A sorting system with automated gates permits individual operant experiments with mice from a social home cage

Winter Y, Schaefers ATU (2011)
Journal of Neuroscience Methods 196(2): 276-280.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
;
Abstract / Bemerkung
Behavioral experiments based on operant procedures can be time-consuming for small amounts of data. While individual testing and handling of animals can influence attention, emotion, and behavior, and interfere with experimental outcome, many operant protocols require individual testing. We developed an RFID-technology- and transponder-based sorting system that allows removing the human factor for longer-term experiments. Identity detectors and automated gates route mice individually from their social home cage to an adjacent operant compartment with 24/7 operation. CD1-mice learnt quickly to individually pass through the sorting system. At no time did more than a single mouse enter the operant compartment. After 3 days of adjusting to the sorting system, groups of 4 mice completed about 50 experimental trials per day in the operant compartment without experimenter intervention. The automated sorting system eliminates handling, isolation, and disturbance of the animals, eliminates experimenter-induced variability, saves experimenter time, and is financially economical. It makes possible a new approach for high-throughput experimentation, and is a viable tool for increasing quality and efficiency of many behavioral and neurobiological investigations. It can connect a social home cage, through individual sorting automation, to diverse setups including classical operant chambers, mazes, or arenas with video-based behavior classification. Such highly automated systems will permit efficient high-throughput screening even for transgenic animals with only subtle neurological or psychiatric symptoms where elaborate or longer-term protocols are required for behavioral diagnosis. (C) 2011 Elsevier BM. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
Journal of Neuroscience Methods
Band
196
Zeitschriftennummer
2
Seite
276-280
ISSN
PUB-ID

Zitieren

Winter Y, Schaefers ATU. A sorting system with automated gates permits individual operant experiments with mice from a social home cage. Journal of Neuroscience Methods. 2011;196(2):276-280.
Winter, Y., & Schaefers, A. T. U. (2011). A sorting system with automated gates permits individual operant experiments with mice from a social home cage. Journal of Neuroscience Methods, 196(2), 276-280. doi:10.1016/j.jneumeth.2011.01.017
Winter, Y., and Schaefers, A. T. U. (2011). A sorting system with automated gates permits individual operant experiments with mice from a social home cage. Journal of Neuroscience Methods 196, 276-280.
Winter, Y., & Schaefers, A.T.U., 2011. A sorting system with automated gates permits individual operant experiments with mice from a social home cage. Journal of Neuroscience Methods, 196(2), p 276-280.
Y. Winter and A.T.U. Schaefers, “A sorting system with automated gates permits individual operant experiments with mice from a social home cage”, Journal of Neuroscience Methods, vol. 196, 2011, pp. 276-280.
Winter, Y., Schaefers, A.T.U.: A sorting system with automated gates permits individual operant experiments with mice from a social home cage. Journal of Neuroscience Methods. 196, 276-280 (2011).
Winter, York, and Schaefers, Andrea T. U. “A sorting system with automated gates permits individual operant experiments with mice from a social home cage”. Journal of Neuroscience Methods 196.2 (2011): 276-280.

9 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools.
Bains RS, Wells S, Sillito RR, Armstrong JD, Cater HL, Banks G, Nolan PM., J Neurosci Methods 300(), 2018
PMID: 28456660
An Automated, Experimenter-Free Method for the Standardised, Operant Cognitive Testing of Rats.
Rivalan M, Munawar H, Fuchs A, Winter Y., PLoS One 12(1), 2017
PMID: 28060883
Spatial cognition in a virtual reality home-cage extension for freely moving rodents.
Kaupert U, Thurley K, Frei K, Bagorda F, Schatz A, Tocker G, Rapoport S, Derdikman D, Winter Y., J Neurophysiol 117(4), 2017
PMID: 28077665
Structured evaluation of rodent behavioral tests used in drug discovery research.
Hånell A, Marklund N., Front Behav Neurosci 8(), 2014
PMID: 25100962
Big behavioral data: psychology, ethology and the foundations of neuroscience.
Gomez-Marin A, Paton JJ, Kampff AR, Costa RM, Mainen ZF., Nat Neurosci 17(11), 2014
PMID: 25349912
The surveillance state of behavioral automation.
Schaefer AT, Claridge-Chang A., Curr Opin Neurobiol 22(1), 2012
PMID: 22119142

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 21256865
PubMed | Europe PMC

Suchen in

Google Scholar