Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules

Burda E, Krausser M, Fischer G, Hummel W, Mueller-Uri F, Kreis W, Gröger H (2009)
ADVANCED SYNTHESIS & CATALYSIS 351(17): 2787-2790.

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Abstract
It was found that Delta(4,5)-steroid 5 beta-reductases are capable of reducing also small molecules bearing an activated C=C double bond such as monocyclic enones and acyclic enoate esters. As preferred Delta(4,5)-steroid 5 beta-reductase (5 beta-StR) for this purpose, 5 beta-StR from Arabidopsis thaliana was used. In part. enzyme activities are even higher than that for progesterone. Successful preliminary biotransformations with enzymatic in situ cofactor recycling were also carried out. When using the prochiral compound isophorone as a substrate, a high enantioselective reaction course (>99% ee) was observed.
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Burda E, Krausser M, Fischer G, et al. Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS. 2009;351(17):2787-2790.
Burda, E., Krausser, M., Fischer, G., Hummel, W., Mueller-Uri, F., Kreis, W., & Gröger, H. (2009). Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS, 351(17), 2787-2790.
Burda, E., Krausser, M., Fischer, G., Hummel, W., Mueller-Uri, F., Kreis, W., and Gröger, H. (2009). Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS 351, 2787-2790.
Burda, E., et al., 2009. Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS, 351(17), p 2787-2790.
E. Burda, et al., “Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules”, ADVANCED SYNTHESIS & CATALYSIS, vol. 351, 2009, pp. 2787-2790.
Burda, E., Krausser, M., Fischer, G., Hummel, W., Mueller-Uri, F., Kreis, W., Gröger, H.: Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS. 351, 2787-2790 (2009).
Burda, Edyta, Krausser, Marina, Fischer, Gabriele, Hummel, Werner, Mueller-Uri, Frieder, Kreis, Wolfgang, and Gröger, Harald. “Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules”. ADVANCED SYNTHESIS & CATALYSIS 351.17 (2009): 2787-2790.
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