An unexpected link between angiotensinogen and thrombin

Wang Y, Ragg H (2011)
FEBS Letters 585(14): 2395-2399.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Angiotensinogen is well known as source protein for a group of potent vasoactive hormones, however, a discrete biochemical activity of the angiotensinogen body is not known. Here we investigated angiotensinogen from the lamprey Lampetra fluviatilis (L. fluviatilis), an early-diverged vertebrate. The recombinantly produced protein showed progressive inhibitory activity towards human alpha-thrombin with a second-order rate constant of 2.6 x 10(4) M(-1) min(-1). Heparin enhanced the reaction rate > 800-fold with a bell-shaped dose-response curve and a stoichiometry of inhibition (SI) of 1.3, revealing lamprey angiotensinogen as an effective a-thrombin inhibitor. Genomic, biochemical, and protein sequence data indicate that angiotensinogen and heparin cofactor II (HCII) originated from a common ancestral thrombin antagonist, thus providing insight into an early stage of thrombin control. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
FEBS Letters
Band
585
Zeitschriftennummer
14
Seite
2395-2399
ISSN
PUB-ID

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Wang Y, Ragg H. An unexpected link between angiotensinogen and thrombin. FEBS Letters. 2011;585(14):2395-2399.
Wang, Y., & Ragg, H. (2011). An unexpected link between angiotensinogen and thrombin. FEBS Letters, 585(14), 2395-2399. doi:10.1016/j.febslet.2011.06.021
Wang, Y., and Ragg, H. (2011). An unexpected link between angiotensinogen and thrombin. FEBS Letters 585, 2395-2399.
Wang, Y., & Ragg, H., 2011. An unexpected link between angiotensinogen and thrombin. FEBS Letters, 585(14), p 2395-2399.
Y. Wang and H. Ragg, “An unexpected link between angiotensinogen and thrombin”, FEBS Letters, vol. 585, 2011, pp. 2395-2399.
Wang, Y., Ragg, H.: An unexpected link between angiotensinogen and thrombin. FEBS Letters. 585, 2395-2399 (2011).
Wang, Yunjie, and Ragg, Hermann. “An unexpected link between angiotensinogen and thrombin”. FEBS Letters 585.14 (2011): 2395-2399.

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism.
Wei H, Cai H, Wu J, Wei Z, Zhang F, Huang X, Ma L, Feng L, Zhang R, Wang Y, Ragg H, Zheng Y, Zhou A., J Biol Chem 291(48), 2016
PMID: 27681598
Revising angiotensinogen from phylogenetic and genetic variants perspectives.
Kumar A, Sarde SJ, Bhandari A., Biochem Biophys Res Commun 446(2), 2014
PMID: 24631685
Origin of serpin-mediated regulation of coagulation and blood pressure.
Wang Y, Köster K, Lummer M, Ragg H., PLoS One 9(5), 2014
PMID: 24840053
Genetic variants and evolutionary analyses of heparin cofactor II.
Kumar A, Bhandari A, Sarde SJ, Goswami C., Immunobiology 219(9), 2014
PMID: 24950623
Emergence and evolution of the renin-angiotensin-aldosterone system.
Fournier D, Luft FC, Bader M, Ganten D, Andrade-Navarro MA., J Mol Med (Berl) 90(5), 2012
PMID: 22527880

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