Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study

Labudda K, Brand M, Mertens M, Ollech I, Markowitsch HJ, Woermann FG (2010)
Behavioural Neurology 23(3): 131-143.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ;
Abstract
We aimed to study whether previously described impairment in decision making under risky conditions in patients with Parkinson's disease (PD) is affected by deficits in using information about potential incentives or by processing feedback (in terms of fictitious gains and losses following each decision). Additionally, we studied whether the neural correlates of using explicit information in decision making under risk differ between PD patients and healthy subjects. We investigated ten cognitively intact PD patients and twelve healthy subjects with the Game of Dice Task (GDT) to assess risky decision making, and with an fMRI paradigm to analyse the neural correlates of information integration in the deliberative decision phase. Behaviourally, PD patients showed selective impairment in the GDT but not on the fMRI task that did not include a feedback component. Healthy subjects exhibited lateral prefrontal, anterior cingulate and parietal activations when integrating decision-relevant information. Despite similar behavioural patterns on the fMRI task, patients exhibited reduced parietal activation. Behavioural results suggest that PD patients' deficits in risky decision making are dominated by impaired feedback utilization not compensable by intact cognitive functions. Our fmRI results suggest similarities but also differences in neural correlates when using explicit information for the decision process, potentially indicating different strategy application even if the interfering feedback component is excluded.
Publishing Year
ISSN
PUB-ID

Cite this

Labudda K, Brand M, Mertens M, Ollech I, Markowitsch HJ, Woermann FG. Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study. Behavioural Neurology. 2010;23(3):131-143.
Labudda, K., Brand, M., Mertens, M., Ollech, I., Markowitsch, H. J., & Woermann, F. G. (2010). Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study. Behavioural Neurology, 23(3), 131-143. doi:10.3233/BEN-2010-0277
Labudda, K., Brand, M., Mertens, M., Ollech, I., Markowitsch, H. J., and Woermann, F. G. (2010). Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study. Behavioural Neurology 23, 131-143.
Labudda, K., et al., 2010. Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study. Behavioural Neurology, 23(3), p 131-143.
K. Labudda, et al., “Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study”, Behavioural Neurology, vol. 23, 2010, pp. 131-143.
Labudda, K., Brand, M., Mertens, M., Ollech, I., Markowitsch, H.J., Woermann, F.G.: Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study. Behavioural Neurology. 23, 131-143 (2010).
Labudda, Kirsten, Brand, Matthias, Mertens, Markus, Ollech, Isabelle, Markowitsch, Hans J., and Woermann, Friedrich G. “Decision making under risk condition in patients with Parkinson's disease: A behavioural and fMRI study”. Behavioural Neurology 23.3 (2010): 131-143.
This data publication is cited in the following publications:
This publication cites the following data publications:

15 Citations in Europe PMC

Data provided by Europe PubMed Central.

Chronic D2/3 agonist ropinirole treatment increases preference for uncertainty in rats regardless of baseline choice patterns.
Tremblay M, Silveira MM, Kaur S, Hosking JG, Adams WK, Baunez C, Winstanley CA., Eur J Neurosci 45(1), 2017
PMID: 27422144
The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson's Disease.
Abrevaya S, Sedeño L, Fitipaldi S, Pineda D, Lopera F, Buritica O, Villegas A, Bustamante C, Gomez D, Trujillo N, Pautassi R, Ibáñez A, García AM., J Alzheimers Dis 55(4), 2017
PMID: 27834777
Sex and HIV serostatus differences in decision making under risk among substance-dependent individuals.
Martin E, Gonzalez R, Vassileva J, Maki PM, Bechara A, Brand M., J Clin Exp Neuropsychol 38(4), 2016
PMID: 26882176
Reduced risk avoidance and altered neural correlates of feedback processing in patients with borderline personality disorder.
Endrass T, Schuermann B, Roepke S, Kessler-Scheil S, Kathmann N., Psychiatry Res 243(), 2016
PMID: 27344588
Theory of mind and decision-making processes are impaired in Parkinson's disease.
Xi C, Zhu Y, Mu Y, Chen B, Dong B, Cheng H, Hu P, Zhu C, Wang K., Behav Brain Res 279(), 2015
PMID: 25435317
Betting on DBS: Effects of subthalamic nucleus deep brain stimulation on risk taking and decision making in patients with Parkinson's disease.
Brandt J, Rogerson M, Al-Joudi H, Reckess G, Shpritz B, Umeh CC, Aljehani N, Mills K, Mari Z., Neuropsychology 29(4), 2015
PMID: 25486385
Trust behavior in Parkinson's disease: results of a trust game experiment.
Javor A, Riedl R, Kirchmayr M, Reichenberger M, Ransmayr G., BMC Neurol 15(), 2015
PMID: 26227627
Similarities and Differences in Decision-Making Impairments between Autism Spectrum Disorder and Schizophrenia.
Zhang L, Tang J, Dong Y, Ji Y, Tao R, Liang Z, Chen J, Wu Y, Wang K., Front Behav Neurosci 9(), 2015
PMID: 26441583
Stress and decision making: neural correlates of the interaction between stress, executive functions, and decision making under risk.
Gathmann B, Schulte FP, Maderwald S, Pawlikowski M, Starcke K, Schäfer LC, Schöler T, Wolf OT, Brand M., Exp Brain Res 232(3), 2014
PMID: 24408441
Decision making among HIV+ drug using men who have sex with men: a preliminary report from the Chicago Multicenter AIDS Cohort Study.
Martin EM, DeHaan S, Vassileva J, Gonzalez R, Weller J, Bechara A., J Clin Exp Neuropsychol 35(6), 2013
PMID: 23701366
Affective disorders in Parkinson's disease.
Aminian KS, Strafella AP., Curr Opin Neurol 26(4), 2013
PMID: 23757262
Stress effects on framed decisions: there are differences for gains and losses.
Pabst S, Brand M, Wolf OT., Front Behav Neurosci 7(), 2013
PMID: 24130523
Neural reward processing under dopamine agonists: imaging.
Kassubek J, Abler B, Pinkhardt EH., J Neurol Sci 310(1-2), 2011
PMID: 21762926

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 21098967
PubMed | Europe PMC

Search this title in

Google Scholar