, Palli D, Sacerdote C, Bueno-de-Mesquita HBA, Weiderpass E, Sánchez MJ, Bonet Bonet C, Huerta JM, Ardanaz E, Bradbury K, Gunter M, Murphy N, Freisling H, Riboli E, Tsilidis K, Aune D, Waterboer T, Hughes DJ., Int J Cancer 143(2), 2018
PMID: 29377173
Complete Genome Sequence of the Streptococcus gallolyticus subsp. gallolyticus Strain DSM 16831.
Grimm I, Dumke J, Vollmer T, Hinse D, Rückert C, Kalinowski J, Knabbe C, Dreier J., Genome Announc 5(16), 2017
PMID: 28428288
Serology of Streptococcus gallolyticus subspecies gallolyticus and its association with colorectal cancer and precursors.
Butt J, Werner S, Willhauck-Fleckenstein M, Michel A, Waterboer T, Zörnig I, Boleij A, Dramsi S, Brenner H, Pawlita M., Int J Cancer 141(5), 2017
PMID: 28477334
Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.
Kumar R, Herold JL, Schady D, Davis J, Kopetz S, Martinez-Moczygemba M, Murray BE, Han F, Li Y, Callaway E, Chapkin RS, Dashwood WM, Dashwood RH, Berry T, Mackenzie C, Xu Y., PLoS Pathog 13(7), 2017
PMID: 28704539
Mosaic tetracycline resistance genes encoding ribosomal protection proteins.
Warburton PJ, Amodeo N, Roberts AP., J Antimicrob Chemother 71(12), 2016
PMID: 27494928
Streptococcus gallolyticus subsp. gallolyticus from human and animal origins: genetic diversity, antimicrobial susceptibility, and characterization of a vancomycin-resistant calf isolate carrying a vanA-Tn1546-like element.
Romero-Hernández B, Tedim AP, Sánchez-Herrero JF, Librado P, Rozas J, Muñoz G, Baquero F, Cantón R, Del Campo R., Antimicrob Agents Chemother 59(4), 2015
PMID: 25605355
Comparative metagenomics of biogas-producing microbial communities from production-scale biogas plants operating under wet or dry fermentation conditions.
Stolze Y, Zakrzewski M, Maus I, Eikmeyer F, Jaenicke S, Rottmann N, Siebner C, Pühler A, Schlüter A., Biotechnol Biofuels 8(), 2015
PMID: 25688290
Viridans and bovis group streptococci that cause infective endocarditis in two regions with contrasting epidemiology.
Naveen Kumar V, van der Linden M, Menon T, Nitsche-Schmitz DP., Int J Med Microbiol 304(3-4), 2014
PMID: 24220665
Molecular identification key of the family Streptococcaceae.
Kanyó I, Nagy D., Acta Microbiol Immunol Hung 61(1), 2014
PMID: 24631752
Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex.
Papadimitriou K, Anastasiou R, Mavrogonatou E, Blom J, Papandreou NC, Hamodrakas SJ, Ferreira S, Renault P, Supply P, Pot B, Tsakalidou E., BMC Genomics 15(), 2014
PMID: 24713045
Development and application of a multilocus sequence typing scheme for Streptococcus gallolyticus subsp. gallolyticus.
Dumke J, Hinse D, Vollmer T, Knabbe C, Dreier J., J Clin Microbiol 52(7), 2014
PMID: 24789199
Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens.
Palmieri C, Magi G, Mingoia M, Bagnarelli P, Ripa S, Varaldo PE, Facinelli B., Antimicrob Agents Chemother 56(9), 2012
PMID: 22710115
Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.
Søndergaard A, San Millan A, Santos-Lopez A, Nielsen SM, Gonzalez-Zorn B, Nørskov-Lauritsen N., Antimicrob Agents Chemother 56(9), 2012
PMID: 22733069

62 References

Daten bereitgestellt von Europe PubMed Central.

