Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol

Chamouleau F, Hagedorn C, May O, Gröger H (2007)
FLAVOUR AND FRAGRANCE JOURNAL 22(3): 169-172.

Journal Article | Published | English

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Abstract
A biocatalytic method for the synthesis of the aroma chemical cinnamyl alcohol by means of a whole-cell-catalysed reduction of cinnamyl aldehyde has been developed. As a biocatalyst, recombinant whole cells overexpressing an alcohol dehydrogenase from Lactobacillus kefir and a glucose dehydrogenase from Thermoplasma acidophilum have been used in combination with D-glucose as co-substrate. The reduction process proceeds with a conversion of 98%, even at a high substrate input of 166 g/l cinnamyl aldehyde, and gives a yield of 77% of the desired product, cinnamyl alcohol. In addition to high product concentrations, further advantages of this approach are the use of a low-cost whole-cell catalyst, the high purity of the product, as well as the fact that there is no need for the addition of external co-factor in the biotransformation step. Copyright (C) 2007 John Wiley & Sons, Ltd.
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Chamouleau F, Hagedorn C, May O, Gröger H. Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol. FLAVOUR AND FRAGRANCE JOURNAL. 2007;22(3):169-172.
Chamouleau, F., Hagedorn, C., May, O., & Gröger, H. (2007). Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol. FLAVOUR AND FRAGRANCE JOURNAL, 22(3), 169-172.
Chamouleau, F., Hagedorn, C., May, O., and Gröger, H. (2007). Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol. FLAVOUR AND FRAGRANCE JOURNAL 22, 169-172.
Chamouleau, F., et al., 2007. Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol. FLAVOUR AND FRAGRANCE JOURNAL, 22(3), p 169-172.
F. Chamouleau, et al., “Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol”, FLAVOUR AND FRAGRANCE JOURNAL, vol. 22, 2007, pp. 169-172.
Chamouleau, F., Hagedorn, C., May, O., Gröger, H.: Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol. FLAVOUR AND FRAGRANCE JOURNAL. 22, 169-172 (2007).
Chamouleau, Francoise, Hagedorn, Chad, May, Oliver, and Gröger, Harald. “Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol”. FLAVOUR AND FRAGRANCE JOURNAL 22.3 (2007): 169-172.
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