Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction

Krausser M, Hummel W, Gröger H (2007)
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007(31): 5175-5179.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
A one-pot two-step process for the enantioselective synthesis of hydrophobic allylic alcohols was developed, which comprises ketone formation by the Wittig reaction and their enzymatic in situ biotransformation into the desired target products. By means of this combined Wittig reaction and bioreduction, the allylic alcohols were prepared with conversions of up to 90 %, and with excellent enantio selectivities of >99 % ee. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).
Erscheinungsjahr
Zeitschriftentitel
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Band
2007
Zeitschriftennummer
31
Seite
5175-5179
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eISSN
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Krausser M, Hummel W, Gröger H. Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2007;2007(31):5175-5179.
Krausser, M., Hummel, W., & Gröger, H. (2007). Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007(31), 5175-5179. doi:10.1002/ejoc.200700647
Krausser, M., Hummel, W., and Gröger, H. (2007). Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007, 5175-5179.
Krausser, M., Hummel, W., & Gröger, H., 2007. Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007(31), p 5175-5179.
M. Krausser, W. Hummel, and H. Gröger, “Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction”, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2007, 2007, pp. 5175-5179.
Krausser, M., Hummel, W., Gröger, H.: Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2007, 5175-5179 (2007).
Krausser, Marina, Hummel, Werner, and Gröger, Harald. “Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007.31 (2007): 5175-5179.