Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox

Godl K, Hallmann A, Wenzl S, Sumper M (1997)
EMBO J. 16: 25-34.

Journal Article | Published | English

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Abstract
The alga Volvox carteri represents one of the simplest multicellular organisms. Its extracellular matrix (ECM) is modified under developmental control, e.g. under the influence of the sex-inducing pheromone that triggers development of males and females at a concentration below 10(-16) M. A novel ECM glycoprotein (pherophorin-S) synthesized in response to this pheromone was identified and characterized. Although being a typical member of the pherophorins, which are identified by a C-terminal domain with sequence homology to the sex-inducing pheromone, pherophorin-S exhibits a completely novel set of properties. In contrast to the other members of the family, which are found as part of the insoluble ECM structures of the cellular zone, pherophorin-S is targeted to the cell-free interior of the spherical organism and remains in a soluble state. A main structural difference is the presence of a polyhydroxyproline spacer in pherophorin-S that is linked to a saccharide containing a phosphodiester bridge between two arabinose residues. Sequence comparisons indicate that the self-assembling proteins that create the main parts of the complex Volvox ECM have evolved from a common ancestral gene.
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Godl K, Hallmann A, Wenzl S, Sumper M. Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox. EMBO J. 16. 1997:25-34.
Godl, K., Hallmann, A., Wenzl, S., & Sumper, M. (1997). Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox. EMBO J. 16, 25-34.
Godl, K., Hallmann, A., Wenzl, S., and Sumper, M. (1997). Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox. EMBO J. 16, 25-34.
Godl, K., et al., 1997. Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox. EMBO J. 16, , p 25-34.
K. Godl, et al., “Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox”, EMBO J. 16, 1997, pp. 25-34.
Godl, K., Hallmann, A., Wenzl, S., Sumper, M.: Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox. EMBO J. 16. 25-34 (1997).
Godl, K., Hallmann, Armin, Wenzl, S., and Sumper, M. “Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox”. EMBO J. 16 (1997): 25-34.
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