Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.

Damme M, Morelle W, Schmidt B, Andersson C, Fogh J, Michalski J-C, Lübke T (2010)
Molecular and Cellular Biology 30(1): 273-283.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Alpha-mannosidosis is caused by the genetic defect of the lysosomal alpha-d-mannosidase (LAMAN), which is involved in the breakdown of free alpha-linked mannose-containing oligosaccharides originating from glycoproteins with N-linked glycans, and thus manifests itself in an extensive storage of mannose-containing oligosaccharides. Here we demonstrate in a model of mice with alpha-mannosidosis that native lysosomal proteins exhibit elongated N-linked oligosaccharides as shown by two-dimensional difference gel electrophoresis, deglycosylation assays, and mass spectrometry. The analysis of cathepsin B-derived oligosaccharides revealed a hypermannosylation of glycoproteins in mice with alpha-mannosidosis as indicated by the predominance of extended Man3GlcNAc2 oligosaccharides. Treatment with recombinant human alpha-mannosidase partially corrected the hyperglycosylation of lysosomal proteins in vivo and in vitro. These data clearly demonstrate that LAMAN is involved not only in the lysosomal catabolism of free oligosaccharides but also in the trimming of asparagine-linked oligosaccharides on native lysosomal proteins.
Erscheinungsjahr
Zeitschriftentitel
Molecular and Cellular Biology
Band
30
Zeitschriftennummer
1
Seite
273-283
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Damme M, Morelle W, Schmidt B, et al. Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis. Molecular and Cellular Biology. 2010;30(1):273-283.
Damme, M., Morelle, W., Schmidt, B., Andersson, C., Fogh, J., Michalski, J. - C., & Lübke, T. (2010). Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis. Molecular and Cellular Biology, 30(1), 273-283. doi:10.1128/MCB.01143-09
Damme, M., Morelle, W., Schmidt, B., Andersson, C., Fogh, J., Michalski, J. - C., and Lübke, T. (2010). Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis. Molecular and Cellular Biology 30, 273-283.
Damme, M., et al., 2010. Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis. Molecular and Cellular Biology, 30(1), p 273-283.
M. Damme, et al., “Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.”, Molecular and Cellular Biology, vol. 30, 2010, pp. 273-283.
Damme, M., Morelle, W., Schmidt, B., Andersson, C., Fogh, J., Michalski, J.-C., Lübke, T.: Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis. Molecular and Cellular Biology. 30, 273-283 (2010).
Damme, Markus, Morelle, Willy, Schmidt, Bernhard, Andersson, Claes, Fogh, Jens, Michalski, Jean-Claude, and Lübke, Torben. “Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.”. Molecular and Cellular Biology 30.1 (2010): 273-283.

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61 References

Daten bereitgestellt von Europe PubMed Central.

Structural studies on the carbohydrate moieties of rat liver cathepsins B and H.
Taniguchi T, Mizuochi T, Towatari T, Katunuma N, Kobata A., J. Biochem. 97(3), 1985
PMID: 4019443
Lysosomal cysteine proteases: facts and opportunities.
Turk V, Turk B, Turk D., EMBO J. 20(17), 2001
PMID: 11532926
Function of oligosaccharide modification in glucocerebrosidase, a membrane-associated lysosomal hydrolase.
Van Weely S, Aerts JM, Van Leeuwen MB, Heikoop JC, Donker-Koopman WE, Barranger JA, Tager JM, Schram AW., Eur. J. Biochem. 191(3), 1990
PMID: 2143986
Alterations in neuron morphology in feline mannosidosis. A Golgi study.
Walkley SU, Blakemore WF, Purpura DP., Acta Neuropathol. 53(1), 1981
PMID: 7211201
Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage disease.
Walkley SU, Thrall MA, Dobrenis K, Huang M, March PA, Siegel DA, Wurzelmann S., Proc. Natl. Acad. Sci. U.S.A. 91(8), 1994
PMID: 8159689
Secondary lipid accumulation in lysosomal disease.
Walkley SU, Vanier MT., Biochim. Biophys. Acta 1793(4), 2009
PMID: 19111580
[Effect of the injection of Triton WR 1339 on the hepatic lysosomes of the rat.]
WATTIAUX R, WIBO M, BAUDHUIN P., Arch. Int. Physiol. Biochim. 71(), 1963
PMID: 13999241
Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation.
Willenborg M, Schmidt CK, Braun P, Landgrebe J, von Figura K, Saftig P, Eskelinen EL., J. Lipid Res. 46(12), 2005
PMID: 16177447
Nucleolin: acharan sulfate-binding protein on the surface of cancer cells.
Joo EJ, ten Dam GB, van Kuppevelt TH, Toida T, Linhardt RJ, Kim YS., Glycobiology 15(1), 2005
PMID: 15329357

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