Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes

Dominguez de Maria P, Pohl M, Gocke D, Gröger H, Trauthwein H, Stillger T, Walter L, Mueller M (2007)
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007(18): 2940-2944.

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Abstract
Benzaldehyde lyase (BAL) and benzoylformate decarboxylase (BFD) catalyse the asymmetric ligation of aliphatic aldehydes to afford enantiomerically enriched 2-hydroxy ketones. Carboligation of linear aldehydes with both enzymes results in high levels of conversion and in enantioselectivities of up to 80 % ee. In cases involving branched aliphatic aldehydes, BAL enables the carboligation of 3-methylbutanal with a high level of conversion and an enantioselectivity of 89 % ee. ((c) Wiley-VCH Verlag GmbH & Co.
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Dominguez de Maria P, Pohl M, Gocke D, et al. Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2007;2007(18):2940-2944.
Dominguez de Maria, P., Pohl, M., Gocke, D., Gröger, H., Trauthwein, H., Stillger, T., Walter, L., et al. (2007). Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007(18), 2940-2944.
Dominguez de Maria, P., Pohl, M., Gocke, D., Gröger, H., Trauthwein, H., Stillger, T., Walter, L., and Mueller, M. (2007). Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007, 2940-2944.
Dominguez de Maria, P., et al., 2007. Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007(18), p 2940-2944.
P. Dominguez de Maria, et al., “Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes”, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2007, 2007, pp. 2940-2944.
Dominguez de Maria, P., Pohl, M., Gocke, D., Gröger, H., Trauthwein, H., Stillger, T., Walter, L., Mueller, M.: Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2007, 2940-2944 (2007).
Dominguez de Maria, Pablo, Pohl, Martina, Gocke, Doerte, Gröger, Harald, Trauthwein, Harald, Stillger, Thomas, Walter, Lydia, and Mueller, Michael. “Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007.18 (2007): 2940-2944.
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