Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens

Traub WH, Kleber I, Pühler A, Burkardt HJ (1976)
Chemotherapy 22(5): 297-312.

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Abstract
A multiple drug-resistant strain of Serratia marcescens (bacteriocin type 18) was isolated from three clinical patients. The isolates were found to carry a conjugally nontransferable, nonmobilizeable resistance plasmid (R-plasmid) with resistance-(r)-determinants against ten antimicrobial drugs: ampicillin, carbenicillin, chloramphenicol, gentamicin, kanamycin, neomycin, streptomycin, tobramycin, triple sulfonamides, cotrimoxazole, and--possibly--nalidixic acid, as determined with exposure to 'curing' agents (ethidium bromide, acridine orange, and sodium dodecyl sulfate) and by the high rate of spontaneous loss of r-determinants. Dyebuoyant density centrifugation allowed recovery of R-plasmid DNA that measured roughly 24 mum in contour length; after 'curing' with concomitant loss of 9 r-determinants, the contour length of the R-plasmid DNA of one isolate (No. SE 154) had decreased to roughly 15 mum, and none was detected in the sole variant of the isolate that spontaneously had lost 11 r-determinants.
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Traub WH, Kleber I, Pühler A, Burkardt HJ. Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens. Chemotherapy. 1976;22(5):297-312.
Traub, W. H., Kleber, I., Pühler, A., & Burkardt, H. J. (1976). Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens. Chemotherapy, 22(5), 297-312.
Traub, W. H., Kleber, I., Pühler, A., and Burkardt, H. J. (1976). Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens. Chemotherapy 22, 297-312.
Traub, W.H., et al., 1976. Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens. Chemotherapy, 22(5), p 297-312.
W.H. Traub, et al., “Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens”, Chemotherapy, vol. 22, 1976, pp. 297-312.
Traub, W.H., Kleber, I., Pühler, A., Burkardt, H.J.: Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens. Chemotherapy. 22, 297-312 (1976).
Traub, W. H., Kleber, I., Pühler, Alfred, and Burkardt, H. J. “Characterization of a nosocomially significant, multiple drug-resistant strain of Serratia marcescens”. Chemotherapy 22.5 (1976): 297-312.
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PMID: 181215
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