Taxonomic studies on Streptococcus bovis and Streptococcus equinus: description of Streptococcus alactolyticus sp. nov. and Streptococcus saccharolyticus sp. nov
AUTHOR UNKNOWN, 1984
Streptococcus gallolyticus sp. nov.; gallate degrading organisms formerly assigned to Streptococcus bovis
AUTHOR UNKNOWN, 1995
Association of Streptococcus bovis with carcinoma of the colon.
Klein RS, Recco RA, Catalano MT, Edberg SC, Casey JI, Steigbigel NH., N. Engl. J. Med. 297(15), 1977
PMID: 408687
Molecular epidemiology of Streptococcus bovis causing endocarditis and bacteraemia in Italian patients.
Tripodi MF, Fortunato R, Utili R, Triassi M, Zarrilli R., Clin. Microbiol. Infect. 11(10), 2005
PMID: 16153255
Emergence of endocarditis due to group D streptococci: findings derived from the merged database of the International Collaboration on Endocarditis.
Hoen B, Chirouze C, Cabell CH, Selton-Suty C, Duchene F, Olaison L, Miro JM, Habib G, Abrutyn E, Eykyn S, Bernard Y, Marco F, Corey GR; International Collaboration on Endocarditis Study Group., Eur. J. Clin. Microbiol. Infect. Dis. 24(1), 2005
PMID: 15660254
23S rDNA real-time polymerase chain reaction of heart valves: a decisive tool in the diagnosis of infective endocarditis.
Vollmer T, Piper C, Horstkotte D, Korfer R, Kleesiek K, Dreier J., Eur. Heart J. 31(9), 2010
PMID: 20093256
[Streptococcus bovis endocarditis - predictor of colonic carcinoma? ].
Arzanauskiene R, Zabiela P, Sakalnikiene M., Medicina (Kaunas) 39(2), 2003
PMID: 12626871
A collagen-binding adhesin, Acb, and ten other putative MSCRAMM and pilus family proteins of Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis Group, biotype I).
Sillanpaa J, Nallapareddy SR, Qin X, Singh KV, Muzny DM, Kovar CL, Nazareth LV, Gibbs RA, Ferraro MJ, Steckelberg JM, Weinstock GM, Murray BE., J. Bacteriol. 191(21), 2009
PMID: 19717590
Profiling the humoral immune response in colon cancer patients: diagnostic antigens from Streptococcus bovis.
Tjalsma H, Scholler-Guinard M, Lasonder E, Ruers TJ, Willems HL, Swinkels DW., Int. J. Cancer 119(9), 2006
PMID: 16841330
ARDRA and RAPD analyses of human and animal isolates of Streptococcus gallolyticus.
Sasaki E, Osawa R, Nishitani Y, Whiley RA., J. Vet. Med. Sci. 66(11), 2004
PMID: 15585969
Genomic fingerprinting of pigeon Streptococcus gallolyticus strains of different virulence by randomly amplified polymorphic DNA (RAPD) analysis.
Baele M, Vanrobaeys M, Vaneechoutte M, De Herdt P, Devriese LA, Haesebrouck F., Vet. Microbiol. 71(1-2), 2000
PMID: 10665538
Gene transfer events and their occurrence in selected environments.
Kelly BG, Vespermann A, Bolton DJ., Food Chem. Toxicol. 47(5), 2008
PMID: 18639605
Positive selection in the ComC-ComD system of Streptococcal Species.
Ichihara H, Kuma K, Toh H., J. Bacteriol. 188(17), 2006
PMID: 16923913
Genetic exchange between bacteria in the environment.
Davison J., Plasmid 42(2), 1999
PMID: 10489325
Natural genetic transformation of Streptococcus mutans growing in biofilms.
Li YH, Lau PC, Lee JH, Ellen RP, Cvitkovitch DG., J. Bacteriol. 183(3), 2001
PMID: 11208787
Conjugative transfer of the integrative conjugative elements ICESt1 and ICESt3 from Streptococcus thermophilus.
Bellanger X, Roberts AP, Morel C, Choulet F, Pavlovic G, Mullany P, Decaris B, Guedon G., J. Bacteriol. 191(8), 2009
PMID: 19181800
Adhesion of Streptococcus gallolyticus strains to extracellular matrix proteins.
Vanrobaeys M, Haesebrouck F, Ducatelle R, De Herdt P., Vet. Microbiol. 74(3), 2000
PMID: 10808095
Surface-exposed histone-like protein a modulates adherence of Streptococcus gallolyticus to colon adenocarcinoma cells.
Boleij A, Schaeps RM, de Kleijn S, Hermans PW, Glaser P, Pancholi V, Swinkels DW, Tjalsma H., Infect. Immun. 77(12), 2009
PMID: 19752027
Secreted antigens as virulence associated markers in Streptococcus bovis strains from pigeons.
Vanrobaeys M, De Herdt P, Haesebrouck F, Ducatelle R, Devriese LA., Vet. Microbiol. 53(3-4), 1996
PMID: 9008344
Biochemical and antigenic properties of Streptococcus bovis isolated from pigeons.
De Herdt P, Haesebrouck F, Devriese LA, Ducatelle R., J. Clin. Microbiol. 30(9), 1992
PMID: 1401011
Ultrastructure of surface components of Streptococcus gallolytics (S. bovis) strains of differing virulence isolated from pigeons.
Vanrobaeys M, De Herdt P, Charlier G, Ducatelle R, Haesebrouck F., Microbiology (Reading, Engl.) 145 ( Pt 2)(), 1999
