Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface

Regtmeier J, Käsewieter J, Everwand M, Anselmetti D (2011)
Journal of Separation Science 34(10): 1180-1183.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Continuous-flow separation of nanoparticles (NPs) (15 and 39 nm) is demonstrated based on electrostatic sieving at a micro-nanofluidic interface. The interface is realized in a poly(dimethylsiloxane) device with a nanoslit of 525 nm laterally spanning the microfluidic channel (aspect ratio of 540:1). Within this nanoslit, the Debye layers overlap and generate an electrostatic sieve. This was exploited to selectively deflect and sort NPs with a sorting purity of up to 97%. Because of the continuous-flow operation, the sample is continuously fed into the device, immediately separated, and the parameters can be adapted in real time. For bioanalytical purposes, we also demonstrate the deflection of proteins (longest axis 6.8 nm). The continuous operation mode and the general applicability of this separation concept make this method a valuable addition to the current Lab-on-a-Chip devices for continuous sorting of NPs and macromolecules.
Erscheinungsjahr
Zeitschriftentitel
Journal of Separation Science
Band
34
Zeitschriftennummer
10
Seite
1180-1183
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PUB-ID

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Regtmeier J, Käsewieter J, Everwand M, Anselmetti D. Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface. Journal of Separation Science. 2011;34(10):1180-1183.
Regtmeier, J., Käsewieter, J., Everwand, M., & Anselmetti, D. (2011). Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface. Journal of Separation Science, 34(10), 1180-1183. doi:10.1002/jssc.201100007
Regtmeier, J., Käsewieter, J., Everwand, M., and Anselmetti, D. (2011). Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface. Journal of Separation Science 34, 1180-1183.
Regtmeier, J., et al., 2011. Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface. Journal of Separation Science, 34(10), p 1180-1183.
J. Regtmeier, et al., “Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface”, Journal of Separation Science, vol. 34, 2011, pp. 1180-1183.
Regtmeier, J., Käsewieter, J., Everwand, M., Anselmetti, D.: Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface. Journal of Separation Science. 34, 1180-1183 (2011).
Regtmeier, Jan, Käsewieter, Jörg, Everwand, Martina, and Anselmetti, Dario. “Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface”. Journal of Separation Science 34.10 (2011): 1180-1183.

3 Zitationen in Europe PMC

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