Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols

Burda E, Bauer W, Hummel W, Gröger H (2010)
CHEMCATCHEM 2(1): 67-72.

Journal Article | Published | English

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Abstract
An enantio- and diastereoselective synthesis of C2-symmetric diols bearing a biphenyl-framework has been developed by means of an enzymatic reduction of the corresponding diketones, which were prepared by a Suzuki coupling reaction. It Furthermore, a chemoenzymatic one-pot synthesis of a C2-symmetric diol in aqueous media has been realized through combination of the Suzuki coupling reaction and enzymatic reduction. Chiral stereoisomers of the biaryl-containing diols are prepared with diastereomeric ratios in excess of 25:1 and enantiomeric excesses of greater than 99%.
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Burda E, Bauer W, Hummel W, Gröger H. Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols. CHEMCATCHEM. 2010;2(1):67-72.
Burda, E., Bauer, W., Hummel, W., & Gröger, H. (2010). Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols. CHEMCATCHEM, 2(1), 67-72.
Burda, E., Bauer, W., Hummel, W., and Gröger, H. (2010). Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols. CHEMCATCHEM 2, 67-72.
Burda, E., et al., 2010. Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols. CHEMCATCHEM, 2(1), p 67-72.
E. Burda, et al., “Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols”, CHEMCATCHEM, vol. 2, 2010, pp. 67-72.
Burda, E., Bauer, W., Hummel, W., Gröger, H.: Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols. CHEMCATCHEM. 2, 67-72 (2010).
Burda, Edyta, Bauer, Walter, Hummel, Werner, and Gröger, Harald. “Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols”. CHEMCATCHEM 2.1 (2010): 67-72.
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