PMID: 10075416
Genome sequence of Streptococcus gallolyticus: insights into its adaptation to the bovine rumen and its ability to cause endocarditis.
Rusniok C, Couve E, Da Cunha V, El Gana R, Zidane N, Bouchier C, Poyart C, Leclercq R, Trieu-Cuot P, Glaser P., J. Bacteriol. 192(8), 2010
PMID: 20139183
Mauve: multiple alignment of conserved genomic sequence with rearrangements.
Darling AC, Mau B, Blattner FR, Perna NT., Genome Res. 14(7), 2004
PMID: 15231754
Streptococcus rattus strain BHT produces both a class I two-component lantibiotic and a class II bacteriocin.
Hyink O, Balakrishnan M, Tagg JR., FEMS Microbiol. Lett. 252(2), 2005
PMID: 16194596
Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.
Paulsen IT, Banerjei L, Myers GS, Nelson KE, Seshadri R, Read TD, Fouts DE, Eisen JA, Gill SR, Heidelberg JF, Tettelin H, Dodson RJ, Umayam L, Brinkac L, Beanan M, Daugherty S, DeBoy RT, Durkin S, Kolonay J, Madupu R, Nelson W, Vamathevan J, Tran B, Upton J, Hansen T, Shetty J, Khouri H, Utterback T, Radune D, Ketchum KA, Dougherty BA, Fraser CM., Science 299(5615), 2003
PMID: 12663927
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF.
Bourgogne A, Garsin DA, Qin X, Singh KV, Sillanpaa J, Yerrapragada S, Ding Y, Dugan-Rocha S, Buhay C, Shen H, Chen G, Williams G, Muzny D, Maadani A, Fox KA, Gioia J, Chen L, Shang Y, Arias CA, Nallapareddy SR, Zhao M, Prakash VP, Chowdhury S, Jiang H, Gibbs RA, Murray BE, Highlander SK, Weinstock GM., Genome Biol. 9(7), 2008
PMID: 18611278
Complete genome sequence of the commensal Enterococcus faecalis 62, isolated from a healthy Norwegian infant.
Brede DA, Snipen LG, Ussery DW, Nederbragt AJ, Nes IF., J. Bacteriol. 193(9), 2011
PMID: 21398545
EDGAR: a software framework for the comparative analysis of prokaryotic genomes.
Blom J, Albaum SP, Doppmeier D, Puhler A, Vorholter FJ, Zakrzewski M, Goesmann A., BMC Bioinformatics 10(), 2009
PMID: 19457249
The diversity of conjugative relaxases and its application in plasmid classification.
Garcillan-Barcia MP, Francia MV, de la Cruz F., FEMS Microbiol. Rev. 33(3), 2009
PMID: 19396961
Characterization of the cryptic plasmid pSBO2 isolated from Streptococcus bovis JB1 and construction of a new shuttle vector.
Nakamura M, Ogata K, Nagamine T, Tajima K, Matsui H, Benno Y., Curr. Microbiol. 41(1), 2000
PMID: 10919395
Virulence-associated gene profiling of Streptococcus suis isolates by PCR.
Silva LM, Baums CG, Rehm T, Wisselink HJ, Goethe R, Valentin-Weigand P., Vet. Microbiol. 115(1-3), 2006
PMID: 16431041
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarit y Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O'Connor KJ, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madoff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM., Proc. Natl. Acad. Sci. U.S.A. 102(39), 2005
PMID: 16172379
Multiple-locus variable-number tandem repeat analysis reveals genetic relationships within Bacillus anthracis.
Keim P, Price LB, Klevytska AM, Smith KL, Schupp JM, Okinaka R, Jackson PJ, Hugh-Jones ME., J. Bacteriol. 182(10), 2000
PMID: 10781564
The association of virulence factors with genomic islands.
Ho Sui SJ, Fedynak A, Hsiao WW, Langille MG, Brinkman FS., PLoS ONE 4(12), 2009
PMID: 19956607
CRISPR/Cas, the immune system of bacteria and archaea.
Horvath P, Barrangou R., Science 327(5962), 2010
PMID: 20056882
Genome-wide detection and analysis of cell wall-bound proteins with LPxTG-like sorting motifs.
Boekhorst J, de Been MW, Kleerebezem M, Siezen RJ., J. Bacteriol. 187(14), 2005
PMID: 15995208
Mosaic tetracycline resistance genes are widespread in human and animal fecal samples.
Patterson AJ, Rincon MT, Flint HJ, Scott KP., Antimicrob. Agents Chemother. 51(3), 2006
PMID: 17178791
Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance.
Speer BS, Shoemaker NB, Salyers AA., Clin. Microbiol. Rev. 5(4), 1992
PMID: 1423217
Human intestinal bacteria as reservoirs for antibiotic resistance genes.
Salyers AA, Gupta A, Wang Y., Trends Microbiol. 12(9), 2004
PMID: 15337162
Antibiotic resistance in food lactic acid bacteria--a review.
Mathur S, Singh R., Int. J. Food Microbiol. 105(3), 2005
PMID: 16289406
Epidemiology of resistance to antibiotics. Links between animals and humans.
van den Bogaard AE, Stobberingh EE., Int. J. Antimicrob. Agents 14(4), 2000
PMID: 10794955

