Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine

Miech C, Dierks T, Selmer T, Figura von K, Schmidt B (1998)
JOURNAL OF BIOLOGICAL CHEMISTRY 273(9): 4835-4837.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Eukaryotic sulfatases share an unusual posttranslational protein modification, which converts a cysteine into alpha-formylglycine. The alpha-formylglycine is essential for the catalytic activity. Klebsiella pneumoniae expresses an inducible arylsulfatase for which the DNA predicts a serine at the position occupied by the alpha-formylglycine residue in eukaryotic sulfatases. Structural analysis showed that the majority of the arylsulfatase polypeptides from K. pneumoniae carries the alpha-formylglycine, whereas the remaining arylsulfatase polypeptides contain the predicted serine residue. This demonstrates the evolutionary conservation between prokaryotes and eukaryotes of this novel protein modification that so far has been found only in sulfatases. alpha-Formylglycine in Klebsiella is generated from a serine and not from a cysteine as in eukaryotes.
Erscheinungsjahr
Zeitschriftentitel
JOURNAL OF BIOLOGICAL CHEMISTRY
Band
273
Zeitschriftennummer
9
Seite
4835-4837
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PUB-ID

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Miech C, Dierks T, Selmer T, Figura von K, Schmidt B. Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine. JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(9):4835-4837.
Miech, C., Dierks, T., Selmer, T., Figura von, K., & Schmidt, B. (1998). Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine. JOURNAL OF BIOLOGICAL CHEMISTRY, 273(9), 4835-4837. doi:10.1074/jbc.273.9.4835
Miech, C., Dierks, T., Selmer, T., Figura von, K., and Schmidt, B. (1998). Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine. JOURNAL OF BIOLOGICAL CHEMISTRY 273, 4835-4837.
Miech, C., et al., 1998. Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine. JOURNAL OF BIOLOGICAL CHEMISTRY, 273(9), p 4835-4837.
C. Miech, et al., “Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine”, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, 1998, pp. 4835-4837.
Miech, C., Dierks, T., Selmer, T., Figura von, K., Schmidt, B.: Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine. JOURNAL OF BIOLOGICAL CHEMISTRY. 273, 4835-4837 (1998).
Miech, C, Dierks, Thomas, Selmer, T, Figura von, K, and Schmidt, B. “Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine”. JOURNAL OF BIOLOGICAL CHEMISTRY 273.9 (1998): 4835-4837.

37 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.
Hanson SR, Best MD, Wong CH., Angew Chem Int Ed Engl 43(43), 2004
PMID: 15493058
Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme.
Dierks T, Schmidt B, Borissenko LV, Peng J, Preusser A, Mariappan M, von Figura K., Cell 113(4), 2003
PMID: 12757705
1.3 A structure of arylsulfatase from Pseudomonas aeruginosa establishes the catalytic mechanism of sulfate ester cleavage in the sulfatase family.
Boltes I, Czapinska H, Kahnert A, von Bülow R, Dierks T, Schmidt B, von Figura K, Kertesz MA, Usón I., Structure 9(6), 2001
PMID: 11435113
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Okeley NM, van der Donk WA., Chem Biol 7(7), 2000
PMID: 10903941
Escherichia coli K1 aslA contributes to invasion of brain microvascular endothelial cells in vitro and in vivo.
Hoffman JA, Badger JL, Zhang Y, Huang SH, Kim KS., Infect Immun 68(9), 2000
PMID: 10948126
Sequence determinants directing conversion of cysteine to formylglycine in eukaryotic sulfatases.
Dierks T, Lecca MR, Schlotterhose P, Schmidt B, von Figura K., EMBO J 18(8), 1999
PMID: 10205163
A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease.
von Figura K, Schmidt B, Selmer T, Dierks T., Bioessays 20(6), 1998
PMID: 9699462

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