Regulated nuclear targeting of cauliflower mosaic virus

Karsies A, Merkle T, Szurek B, Bonas U, Hohn T, Leclerc D (2002)
Journal of General Virology 83(7): 1783-1790.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The mature cauliflower mosaic virus (CaMV) capsid protein (CP), if expressed in the absence of other viral proteins, is transported into the plant cell nucleus by the action of a nuclear localization signal (NLS) close to the N terminus. In contrast, virus particles do not enter the nucleus, but dock at the nuclear membrane, a process inhibited by anti-NLS antibodies or by GTP gamma S, and apparently mediated by interaction of CP with host importin alpha. The very acidic N-terminal extension of the viral CP precursor inhibits nuclear targeting of the protein and hence the precursor is localized in the cytoplasm. We hypothesize that this provides a control mechanism which ensures that the CP precursor is used for virus assembly in the cytoplasm and that only mature virus particles reach the nuclear pore.
Erscheinungsjahr
Zeitschriftentitel
Journal of General Virology
Band
83
Zeitschriftennummer
7
Seite
1783-1790
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Karsies A, Merkle T, Szurek B, Bonas U, Hohn T, Leclerc D. Regulated nuclear targeting of cauliflower mosaic virus. Journal of General Virology. 2002;83(7):1783-1790.
Karsies, A., Merkle, T., Szurek, B., Bonas, U., Hohn, T., & Leclerc, D. (2002). Regulated nuclear targeting of cauliflower mosaic virus. Journal of General Virology, 83(7), 1783-1790. doi:10.1099/0022-1317-83-7-1783
Karsies, A., Merkle, T., Szurek, B., Bonas, U., Hohn, T., and Leclerc, D. (2002). Regulated nuclear targeting of cauliflower mosaic virus. Journal of General Virology 83, 1783-1790.
Karsies, A., et al., 2002. Regulated nuclear targeting of cauliflower mosaic virus. Journal of General Virology, 83(7), p 1783-1790.
A. Karsies, et al., “Regulated nuclear targeting of cauliflower mosaic virus”, Journal of General Virology, vol. 83, 2002, pp. 1783-1790.
Karsies, A., Merkle, T., Szurek, B., Bonas, U., Hohn, T., Leclerc, D.: Regulated nuclear targeting of cauliflower mosaic virus. Journal of General Virology. 83, 1783-1790 (2002).
Karsies, A., Merkle, Thomas, Szurek, B., Bonas, U., Hohn, T., and Leclerc, D. “Regulated nuclear targeting of cauliflower mosaic virus”. Journal of General Virology 83.7 (2002): 1783-1790.

10 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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