Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis

Jin H, Cominelli E, Bailey P, Parr A, Mehrtens F, Jones J, Tonelli C, Weisshaar B, Martin C (2000)
The EMBO Journal 19(22): 6150-6161.

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An Arabidopsis thaliana line that is mutant for the R2R3 MYB gene, AtMYB4, shows enhanced levels of sinapate esters in its leaves. The mutant line is more tolerant of UV-B irradiation than wild type. The increase in sinapate ester accumulation in the mutant is associated with an enhanced expression of the gene encoding cinnamate 4-hydroxylase, which appears to be the principal target of AtMYB4 and an effective rate limiting step in the synthesis of sinapate ester sunscreens. AtMYB4 expression is downregulated by exposure to UV-B light, indicating that derepression is an important mechanism for acclimation to UV-B in A.thaliana. The response of target genes to AtMYB4 repression is dose dependent, a feature that operates under physiological conditions to reinforce the silencing effect of AtMYB4 at high activity. AtMYB4 works as a repressor of target gene expression and includes a repression domain. It belongs to a novel group of plant R2R3 MYB proteins involved in transcriptional silencing. The balance between MYB activators and repressors on common target promoters may provide extra flexibility in transcriptional control.
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Jin H, Cominelli E, Bailey P, et al. Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. The EMBO Journal. 2000;19(22):6150-6161.
Jin, H., Cominelli, E., Bailey, P., Parr, A., Mehrtens, F., Jones, J., Tonelli, C., et al. (2000). Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. The EMBO Journal, 19(22), 6150-6161. doi:10.1093/emboj/19.22.6150
Jin, H., Cominelli, E., Bailey, P., Parr, A., Mehrtens, F., Jones, J., Tonelli, C., Weisshaar, B., and Martin, C. (2000). Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. The EMBO Journal 19, 6150-6161.
Jin, H., et al., 2000. Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. The EMBO Journal, 19(22), p 6150-6161.
H. Jin, et al., “Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis”, The EMBO Journal, vol. 19, 2000, pp. 6150-6161.
Jin, H., Cominelli, E., Bailey, P., Parr, A., Mehrtens, F., Jones, J., Tonelli, C., Weisshaar, B., Martin, C.: Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. The EMBO Journal. 19, 6150-6161 (2000).
Jin, H., Cominelli, E., Bailey, P., Parr, A., Mehrtens, Frank, Jones, J., Tonelli, C., Weisshaar, Bernd, and Martin, Cathie. “Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis”. The EMBO Journal 19.22 (2000): 6150-6161.
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