Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones

Neupert A, Ress T, Wittmann J, Hummel W, Gröger H (2010)
Zeitschrift für Naturforschung. Section B, a journal of chemical sciences 65(3): 337-340.

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Abstract
Direct enantioselective reduction of 2'-, 3'- and 4'-hydroxyacetophenone without protection of the hydroxy moiety was carried out in the presence of (R)- and (S)-alcohol dehydrogenases as biocatalysts. Whereas reduction of 2'-hydroxyacetophenone gave only low to medium conversions, reduction of 3'- and 4'-hydroxyacetophenone proceeded efficiently leading to the resulting 1-(3-hydroxyphenyl)ethan-1 -ol and 1-(4-hydroxyphenypethan- 1-01 with high conversion (up to > 95%) and excellent enantioselectivity (up to > 99% cc).
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Neupert A, Ress T, Wittmann J, Hummel W, Gröger H. Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences. 2010;65(3):337-340.
Neupert, A., Ress, T., Wittmann, J., Hummel, W., & Gröger, H. (2010). Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences, 65(3), 337-340.
Neupert, A., Ress, T., Wittmann, J., Hummel, W., and Gröger, H. (2010). Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences 65, 337-340.
Neupert, A., et al., 2010. Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences, 65(3), p 337-340.
A. Neupert, et al., “Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones”, Zeitschrift für Naturforschung. Section B, a journal of chemical sciences, vol. 65, 2010, pp. 337-340.
Neupert, A., Ress, T., Wittmann, J., Hummel, W., Gröger, H.: Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences. 65, 337-340 (2010).
Neupert, Adrian, Ress, Tina, Wittmann, Jürgen, Hummel, Werner, and Gröger, Harald. “Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones”. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences 65.3 (2010): 337-340.
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