Altered oscillatory brain dynamics after repeated traumatic stress

Kolassa I-T, Wienbruch C, Neuner F, Schauer M, Ruf M, Odenwald M, Elbert T (2007)
BMC Psychiatry 7(1).

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Abstract
BACKGROUND: Repeated traumatic experiences, e.g. torture and war, lead to functional and structural cerebral changes, which should be detectable in cortical dynamics. Abnormal slow waves produced within circumscribed brain regions during a resting state have been associated with lesioned neural circuitry in neurological disorders and more recently also in mental illness. METHODS: Using magnetoencephalographic (MEG-based) source imaging, we mapped abnormal distributions of generators of slow waves in 97 survivors of torture and war with posttraumatic stress disorder (PTSD) in comparison to 97 controls. RESULTS: PTSD patients showed elevated production of focally generated slow waves (1-4 Hz), particularly in left temporal brain regions, with peak activities in the region of the insula. Furthermore, differential slow wave activity in right frontal areas was found in PTSD patients compared to controls. CONCLUSION: The insula, as a site of multimodal convergence, could play a key role in understanding the pathophysiology of PTSD, possibly accounting for what has been called posttraumatic alexithymia, i.e., reduced ability to identify, express and regulate emotional responses to reminders of traumatic events. Differences in activity in right frontal areas may indicate a dysfunctional PFC, which may lead to diminished extinction of conditioned fear and reduced inhibition of the amygdala.
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Kolassa I-T, Wienbruch C, Neuner F, et al. Altered oscillatory brain dynamics after repeated traumatic stress. BMC Psychiatry. 2007;7(1).
Kolassa, I. - T., Wienbruch, C., Neuner, F., Schauer, M., Ruf, M., Odenwald, M., & Elbert, T. (2007). Altered oscillatory brain dynamics after repeated traumatic stress. BMC Psychiatry, 7(1).
Kolassa, I. - T., Wienbruch, C., Neuner, F., Schauer, M., Ruf, M., Odenwald, M., and Elbert, T. (2007). Altered oscillatory brain dynamics after repeated traumatic stress. BMC Psychiatry 7.
Kolassa, I.-T., et al., 2007. Altered oscillatory brain dynamics after repeated traumatic stress. BMC Psychiatry, 7(1).
I.-T. Kolassa, et al., “Altered oscillatory brain dynamics after repeated traumatic stress”, BMC Psychiatry, vol. 7, 2007.
Kolassa, I.-T., Wienbruch, C., Neuner, F., Schauer, M., Ruf, M., Odenwald, M., Elbert, T.: Altered oscillatory brain dynamics after repeated traumatic stress. BMC Psychiatry. 7, (2007).
Kolassa, Iris-Tatjana, Wienbruch, Christian, Neuner, Frank, Schauer, Margarete, Ruf, Martina, Odenwald, Michael, and Elbert, Thomas. “Altered oscillatory brain dynamics after repeated traumatic stress”. BMC Psychiatry 7.1 (2007).
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16 Citations in Europe PMC

Data provided by Europe PubMed Central.

Threatening faces induce fear circuitry hypersynchrony in soldiers with post-traumatic stress disorder.
Dunkley BT, Pang EW, Sedge PA, Jetly R, Doesburg SM, Taylor MJ., Heliyon 2(1), 2016
PMID: 27441243
Male veterans with PTSD exhibit aberrant neural dynamics during working memory processing: an MEG study.
McDermott TJ, Badura-Brack AS, Becker KM, Ryan TJ, Khanna MM, Heinrichs-Graham E, Wilson TW., J Psychiatry Neurosci 41(4), 2016
PMID: 26645740
Oxytocin affects spontaneous neural oscillations in trauma-exposed war veterans.
Eidelman-Rothman M, Goldstein A, Levy J, Weisman O, Schneiderman I, Mankuta D, Zagoory-Sharon O, Feldman R., Front Behav Neurosci 9(), 2015
PMID: 26175673
Theta, mental flexibility, and post-traumatic stress disorder: connecting in the parietal cortex.
Dunkley BT, Sedge PA, Doesburg SM, Grodecki RJ, Jetly R, Shek PN, Taylor MJ, Pang EW., PLoS ONE 10(4), 2015
PMID: 25909654
[Magneto-encephalographic (MEG) brain recordings during traumatic memory recall in women with post-traumatic stress disorder: A pilot study].
Cottraux J, Lecaignard F, Yao SN, De Mey-Guillard C, Haour F, Delpuech C, Servan-Schreiber D., Encephale 41(3), 2015
PMID: 24793794
Resting-state hippocampal connectivity correlates with symptom severity in post-traumatic stress disorder.
Dunkley BT, Doesburg SM, Sedge PA, Grodecki RJ, Shek PN, Pang EW, Taylor MJ., Neuroimage Clin 5(), 2014
PMID: 25180157
Statistical Issues in TBI Clinical Studies.
Rapp PE, Cellucci CJ, Keyser DO, Gilpin AM, Darmon DM., Front Neurol 4(), 2013
PMID: 24312072
A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery: study protocol for a randomized controlled trial.
Hauer D, Kolassa IT, Laubender RP, Mansmann U, Hagl C, Roozendaal B, de Quervain DJ, Schelling G., Trials 14(), 2013
PMID: 23548162
Mild traumatic brain injury: longitudinal regional brain volume changes.
Zhou Y, Kierans A, Kenul D, Ge Y, Rath J, Reaume J, Grossman RI, Lui YW., Radiology 267(3), 2013
PMID: 23481161
Magnetic resonance volumetry and spectroscopy of hippocampus and insula in relation to severe exposure of traumatic stress.
Eckart C, Kaufmann J, Kanowski M, Tempelmann C, Hinrichs H, Elbert T, Heinze HJ, Kolassa IT., Psychophysiology 49(2), 2012
PMID: 22092224
Changes in cortical slow wave activity in healthy aging.
Leirer VM, Wienbruch C, Kolassa S, Schlee W, Elbert T, Kolassa IT., Brain Imaging Behav 5(3), 2011
PMID: 21698438
The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety.
Kim MJ, Loucks RA, Palmer AL, Brown AC, Solomon KM, Marchante AN, Whalen PJ., Behav. Brain Res. 223(2), 2011
PMID: 21536077
[Magnetoencephalography in psychiatry].
Mathiak K, Junghofer M, Pantev C, Rockstroh B., Nervenarzt 81(1), 2010
PMID: 20024527
Trauma-related impairment in children--a survey in Sri Lankan provinces affected by armed conflict.
Elbert T, Schauer M, Schauer E, Huschka B, Hirth M, Neuner F., Child Abuse Negl 33(4), 2009
PMID: 19324413

