A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans

de Quervain DJ, Kolassa I-T, Ertl V, Onyut PL, Neuner F, Elbert T, Papassotiropoulos A (2007)
Nature Neuroscience 10(9): 1137-1139.

Download
No fulltext has been uploaded. References only!
Journal Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ;
Abstract
Emotionally arousing events are recalled better than neutral events. This phenomenon, which helps us to remember important and potentially vital information, depends on the activation of noradrenergic transmission in the brain. Here we show that a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor, is related to enhanced emotional memory in healthy Swiss subjects and in survivors of the Rwandan civil war who experienced highly aversive emotional situations.
Publishing Year
ISSN
PUB-ID

Cite this

de Quervain DJ, Kolassa I-T, Ertl V, et al. A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience. 2007;10(9):1137-1139.
de Quervain, D. J., Kolassa, I. - T., Ertl, V., Onyut, P. L., Neuner, F., Elbert, T., & Papassotiropoulos, A. (2007). A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience, 10(9), 1137-1139. doi:10.1038/nn1945
de Quervain, D. J., Kolassa, I. - T., Ertl, V., Onyut, P. L., Neuner, F., Elbert, T., and Papassotiropoulos, A. (2007). A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience 10, 1137-1139.
de Quervain, D.J., et al., 2007. A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience, 10(9), p 1137-1139.
D.J. de Quervain, et al., “A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans”, Nature Neuroscience, vol. 10, 2007, pp. 1137-1139.
de Quervain, D.J., Kolassa, I.-T., Ertl, V., Onyut, P.L., Neuner, F., Elbert, T., Papassotiropoulos, A.: A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience. 10, 1137-1139 (2007).
de Quervain, D. J., Kolassa, Iris-Tatjana, Ertl, Verena, Onyut, P. L., Neuner, Frank, Elbert, Thomas, and Papassotiropoulos, A. “A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans”. Nature Neuroscience 10.9 (2007): 1137-1139.
This data publication is cited in the following publications:
This publication cites the following data publications:

70 Citations in Europe PMC

Data provided by Europe PubMed Central.

