O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)

Happi EN, Waffo AFK, Wansi JD, Ngadjui BT, Sewald N (2011)
Planta Medica 77(09): 934-938.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Two new O-prenylated acridone alkaloids, balsacridone A (1) and B (2), together with eighteen known compounds were isolated from the methanol extract from the stems of Balsamocitrus paniculata, a Cameroonian medicinal plant. The structures of all compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral (EI and ESI) data, and chemical reactions. N-methyl-6-methoxybenzoxazolinone (16) was isolated for the first time from a natural source while compounds 13, 14, and 15 for the first time from this genus. Pure compounds were tested for their activity against bacteria, fungi, and plant pathogen oomycetes, using the paper disk agar diffusion assay. The agar diffusion test delivered low to missing antimicrobial activities, corresponding to MICs > 1 mg/mL. However, compounds 1-15 exhibited a strong suppressive effect on phagocytosis response upon activation with serum opsonized zymosan in the range of IC(50) = 0.5-7.2 mu M, and the acridone alkaloids (1-5), N-trans- p-coumaroyltyramine (13), and N-trans-p-coumaroyloctopamine (14) displayed weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3, with IC(50) values ranging from 69.8 to 99.0 mu M.
Erscheinungsjahr
Zeitschriftentitel
Planta Medica
Band
77
Zeitschriftennummer
09
Seite
934-938
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Happi EN, Waffo AFK, Wansi JD, Ngadjui BT, Sewald N. O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica. 2011;77(09):934-938.
Happi, E. N., Waffo, A. F. K., Wansi, J. D., Ngadjui, B. T., & Sewald, N. (2011). O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica, 77(09), 934-938. doi:10.1055/s-0030-1250692
Happi, E. N., Waffo, A. F. K., Wansi, J. D., Ngadjui, B. T., and Sewald, N. (2011). O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica 77, 934-938.
Happi, E.N., et al., 2011. O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica, 77(09), p 934-938.
E.N. Happi, et al., “O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)”, Planta Medica, vol. 77, 2011, pp. 934-938.
Happi, E.N., Waffo, A.F.K., Wansi, J.D., Ngadjui, B.T., Sewald, N.: O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica. 77, 934-938 (2011).
Happi, Emmanuel Ngeufa, Waffo, Alain Francois Kamdem, Wansi, Jean Duplex, Ngadjui, Bonaventure Tchaleu, and Sewald, Norbert. “O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)”. Planta Medica 77.09 (2011): 934-938.

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Fomani M, Ngeufa Happi E, Nouga Bisoue A, Ndom JC, Kamdem Waffo AF, Sewald N, Wansi JD., Bioorg Med Chem Lett 26(2), 2016
PMID: 26711890
Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants.
Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM., Drug Des Devel Ther 10(), 2016
PMID: 27445461
Muscarine, imidaozle, oxazole and thiazole alkaloids.
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Ntie-Kang F, Lifongo LL, Mbaze LM, Ekwelle N, Owono Owono LC, Megnassan E, Judson PN, Sippl W, Efange SM., BMC Complement Altern Med 13(), 2013
PMID: 23802859

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