69 References

Data provided by Europe PubMed Central.

Computing contrasts, effect sizes, and counternulls on other people's published data: General procedures for research consumers
Rosnow RL, Rosenthal R., 1996
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress.
Wang J, Rao H, Wetmore GS, Furlan PM, Korczykowski M, Dinges DF, Detre JA., Proc. Natl. Acad. Sci. U.S.A. 102(49), 2005
PMID: 16306271
Circuitry and functional aspects of the insular lobe in primates including humans.
Augustine JR., Brain Res. Brain Res. Rev. 22(3), 1996
PMID: 8957561
The role of insula in language: an unsettled question
Ardila A., 1999
The insula of Reil in man and monkey. Architectonics, connectivity and function
Mesulam MM, Mufson EJ., 1985
Aphemia. Clinical-anatomic correlations.
Schiff HB, Alexander MP, Naeser MA, Galaburda AM., Arch. Neurol. 40(12), 1983
PMID: 6625983
Frontal lobes and language.
Alexander MP, Benson DF, Stuss DT., Brain Lang 37(4), 1989
PMID: 2479448
Mutism as a consequence of callosotomy.
Sussman NM, Gur RC, Gur RE, O'Connor MJ., J. Neurosurg. 59(3), 1983
PMID: 6886765
Speechlessness with occasional vocalization after bilateral opercular lesions: a case study
Cappa SF, Guidotti M, Papagno C, Vignolo LA., 1987
Lasting mutism associated with buccofacial apraxia
Pineda D, Ardila A., 1992
Functional lateralization of speech production at primary motor cortex: a fMRI study.
Wildgruber D, Ackermann H, Klose U, Kardatzki B, Grodd W., Neuroreport 7(15-17), 1996
PMID: 8981469
Opposite hemispheric lateralization effects during speaking and singing at motor cortex, insula and cerebellum.
Riecker A, Ackermann H, Wildgruber D, Dogil G, Grodd W., Neuroreport 11(9), 2000
PMID: 10884059
Gray matter density reduction in the insula in fire survivors with posttraumatic stress disorder: a voxel-based morphometric study.
Chen S, Xia W, Li L, Liu J, He Z, Zhang Z, Yan L, Zhang J, Hu D., Psychiatry Res 146(1), 2006
PMID: 16371250
The nature of traumatic memories: a 4-T FMRI functional connectivity analysis.
Lanius RA, Williamson PC, Densmore M, Boksman K, Neufeld RW, Gati JS, Menon RS., Am J Psychiatry 161(1), 2004
PMID: 14702248
Alexithymia in PTSD: psychometric and FMRI studies.
Frewen PA, Pain C, Dozois DJ, Lanius RA., Ann. N. Y. Acad. Sci. 1071(), 2006
PMID: 16891585
A positron emission tomographic study of symptom provocation in PTSD.
Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK., Ann. N. Y. Acad. Sci. 821(), 1997
PMID: 9238243
Darwin and the neural bases of emotion and affective style.
Davidson RJ., Ann. N. Y. Acad. Sci. 1000(), 2003
PMID: 14766646

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