AUTHOR UNKNOWN, 1985
GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369
CRITICA: coding region identification tool invoking comparative analysis.
Badger JH, Olsen GJ, Woese CR., Mol. Biol. Evol. 16(4), 1999
PMID: 10331277
Improved microbial gene identification with GLIMMER.
Delcher AL, Harmon D, Kasif S, White O, Salzberg SL., Nucleic Acids Res. 27(23), 1999
PMID: 10556321
REGANOR: a gene prediction server for prokaryotic genomes and a database of high quality gene predictions for prokaryotes.
Linke B, McHardy AC, Neuweger H, Krause L, Meyer F., Appl. Bioinformatics 5(3), 2006
PMID: 16922601
Improved prediction of signal peptides: SignalP 3.0.
Bendtsen JD, Nielsen H, von Heijne G, Brunak S., J. Mol. Biol. 340(4), 2004
PMID: 15223320
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A, Larsson B, von Heijne G, Sonnhammer EL., J. Mol. Biol. 305(3), 2001
PMID: 11152613
Simple and rapid method for isolating large plasmid DNA from lactic streptococci.
Anderson DG, McKay LL., Appl. Environ. Microbiol. 46(3), 1983
PMID: 6416164

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 21824414
PubMed | Europe PMC

Suchen in

Google Scholar