A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes

Chen M, Hu M, Hofestädt R (2011)
Applied Biochemistry and Biotechnology 164(3): 338-352.

Download
No fulltext has been uploaded. References only!
Journal Article | Published | English

No fulltext has been uploaded

Author
Abstract
A method to exploit hybrid Petri nets for modeling and simulating biochemical processes in a systematic way was introduced. Both molecular biology and biochemical engineering aspects are manipulated. With discrete and continuous elements, the hybrid Petri nets can easily handle biochemical factors such as metabolites concentration and kinetic behaviors. It is possible to translate both molecular biological behavior and biochemical processes workflow into hybrid Petri nets in a natural manner. As an example, penicillin production bioprocess is modeled to illustrate the concepts of the methodology. Results of the dynamic of production parameters in the bioprocess were simulated and observed diagrammatically. Current problems and post-genomic perspectives were also discussed.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Chen M, Hu M, Hofestädt R. A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes. Applied Biochemistry and Biotechnology. 2011;164(3):338-352.
Chen, M., Hu, M., & Hofestädt, R. (2011). A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes. Applied Biochemistry and Biotechnology, 164(3), 338-352.
Chen, M., Hu, M., and Hofestädt, R. (2011). A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes. Applied Biochemistry and Biotechnology 164, 338-352.
Chen, M., Hu, M., & Hofestädt, R., 2011. A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes. Applied Biochemistry and Biotechnology, 164(3), p 338-352.
M. Chen, M. Hu, and R. Hofestädt, “A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes”, Applied Biochemistry and Biotechnology, vol. 164, 2011, pp. 338-352.
Chen, M., Hu, M., Hofestädt, R.: A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes. Applied Biochemistry and Biotechnology. 164, 338-352 (2011).
Chen, Ming, Hu, Minjie, and Hofestädt, Ralf. “A Systematic Petri Net Approach for Multiple-Scale Modeling and Simulation of Biochemical Processes”. Applied Biochemistry and Biotechnology 164.3 (2011): 338-352.
This data publication is cited in the following publications:
This publication cites the following data publications:

38 References

Data provided by Europe PubMed Central.


ML, 1992

AUTHOR UNKNOWN, 0

JC, Journal of Chemical Technology & Biotechnology 61(), 1994
Quantitative Petri net model of gene regulated metabolic networks in the cell.
Chen M, Hofestadt R., In Silico Biol. (Gedrukt) 3(3), 2003
PMID: 12954095

K, PAT 2(4), 2005

G, International Journal of Production Research 31(10), 1993

R, Lecture Notes in Computer Science 674(), 1993

TDC, IEEE Journal on Selected Areas in Communications 8(3), 1990

SK, Tibtech 11(), 1993

JS, Computers & Chemical Engineering 30(10), 2006

SA, Biophotonics International 13(), 2002
Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum.
van den Berg MA, Albang R, Albermann K, Badger JH, Daran JM, Driessen AJ, Garcia-Estrada C, Fedorova ND, Harris DM, Heijne WH, Joardar V, Kiel JA, Kovalchuk A, Martin JF, Nierman WC, Nijland JG, Pronk JT, Roubos JA, van der Klei IJ, van Peij NN, Veenhuis M, von Dohren H, Wagner C, Wortman J, Bovenberg RA., Nat. Biotechnol. 26(10), 2008
PMID: 18820685
A multi-scale study of industrial fermentation processes and their optimization.
Zhang S, Chu J, Zhuang Y., Adv. Biochem. Eng. Biotechnol. 87(), 2004
PMID: 15217105

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 21136204
PubMed | Europe PMC

Search this title in

Google Scholar