Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

Hoy B, Loewer M, Weydig C, Carra G, Tegtmeyer N, Geppert T, Schroeder P, Sewald N, Backert S, Schneider G, Wessler S (2010)
EMBO REPORTS 11(10): 798-804.

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Abstract
Mammalian and prokaryotic high-temperature requirement A (HtrA) proteins are chaperones and serine proteases with important roles in protein quality control. Here, we describe an entirely new function of HtrA and identify it as a new secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of the cell-adhesion protein E-cadherin. E-cadherin shedding disrupts epithelial barrier functions allowing H. pylori designed to access the intercellular space. We then designed a small-molecule inhibitor that efficiently blocks HtrA activity, E-cadherin cleavage and intercellular entry of H. pylori.
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Hoy B, Loewer M, Weydig C, et al. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS. 2010;11(10):798-804.
Hoy, B., Loewer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schroeder, P., et al. (2010). Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS, 11(10), 798-804.
Hoy, B., Loewer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schroeder, P., Sewald, N., Backert, S., Schneider, G., et al. (2010). Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS 11, 798-804.
Hoy, B., et al., 2010. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS, 11(10), p 798-804.
B. Hoy, et al., “Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion”, EMBO REPORTS, vol. 11, 2010, pp. 798-804.
Hoy, B., Loewer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schroeder, P., Sewald, N., Backert, S., Schneider, G., Wessler, S.: Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS. 11, 798-804 (2010).
Hoy, Benjamin, Loewer, Martin, Weydig, Christiane, Carra, Gert, Tegtmeyer, Nicole, Geppert, Tim, Schroeder, Peter, Sewald, Norbert, Backert, Steffen, Schneider, Gisbert, and Wessler, Silja. “Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion”. EMBO REPORTS 11.10 (2010): 798-804.
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