Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level

Walhorn V, Schröder T, Mattay J, Anselmetti D (In Press)
Nanoscale 3(11): 4859-4865.

Journal Article | In Press | English

No fulltext has been uploaded

Abstract
Surface-immobilized and switchable resorcin[4]arene receptor molecules were quantitatively investigated with atomic force microscopy (AFM) and AFM-single molecule force spectroscopy (AFM-SMFS). The upper rim of the supramolecular receptor cavities was modified with two photodimerizable anthracene moieties. The molecular constitution can be externally switched and controlled by exposure to ultraviolet (UV) light and heat. The topography as well as the complexation affinity against small ammonium guest ions of the two isomers were investigated at the single molecule level. Our results demonstrate the feasibility to externally control the supramolecular receptor's affinity and simultaneously quantify and associate these binding properties with the structural change of the resorcin[4]arenes structure on the basis of the measured molecule corrugation height.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Walhorn V, Schröder T, Mattay J, Anselmetti D. Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level. Nanoscale. In Press;3(11):4859-4865.
Walhorn, V., Schröder, T., Mattay, J., & Anselmetti, D. (In Press). Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level. Nanoscale, 3(11), 4859-4865.
Walhorn, V., Schröder, T., Mattay, J., and Anselmetti, D. (In Press). Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level. Nanoscale 3, 4859-4865.
Walhorn, V., et al., In Press. Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level. Nanoscale, 3(11), p 4859-4865.
V. Walhorn, et al., “Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level”, Nanoscale, vol. 3, In Press, pp. 4859-4865.
Walhorn, V., Schröder, T., Mattay, J., Anselmetti, D.: Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level. Nanoscale. 3, 4859-4865 (In Press).
Walhorn, Volker, Schröder, Tobias, Mattay, Jochen, and Anselmetti, Dario. “Functional Characterization of a Supramolecular Affinity Switch at the Single Molecule Level”. Nanoscale 3.11 (In Press): 4859-4865.
This data publication is cited in the following publications:
This publication cites the following data publications:

4 Citations in Europe PMC

Data provided by Europe PubMed Central.

Mechanical stability of bivalent transition metal complexes analyzed by single-molecule force spectroscopy.
Gensler M, Eidamshaus C, Taszarek M, Reissig HU, Rabe JP., Beilstein J Org Chem 11(), 2015
PMID: 26124883
Catch bond interaction between cell-surface sulfatase Sulf1 and glycosaminoglycans.
Harder A, Moller AK, Milz F, Neuhaus P, Walhorn V, Dierks T, Anselmetti D., Biophys. J. 108(7), 2015
PMID: 25863062
Reversible control over molecular recognition in surface-bound photoswitchable hydrogen-bonding receptors: towards read-write-erase molecular printboards.
Liang CK, Dubacheva GV, Buffeteau T, Cavagnat D, Hapiot P, Fabre B, Tucker JH, Bassani DM., Chemistry 19(38), 2013
PMID: 23929495

42 References

Data provided by Europe PubMed Central.


Hegner, Surf. Sci. 291(), 1993

Wagner, Langmuir 11(), 1995

Eckel, Proc. SPIE–Int. Soc. Opt. Eng. 6092(), 2006

Hutter, Rev. Sci. Instrum. 64(), 1993
Dynamic strength of molecular adhesion bonds.
Evans E, Ritchie K., Biophys. J. 72(4), 1997
PMID: 9083660
Model energy landscapes and the force-induced dissociation of ligand-receptor bonds.
Strunz T, Oroszlan K, Schumakovitch I, Guntherodt H, Hegner M., Biophys. J. 79(3), 2000
PMID: 10968985
Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes.
Raible M, Evstigneev M, Reimann P, Bartels FW, Ros R., J. Biotechnol. 112(1-2), 2004
PMID: 15288937
Theoretical analysis of single-molecule force spectroscopy experiments: heterogeneity of chemical bonds.
Raible M, Evstigneev M, Bartels FW, Eckel R, Nguyen-Duong M, Merkel R, Ros R, Anselmetti D, Reimann P., Biophys. J. 90(11), 2006
PMID: 16513778

Getfert, Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. 76(), 2007

Fuhrmann, Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. 77(), 2008

Ahmed, Acta Crystallogr. 5(), 1952

Bouas-Laurent, Chem. Soc. Rev. 29(), 2000
Unbinding forces of single antibody-antigen complexes correlate with their thermal dissociation rates.
Schwesinger F, Ros R, Strunz T, Anselmetti D, Guntherodt HJ, Honegger A, Jermutus L, Tiefenauer L, Pluckthun A., Proc. Natl. Acad. Sci. U.S.A. 97(18), 2000
PMID: 10963664

Haino, Chem.–Eur. J. 6(), 2000

Kramers, Physica 7(), 1940

Schäfer, Pure Appl. Chem. 78(), 2006

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 22009325
PubMed | Europe PMC

Search this title in

Google Scholar