Enantioselective biocatalytic synthesis of (S)-monastrol

Alfaro Blasco M, Thumann S, Wittmann J, Athanassios G, Gröger H (2010)
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(15): 4679-4682.

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Abstract
The first enantioselective biocatalytic synthesis of (S)-monastrol has been developed via an unexpected and unusual enzymatic pathway as suitable route. Whereas attempts for a direct hydrolysis of racemic monastrol were not successful, formation of racemic O-butanoyl monastrol and subsequent enantioselective hydrolysis furnished O-butanoyl (S)-monastrol with 97% ee. Cleavage of the O-butanoyl moiety then gave the desired (S)-monastrol with 96% ee. (C) 2010 Elsevier Ltd. All rights reserved.
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Alfaro Blasco M, Thumann S, Wittmann J, Athanassios G, Gröger H. Enantioselective biocatalytic synthesis of (S)-monastrol. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2010;20(15):4679-4682.
Alfaro Blasco, M., Thumann, S., Wittmann, J., Athanassios, G., & Gröger, H. (2010). Enantioselective biocatalytic synthesis of (S)-monastrol. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(15), 4679-4682.
Alfaro Blasco, M., Thumann, S., Wittmann, J., Athanassios, G., and Gröger, H. (2010). Enantioselective biocatalytic synthesis of (S)-monastrol. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20, 4679-4682.
Alfaro Blasco, M., et al., 2010. Enantioselective biocatalytic synthesis of (S)-monastrol. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(15), p 4679-4682.
M. Alfaro Blasco, et al., “Enantioselective biocatalytic synthesis of (S)-monastrol”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pp. 4679-4682.
Alfaro Blasco, M., Thumann, S., Wittmann, J., Athanassios, G., Gröger, H.: Enantioselective biocatalytic synthesis of (S)-monastrol. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 20, 4679-4682 (2010).
Alfaro Blasco, Maria, Thumann, Silvia, Wittmann, Juergen, Athanassios, Giannis, and Gröger, Harald. “Enantioselective biocatalytic synthesis of (S)-monastrol”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.15 (2010): 4679-4682.
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