Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels

Gröger H, Capan E, Barthuber A, Vorlop KD (2001)
Organic Letters 3(13): 1969-1972.

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[structure: see text] A novel synthesis of (R)-cyanohydrins is described which is based on the use of cross-linked and subsequently poly(vinyl alcohol)-entrapped (R)-oxynitrilases. These immobilized lens-shaped biocatalysts have a well-defined macroscopic size in the mm range, show no catalyst leaching, and can be recycled efficiently. Furthermore, this immobilization method is cheap and the entrapped (R)-oxynitrilases gave similar good results compared with those of free enzymes. The (R)-cyanohydrin was obtained in good yields and with high enantioselectivities of up to >99% ee.
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Gröger H, Capan E, Barthuber A, Vorlop KD. Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters. 2001;3(13):1969-1972.
Gröger, H., Capan, E., Barthuber, A., & Vorlop, K. D. (2001). Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters, 3(13), 1969-1972.
Gröger, H., Capan, E., Barthuber, A., and Vorlop, K. D. (2001). Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters 3, 1969-1972.
Gröger, H., et al., 2001. Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters, 3(13), p 1969-1972.
H. Gröger, et al., “Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels”, Organic Letters, vol. 3, 2001, pp. 1969-1972.
Gröger, H., Capan, E., Barthuber, A., Vorlop, K.D.: Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters. 3, 1969-1972 (2001).
Gröger, Harald, Capan, E, Barthuber, A, and Vorlop, K D. “Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels”. Organic Letters 3.13 (2001): 1969-1972.
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