The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids

Gröger H, Trauthwein H, Buchholz S, Drauz K, Sacherer C, Godfrin S, Werner H (2004)
Org. Biomol. Chemistry 2(14): 1977-1978.

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The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids is reported. The presence of an N-chloroacetyl group as acyl group in the substrate as well as the use of porcine kidney acylase I as a suitable enzyme component are prerequisites for this resolution process whereby optically active beta-amino acids are formed with high enantioselectivities of >98% ee.
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Gröger H, Trauthwein H, Buchholz S, et al. The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids. Org. Biomol. Chemistry. 2004;2(14):1977-1978.
Gröger, H., Trauthwein, H., Buchholz, S., Drauz, K., Sacherer, C., Godfrin, S., & Werner, H. (2004). The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids. Org. Biomol. Chemistry, 2(14), 1977-1978.
Gröger, H., Trauthwein, H., Buchholz, S., Drauz, K., Sacherer, C., Godfrin, S., and Werner, H. (2004). The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids. Org. Biomol. Chemistry 2, 1977-1978.
Gröger, H., et al., 2004. The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids. Org. Biomol. Chemistry, 2(14), p 1977-1978.
H. Gröger, et al., “The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids”, Org. Biomol. Chemistry, vol. 2, 2004, pp. 1977-1978.
Gröger, H., Trauthwein, H., Buchholz, S., Drauz, K., Sacherer, C., Godfrin, S., Werner, H.: The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids. Org. Biomol. Chemistry. 2, 1977-1978 (2004).
Gröger, Harald, Trauthwein, Harald, Buchholz, Stefan, Drauz, Karlheinz, Sacherer, Christiane, Godfrin, Sylvie, and Werner, Helge. “The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids”. Org. Biomol. Chemistry 2.14 (2004): 1977-1978.
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