THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING

WALCHSOLIMENA C, BLASI J, EDELMANN L, CHAPMAN ER, Fischer von Mollard G, JAHN R (1995)
JOURNAL OF CELL BIOLOGY 128(4): 637-645.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Syntaxin 1 and synaptosome-associated protein of 25 kD (SNAP-25) are neuronal plasmalemma proteins that appear to be essential for exocytosis of synaptic vesicles (SVs). Both proteins form a complex with synaptobrevin, an intrinsic membrane protein of SVs. This binding is thought to be responsible for vesicle docking and apparently precedes membrane fusion, According to the current concept, syntaxin 1 and SNAP-25 are members of larger protein families, collectively designated as target-SNAP receptors (t-SNAREs), whose specific localization to subcellular membranes define where transport vesicles bind and fuse, Here we demonstrate that major pools of syntaxin 1 and SNAP-25 recycle with SVs. Both proteins cofractionate with SVs and clathrin-coated vesicles upon subcellular fractionation. Using recombinant proteins as standards for quantitation, we found that syntaxin 1 and SNAP-25 each comprise similar to 3% of the total protein in highly purified SVs. Thus, both proteins are significant components of SVs although less abundant than synaptobrevin (8.7% of the total protein). Immunoisolation of vesicles using synaptophysin and syntaxin specific antibodies revealed that most SVs contain syntaxin 1. The widespread distribution of both syntaxin 1 and SNAP-25 on SVs was further confirmed by immunogold electron microscopy. Botulinum neurotoxin C1, a toxin that blocks exocytosis by proteolyzing syntaxin 1, preferentially cleaves vesicular syntaxin 1. We conclude that t-SNAREs participate in SV recycling in what may be functionally distinct forms.
Erscheinungsjahr
Zeitschriftentitel
JOURNAL OF CELL BIOLOGY
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128
Zeitschriftennummer
4
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637-645
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WALCHSOLIMENA C, BLASI J, EDELMANN L, CHAPMAN ER, Fischer von Mollard G, JAHN R. THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING. JOURNAL OF CELL BIOLOGY. 1995;128(4):637-645.
WALCHSOLIMENA, C., BLASI, J., EDELMANN, L., CHAPMAN, E. R., Fischer von Mollard, G., & JAHN, R. (1995). THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING. JOURNAL OF CELL BIOLOGY, 128(4), 637-645. doi:10.1083/jcb.128.4.637
WALCHSOLIMENA, C., BLASI, J., EDELMANN, L., CHAPMAN, E. R., Fischer von Mollard, G., and JAHN, R. (1995). THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING. JOURNAL OF CELL BIOLOGY 128, 637-645.
WALCHSOLIMENA, C., et al., 1995. THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING. JOURNAL OF CELL BIOLOGY, 128(4), p 637-645.
C. WALCHSOLIMENA, et al., “THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING”, JOURNAL OF CELL BIOLOGY, vol. 128, 1995, pp. 637-645.
WALCHSOLIMENA, C., BLASI, J., EDELMANN, L., CHAPMAN, E.R., Fischer von Mollard, G., JAHN, R.: THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING. JOURNAL OF CELL BIOLOGY. 128, 637-645 (1995).
WALCHSOLIMENA, C, BLASI, J, EDELMANN, L, CHAPMAN, ER, Fischer von Mollard, Gabriele, and JAHN, R. “THE T-SNARES SYNTAXIN-1 AND SNAP-25 ARE PRESENT ON ORGANELLES THAT PARTICIPATE IN SYNAPTIC VESICLE RECYCLING”. JOURNAL OF CELL BIOLOGY 128.4 (1995): 637-645.

