A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation

Sammet B, Brax M, Sewald N (2011)
Beilstein Journal of Organic Chemistry 7: 243-245.

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A novel highly enantioselective two step access to a unit B precursor of cryptophycins in good yields from commercially available starting materials has been developed. The key step is an asymmetric hydrogenation using the commercially available [(COD)Rh-(R,R)-Et-DuPhos]BF4 catalyst. The synthetic route provides the advantage of less synthetic steps, proceeds with high yields and enantioselectivity, and avoids hazardous reaction conditions.
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Sammet B, Brax M, Sewald N. A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation. Beilstein Journal of Organic Chemistry. 2011;7:243-245.
Sammet, B., Brax, M., & Sewald, N. (2011). A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation. Beilstein Journal of Organic Chemistry, 7, 243-245.
Sammet, B., Brax, M., and Sewald, N. (2011). A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation. Beilstein Journal of Organic Chemistry 7, 243-245.
Sammet, B., Brax, M., & Sewald, N., 2011. A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation. Beilstein Journal of Organic Chemistry, 7, p 243-245.
B. Sammet, M. Brax, and N. Sewald, “A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation”, Beilstein Journal of Organic Chemistry, vol. 7, 2011, pp. 243-245.
Sammet, B., Brax, M., Sewald, N.: A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation. Beilstein Journal of Organic Chemistry. 7, 243-245 (2011).
Sammet, Benedikt, Brax, Mathilde, and Sewald, Norbert. “A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation”. Beilstein Journal of Organic Chemistry 7 (2011): 243-245.
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2 Citations in Europe PMC

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Recent approaches for the synthesis of modified cryptophycins.
Weiss C, Sammet B, Sewald N., Nat Prod Rep 30(7), 2013
PMID: 23732943
Total synthesis and biological evaluation of fluorinated cryptophycins.
Weiß C, Bogner T, Sammet B, Sewald N., Beilstein J Org Chem 8(), 2012
PMID: 23209540

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