O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)

Happi EN, Waffo AFK, Wansi JD, Ngadjui BT, Sewald N (2011)
Planta Medica 77(09): 934-938.

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Abstract
Two new O-prenylated acridone alkaloids, balsacridone A (1) and B (2), together with eighteen known compounds were isolated from the methanol extract from the stems of Balsamocitrus paniculata, a Cameroonian medicinal plant. The structures of all compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral (EI and ESI) data, and chemical reactions. N-methyl-6-methoxybenzoxazolinone (16) was isolated for the first time from a natural source while compounds 13, 14, and 15 for the first time from this genus. Pure compounds were tested for their activity against bacteria, fungi, and plant pathogen oomycetes, using the paper disk agar diffusion assay. The agar diffusion test delivered low to missing antimicrobial activities, corresponding to MICs > 1 mg/mL. However, compounds 1-15 exhibited a strong suppressive effect on phagocytosis response upon activation with serum opsonized zymosan in the range of IC(50) = 0.5-7.2 mu M, and the acridone alkaloids (1-5), N-trans- p-coumaroyltyramine (13), and N-trans-p-coumaroyloctopamine (14) displayed weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3, with IC(50) values ranging from 69.8 to 99.0 mu M.
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Happi EN, Waffo AFK, Wansi JD, Ngadjui BT, Sewald N. O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica. 2011;77(09):934-938.
Happi, E. N., Waffo, A. F. K., Wansi, J. D., Ngadjui, B. T., & Sewald, N. (2011). O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica, 77(09), 934-938.
Happi, E. N., Waffo, A. F. K., Wansi, J. D., Ngadjui, B. T., and Sewald, N. (2011). O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica 77, 934-938.
Happi, E.N., et al., 2011. O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica, 77(09), p 934-938.
E.N. Happi, et al., “O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)”, Planta Medica, vol. 77, 2011, pp. 934-938.
Happi, E.N., Waffo, A.F.K., Wansi, J.D., Ngadjui, B.T., Sewald, N.: O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica. 77, 934-938 (2011).
Happi, Emmanuel Ngeufa, Waffo, Alain Francois Kamdem, Wansi, Jean Duplex, Ngadjui, Bonaventure Tchaleu, and Sewald, Norbert. “O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)”. Planta Medica 77.09 (2011): 934-938.
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Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification.
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PMID: 23802859
Muscarine, imidaozle, oxazole and thiazole alkaloids.
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PMID: 23644572

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