Intracellular pH sensors based on surface-enhanced Raman scattering

Talley CE, Jusinski L, Hollars CW, Lane SM, Huser T (2004)
Analytical Chemistry 76(23): 7064-7068.

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Journal Article | Original Article | Published | English

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Fakultät für Physik > AG Laserphysik und Laserspektroskopie
Abstract
We present the development of nanoscale pH sensors based on functionalized silver nanoparticles and surface-enhanced Raman scattering (SERS). The SERS spectrum from individual silver nanoparticle (50-80 nm in diameter) clusters functionalized with 4-mercaptobenzoic acid shows a characteristic response to the pH of the surrounding solution and is sensitive to pH changes in the range of 6-8. Measurements from nanoparticles incorporated in living Chinese hamster ovary cells demonstrate that the nanoparticle sensors retain their robust signal and sensitivity to pH when incorporated into a cell.
Publishing Year
2004
ISSN
0003-2700
eISSN
1520-6882
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Talley CE, Jusinski L, Hollars CW, Lane SM, Huser T. Intracellular pH sensors based on surface-enhanced Raman scattering. Analytical Chemistry. 2004;76(23):7064-7068.
Talley, C. E., Jusinski, L., Hollars, C. W., Lane, S. M., & Huser, T. (2004). Intracellular pH sensors based on surface-enhanced Raman scattering. Analytical Chemistry, 76(23), 7064-7068. doi:10.1021/ac049093j
Talley, C. E., Jusinski, L., Hollars, C. W., Lane, S. M., and Huser, T. (2004). Intracellular pH sensors based on surface-enhanced Raman scattering. Analytical Chemistry 76, 7064-7068.
Talley, C.E., et al., 2004. Intracellular pH sensors based on surface-enhanced Raman scattering. Analytical Chemistry, 76(23), p 7064-7068.
C.E. Talley, et al., “Intracellular pH sensors based on surface-enhanced Raman scattering”, Analytical Chemistry, vol. 76, 2004, pp. 7064-7068.
Talley, C.E., Jusinski, L., Hollars, C.W., Lane, S.M., Huser, T.: Intracellular pH sensors based on surface-enhanced Raman scattering. Analytical Chemistry. 76, 7064-7068 (2004).
Talley, C. E., Jusinski, L., Hollars, C. W., Lane, S. M., and Huser, Thomas. “Intracellular pH sensors based on surface-enhanced Raman scattering”. Analytical Chemistry 76.23 (2004): 7064-7068.
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