Intron creation and DNA repair

Ragg H (2011)
Cell. Mol. Life Sci. 68(2): 235-242.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
The genesis of the exon-intron patterns of eukaryotic genes persists as one of the most enigmatic questions in molecular genetics. In particular, the origin and mechanisms responsible for creation of spliceosomal introns have remained controversial. Now the issue appears to have taken a turn. The formation of novel introns in eukaryotes, including some vertebrate lineages, is not as rare as commonly assumed. Moreover, introns appear to have been gained in parallel at closely spaced sites and even repeatedly at the same position. Based on these discoveries, novel hypotheses of intron creation have been developed. The new concepts posit that DNA repair processes are a major source of intron formation. Here, after summarizing the current views of intron gain mechanisms, I review findings in support of the DNA repair hypothesis that provides a global mechanistic scenario for intron creation. Some implications on our perception of the mosaic structure of eukaryotic genes are also discussed.
Cell. Mol. Life Sci.


Ragg H. Intron creation and DNA repair. Cell. Mol. Life Sci. 2011;68(2):235-242.
Ragg, H. (2011). Intron creation and DNA repair. Cell. Mol. Life Sci., 68(2), 235-242. doi:10.1007/s00018-010-0532-2
Ragg, H. (2011). Intron creation and DNA repair. Cell. Mol. Life Sci. 68, 235-242.
Ragg, H., 2011. Intron creation and DNA repair. Cell. Mol. Life Sci., 68(2), p 235-242.
H. Ragg, “Intron creation and DNA repair”, Cell. Mol. Life Sci., vol. 68, 2011, pp. 235-242.
Ragg, H.: Intron creation and DNA repair. Cell. Mol. Life Sci. 68, 235-242 (2011).
Ragg, Hermann. “Intron creation and DNA repair”. Cell. Mol. Life Sci. 68.2 (2011): 235-242.

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Hsp27 gene in Drosophila ananassae subgroup was split by a recently acquired intron.
Zhang L, Kang H, Jin S, Zeng QT, Yang Y., J Genet 95(2), 2016
PMID: 27350667
Gene make-up: rapid and massive intron gains after horizontal transfer of a bacterial α-amylase gene to Basidiomycetes.
Da Lage JL, Binder M, Hua-Van A, Janeček S, Casane D., BMC Evol Biol 13(), 2013
PMID: 23405862
Spliceosome twin introns in fungal nuclear transcripts.
Flipphi M, Fekete E, Ag N, Scazzocchio C, Karaffa L., Fungal Genet Biol 57(), 2013
PMID: 23792080
The role of reverse transcriptase in intron gain and loss mechanisms.
Cohen NE, Shen R, Carmel L., Mol Biol Evol 29(1), 2012
PMID: 21804076
Mechanisms of intron gain and loss in Drosophila.
Yenerall P, Krupa B, Zhou L., BMC Evol Biol 11(), 2011
PMID: 22182367

83 References

Daten bereitgestellt von Europe PubMed Central.

Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ.
Andrade P, Martin MJ, Juarez R, Lopez de Saro F, Blanco L., Proc. Natl. Acad. Sci. U.S.A. 106(38), 2009
PMID: 19805281
Eukaryotic DNA polymerases: proposal for a revised nomenclature.
Burgers PM, Koonin EV, Bruford E, Blanco L, Burtis KC, Christman MF, Copeland WC, Friedberg EC, Hanaoka F, Hinkle DC, Lawrence CW, Nakanishi M, Ohmori H, Prakash L, Prakash S, Reynaud CA, Sugino A, Todo T, Wang Z, Weill JC, Woodgate R., J. Biol. Chem. 276(47), 2001
PMID: 11579108

Comprehensive splice-site analysis using comparative genomics.
Sheth N, Roca X, Hastings ML, Roeder T, Krainer AR, Sachidanandam R., Nucleic Acids Res. 34(14), 2006
PMID: 16914448
Evolutionary dynamics of U12-type spliceosomal introns.
Lin CF, Mount SM, Jarmolowski A, Makalowski W., BMC Evol. Biol. 10(), 2010
PMID: 20163699
The meaning of nonsense.
Stalder L, Muhlemann O., Trends Cell Biol. 18(7), 2008
PMID: 18524595
Where do introns come from?
Catania F, Lynch M., PLoS Biol. 6(11), 2008
PMID: 19067485


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