FACIL: Fast and Accurate Genetic Code Inference and Logo

Dutilh BE, Jurgelenaite R, Szklarczyk R, van Hijum SAFT, Harhangi HR, Schmid M, de Wild B, Francoijs K-J, Stunnenberg HG, Strous M, Jetten MSM, et al. (2011)
Bioinformatics 27(14): 1929-1933.

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Abstract / Bemerkung
Motivation: The intensification of DNA sequencing will increasingly unveil uncharacterized species with potential alternative genetic codes. A total of 0.65% of the DNA sequences currently in Genbank encode their proteins with a variant genetic code, and these exceptions occur in many unrelated taxa. Results: We introduce FACIL (Fast and Accurate genetic Code Inference and Logo), a fast and reliable tool to evaluate nucleic acid sequences for their genetic code that detects alternative codes even in species distantly related to known organisms. To illustrate this, we apply FACIL to a set of mitochondrial genomic contigs of Globobulimina pseudospinescens. This foraminifer does not have any sequenced close relative in the databases, yet we infer its alternative genetic code with high confidence values. Results are intuitively visualized in a Genetic Code Logo.
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Bioinformatics
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27
Zeitschriftennummer
14
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1929-1933
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Dutilh BE, Jurgelenaite R, Szklarczyk R, et al. FACIL: Fast and Accurate Genetic Code Inference and Logo. Bioinformatics. 2011;27(14):1929-1933.
Dutilh, B. E., Jurgelenaite, R., Szklarczyk, R., van Hijum, S. A. F. T., Harhangi, H. R., Schmid, M., de Wild, B., et al. (2011). FACIL: Fast and Accurate Genetic Code Inference and Logo. Bioinformatics, 27(14), 1929-1933. doi:10.1093/bioinformatics/btr316
Dutilh, B. E., Jurgelenaite, R., Szklarczyk, R., van Hijum, S. A. F. T., Harhangi, H. R., Schmid, M., de Wild, B., Francoijs, K. - J., Stunnenberg, H. G., Strous, M., et al. (2011). FACIL: Fast and Accurate Genetic Code Inference and Logo. Bioinformatics 27, 1929-1933.
Dutilh, B.E., et al., 2011. FACIL: Fast and Accurate Genetic Code Inference and Logo. Bioinformatics, 27(14), p 1929-1933.
B.E. Dutilh, et al., “FACIL: Fast and Accurate Genetic Code Inference and Logo”, Bioinformatics, vol. 27, 2011, pp. 1929-1933.
Dutilh, B.E., Jurgelenaite, R., Szklarczyk, R., van Hijum, S.A.F.T., Harhangi, H.R., Schmid, M., de Wild, B., Francoijs, K.-J., Stunnenberg, H.G., Strous, M., Jetten, M.S.M., Op den Camp, H.J.M., Huynen, M.A.: FACIL: Fast and Accurate Genetic Code Inference and Logo. Bioinformatics. 27, 1929-1933 (2011).
Dutilh, Bas E., Jurgelenaite, Rasa, Szklarczyk, Radek, van Hijum, Sacha A. F. T., Harhangi, Harry R., Schmid, Markus, de Wild, Bart, Francoijs, Kees-Jan, Stunnenberg, Hendrik G., Strous, Marc, Jetten, Mike S. M., Op den Camp, Huub J. M., and Huynen, Martijn A. “FACIL: Fast and Accurate Genetic Code Inference and Logo”. Bioinformatics 27.14 (2011): 1929-1933.

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