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Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.
Littleton JT, Chapman ER, Kreber R, Garment MB, Carlson SD, Ganetzky B., Neuron 21(2), 1998
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A sequential view of neurotransmitter release.
Zheng X, Bobich JA., Brain Res Bull 47(2), 1998
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A syntaxin-SNAP 25-VAMP complex is formed without docking of synaptic vesicles.
Morel N, Taubenblatt P, Synguelakis M, Shiff G., J Physiol Paris 92(5-6), 1998
PMID: 9789843
Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes.
Prekeris R, Klumperman J, Chen YA, Scheller RH., J Cell Biol 143(4), 1998
PMID: 9817754
A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complex.
Salem N, Faúndez V, Horng JT, Kelly RB., Nat Neurosci 1(7), 1998
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Novel isoform of syntaxin 1 is expressed in mammalian cells.
Jagadish MN, Tellam JT, Macaulay SL, Gough KH, James DE, Ward CW., Biochem J 321 ( Pt 1)(), 1997
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SNAREs and regulated vesicle exocytosis.
Goda Y., Proc Natl Acad Sci U S A 94(3), 1997
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Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia.
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A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast.
Burd CG, Peterson M, Cowles CR, Emr SD., Mol Biol Cell 8(6), 1997
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The roles of NSF, SNAPs and SNAREs during membrane fusion.
Woodman PG., Biochim Biophys Acta 1357(2), 1997
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Neurotransmitter release - four years of SNARE complexes.
Hanson PI, Heuser JE, Jahn R., Curr Opin Neurobiol 7(3), 1997
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Syntaxin 6 functions in trans-Golgi network vesicle trafficking.
Bock JB, Klumperman J, Davanger S, Scheller RH., Mol Biol Cell 8(7), 1997
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Immunocytochemical localization of synaptic proteins at vesicular organelles in PC12 cells.
Marxen M, Maienschein V, Volknandt W, Zimmermann H., Neurochem Res 22(8), 1997
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SNAREs and NSF in targeted membrane fusion.
Hay JC, Scheller RH., Curr Opin Cell Biol 9(4), 1997
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Calcium regulation of neurotransmitter release: reliably unreliable?
Goda Y, Südhof TC., Curr Opin Cell Biol 9(4), 1997
PMID: 9261057
The synaptic protein syntaxin1 is required for cellularization of Drosophila embryos.
Burgess RW, Deitcher DL, Schwarz TL., J Cell Biol 138(4), 1997
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NSF and SNAP are present on adrenal chromaffin granules.
Burgoyne RD, Williams G., FEBS Lett 414(2), 1997
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Intracellular location of SNAP-25 in human neutrophils.
Nabokina S, Egea G, Blasi J, Mollinedo F., Biochem Biophys Res Commun 239(2), 1997
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Association of the fusion protein NSF with clathrin-coated vesicle membranes.
Steel GJ, Tagaya M, Woodman PG., EMBO J 15(4), 1996
PMID: 8631296
Distribution of components of the SNARE complex in relation to transmitter release sites at the frog neuromuscular junction.
Boudier JA, Charvin N, Boudier JL, Fathallah M, Tagaya M, Takahashi M, Seagar MJ., Eur J Neurosci 8(3), 1996
PMID: 8963446
Evidence that syntaxin 1A is involved in storage in the secretory pathway.
Bittner MA, Bennett MK, Holz RW., J Biol Chem 271(19), 1996
PMID: 8626670
Growth cone collapse and inhibition of neurite growth by Botulinum neurotoxin C1: a t-SNARE is involved in axonal growth.
Igarashi M, Kozaki S, Terakawa S, Kawano S, Ide C, Komiya Y., J Cell Biol 134(1), 1996
PMID: 8698815
Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport.
Volchuk A, Wang Q, Ewart HS, Liu Z, He L, Bennett MK, Klip A., Mol Biol Cell 7(7), 1996
PMID: 8862521
Rat and gerbil pinealocytes contain the synaptosomal-associated protein 25 (SNAP-25).
Redecker P, Weyer C, Grube D., J Pineal Res 21(1), 1996
PMID: 8836961
SNAP-25 is present on chromaffin granules and acts as a SNAP receptor.
Tagaya M, Genma T, Yamamoto A, Kozaki S, Mizushima S., FEBS Lett 394(1), 1996
PMID: 8925933
Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells.
Low SH, Chapin SJ, Weimbs T, Kömüves LG, Bennett MK, Mostov KE., Mol Biol Cell 7(12), 1996
PMID: 8970161
Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells.
Gaisano HY, Ghai M, Malkus PN, Sheu L, Bouquillon A, Bennett MK, Trimble WS., Mol Biol Cell 7(12), 1996
PMID: 8970162
Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein.
Timmers KI, Clark AE, Omatsu-Kanbe M, Whiteheart SW, Bennett MK, Holman GD, Cushman SW., Biochem J 320 ( Pt 2)(), 1996
PMID: 8973549
Vesicle-associated proteins and calcium in nerve terminals of chick ciliary ganglia during development of facilitation.
Lin YQ, Brain KL, Nichol KA, Morgan JJ, Bennett MR., J Physiol 497 ( Pt 3)(), 1996
PMID: 9003550
Molecular mechanisms of protein-mediated membrane fusion.
Hughson FM., Curr Opin Struct Biol 5(4), 1995
PMID: 8528767
Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis.
Chamberlain LH, Roth D, Morgan A, Burgoyne RD., J Cell Biol 130(5), 1995
PMID: 7657692
Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.
Newman LS, McKeever MO, Okano HJ, Darnell RB., Cell 82(5), 1995
PMID: 7671305
The neuronal exocytotic fusion machine: some new developments.
Chapman ER, Hanson PI, Jahn R., Neuropharmacology 34(11), 1995
PMID: 8606783
Development of cell polarity in budding yeast.
Govindan B, Novick P., J Exp Zool 273(5), 1995
PMID: 8576696

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