Memory dynamics under stress.
Quaedflieg CWEM, Schwabe L., Memory 26(3), 2018
PMID: 28625108
Meta-analysis of the interaction between serotonin transporter promoter variant, stress, and posttraumatic stress disorder.
Zhao M, Yang J, Wang W, Ma J, Zhang J, Zhao X, Qiu X, Yang X, Qiao Z, Song X, Wang L, Jiang S, Zhao E, Yang Y., Sci Rep 7(1), 2017
PMID: 29184054
The individual contribution of DSM 5 symptom clusters of PTSD, life events, and childhood adversity to frontal oscillatory brain asymmetry in a large sample of active combatants.
Moran JK, Crombach A, Elbert T, Nandi C, Bambonye M, Wienbruch C, Lommen U, Weierstall R., Biol Psychol 129(), 2017
PMID: 28958482
The ADRA2B gene in the production of false memories for affective information in healthy female volunteers.
Fairfield B, Mammarella N, Di Domenico A, D'Aurora M, Stuppia L, Gatta V., Behav. Brain Res. 333(), 2017
PMID: 28697904
Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory consolidation in rats: Consequences for the development of post-traumatic stress disorder.
Morena M, Berardi A, Peloso A, Valeri D, Palmery M, Trezza V, Schelling G, Campolongo P., Behav. Brain Res. 329(), 2017
PMID: 28461010
ADRA2B deletion variant influences time-dependent effects of pre-learning stress on long-term memory.
Zoladz PR, Dailey AM, Nagle HE, Fiely MK, Mosley BE, Brown CM, Duffy TJ, Scharf AR, Earley MB, Rorabaugh BR., Neurobiol Learn Mem 140(), 2017
PMID: 28254464
Function of brain α2B-adrenergic receptor characterized with subtype-selective α2B antagonist and KO mice.
Luhrs L, Manlapaz C, Kedzie K, Rao S, Cabrera-Ghayouri S, Donello J, Gil D., Neuroscience 339(), 2016
PMID: 27751959
Computational dissection of human episodic memory reveals mental process-specific genetic profiles.
Luksys G, Fastenrath M, Coynel D, Freytag V, Gschwind L, Heck A, Jessen F, Maier W, Milnik A, Riedel-Heller SG, Scherer M, Spalek K, Vogler C, Wagner M, Wolfsgruber S, Papassotiropoulos A, de Quervain DJ., Proc. Natl. Acad. Sci. U.S.A. 112(35), 2015
PMID: 26261317
A 9-nucleotide Ins/Del in ADRA2B modulates orientation of attention to facial expressions and emotional words.
Shoumin X, Pingyuan G, She L, Kunpeng D, Haijun H, Peizhe Z, Fuchang Z., Behav Pharmacol 25(8), 2014
PMID: 25325286
BAIAP2 is related to emotional modulation of human memory strength.
Luksys G, Ackermann S, Coynel D, Fastenrath M, Gschwind L, Heck A, Rasch B, Spalek K, Vogler C, Papassotiropoulos A, de Quervain D., PLoS ONE 9(1), 2014
PMID: 24392092
Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience.
Strange BA, Gartmann N, Brenninkmeyer J, Haaker J, Reif A, Kalisch R, Buchel C., Neuroimage 84(), 2014
PMID: 24099848
The deletion variant of α2b-adrenergic receptor is associated with decreased risk in Alzheimer's disease and mild cognitive impairment.
Koutroumani M, Daniilidou M, Giannakouros T, Proitsi P, Liapi D, Germanou A, Nikolakaki E, Tsolaki M., J. Neurol. Sci. 328(1-2), 2013
PMID: 23499426
Haplotype polymorphism in the alpha-2B-adrenergic receptor gene influences response inhibition in a large Chinese sample.
Lei X, Chen C, He Q, Moyzis R, Xue G, Chen C, Cao Z, Li J, Li H, Zhu B, Zhang M, Li J, Dong Q., Neuropsychopharmacology 37(5), 2012
PMID: 22218095
Epistasis between 5-HTTLPR and ADRA2B polymorphisms influences attentional bias for emotional information in healthy volunteers.
Naudts KH, Azevedo RT, David AS, van Heeringen K, Gibbs AA., Int. J. Neuropsychopharmacol. 15(8), 2012
PMID: 21854681
Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory.
Heck A, Vogler C, Gschwind L, Ackermann S, Auschra B, Spalek K, Rasch B, de Quervain D, Papassotiropoulos A., PLoS ONE 6(12), 2011
PMID: 22216252
The neurogenetics of remembering emotions past.
Todd RM, Anderson AK., Proc. Natl. Acad. Sci. U.S.A. 106(45), 2009
PMID: 19889977
The benefit of forgetting suicidal ideation.
Goldney RD, Winefield AH, Winefield HR, Saebel J., Suicide Life Threat Behav 39(1), 2009
PMID: 19298148

14 References

Data provided by Europe PubMed Central.


AUTHOR UNKNOWN, 0
Mechanisms of emotional arousal and lasting declarative memory.
Cahill L, McGaugh JL., Trends Neurosci. 21(7), 1998
PMID: 9683321
Beta-adrenergic activation and memory for emotional events.
Cahill L, Prins B, Weber M, McGaugh JL., Nature 371(6499), 1994
PMID: 7935815
Beta-adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses.
Strange BA, Dolan RJ., Proc. Natl. Acad. Sci. U.S.A. 101(31), 2004
PMID: 15269349
Role of adrenal stress hormones in forming lasting memories in the brain.
McGaugh JL, Roozendaal B., Curr. Opin. Neurobiol. 12(2), 2002
PMID: 12015238
Stimulation of the noradrenergic system enhances and blockade reduces memory for emotional material in man.
O'Carroll RE, Drysdale E, Cahill L, Shajahan P, Ebmeier KP., Psychol Med 29(5), 1999
PMID: 10576300

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study.
Stein MB, Jang KL, Taylor S, Vernon PA, Livesley WJ., Am J Psychiatry 159(10), 2002
PMID: 12359672

Foa, Psychol. Assess. 9(), 1997
Pilot study of secondary prevention of posttraumatic stress disorder with propranolol.
Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP., Biol. Psychiatry 51(2), 2002
PMID: 11822998

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 17660814
PubMed | Europe PMC

Search this title in

Google Scholar