Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997)
Proc. Natl. Acad. Sci. USA 94(6): 2642-2647.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ;
Erscheinungsjahr
Zeitschriftentitel
Proc. Natl. Acad. Sci. USA
Band
94
Zeitschriftennummer
6
Seite
2642-2647
ISSN
PUB-ID

Zitieren

Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA. 1997;94(6):2642-2647.
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997). Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA, 94(6), 2642-2647.
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., and Kaltschmidt, C. (1997). Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 2642-2647.
Kaltschmidt, B., et al., 1997. Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA, 94(6), p 2642-2647.
B. Kaltschmidt, et al., “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”, Proc. Natl. Acad. Sci. USA, vol. 94, 1997, pp. 2642-2647.
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P.A., Kaltschmidt, C.: Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94, 2642-2647 (1997).
Kaltschmidt, Barbara, Uherek, M., Volk, B., Baeuerle, P.A., and Kaltschmidt, Christian. “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”. Proc. Natl. Acad. Sci. USA 94.6 (1997): 2642-2647.

325 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi.
Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T., Brain Pathol 28(1), 2018
PMID: 27997051
Regulation of Survival Motor Neuron Protein by the Nuclear Factor-Kappa B Pathway in Mouse Spinal Cord Motoneurons.
Arumugam S, Mincheva-Tasheva S, Periyakaruppiah A, de la Fuente S, Soler RM, Garcera A., Mol Neurobiol 55(6), 2018
PMID: 28808928
Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes.
Weinberg RP, Koledova VV, Shin H, Park JH, Tan YA, Sinskey AJ, Sambanthamurthi R, Rha C., Int J Alzheimers Dis 2018(), 2018
PMID: 29666700
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.
Skaper SD, Facci L, Zusso M, Giusti P., Front Cell Neurosci 12(), 2018
PMID: 29618972
Deciphering the Astrocyte Reaction in Alzheimer's Disease.
Perez-Nievas BG, Serrano-Pozo A., Front Aging Neurosci 10(), 2018
PMID: 29922147
Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway.
Gu SM, Lee HP, Ham YW, Son DJ, Kim HY, Oh KW, Han SB, Yun J, Hong JT., Neuromolecular Med 20(3), 2018
PMID: 29802525
S100B immunization triggers NFκB and complement activation in an autoimmune glaucoma model.
Reinehr S, Reinhard J, Gandej M, Gottschalk I, Stute G, Faissner A, Dick HB, Joachim SC., Sci Rep 8(1), 2018
PMID: 29959432
Astrocytic NF-κB brings the best and worst out of microglia.
Dokalis N, Prinz M., EMBO J 37(16), 2018
PMID: 30037825
Inflammation as a central mechanism in Alzheimer's disease.
Kinney JW, Bemiller SM, Murtishaw AS, Leisgang AM, Salazar AM, Lamb BT., Alzheimers Dement (N Y) 4(), 2018
PMID: 30406177
NF-κB p65 directs sex-specific neuroprotection in human neurons.
Ruiz-Perera LM, Schneider L, Windmöller BA, Müller J, Greiner JFW, Kaltschmidt C, Kaltschmidt B., Sci Rep 8(1), 2018
PMID: 30375448
Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons.
Narne P, Pandey V, Simhadri PK, Phanithi PB., Semin Cell Dev Biol 63(), 2017
PMID: 27867042
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
Fielder E, von Zglinicki T, Jurk D., J Alzheimers Dis 60(s1), 2017
PMID: 28436392
Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs.
Chung MM, Nicol CJ, Cheng YC, Lin KH, Chen YL, Pei D, Lin CH, Shih YN, Yen CH, Chen SJ, Huang RN, Chiang MC., Exp Cell Res 352(1), 2017
PMID: 28159472
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease.
Franco R, Martínez-Pinilla E, Navarro G, Zamarbide M., Prog Neurobiol 149-150(), 2017
PMID: 28189739
Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer's Disease Brain.
Thangavel R, Kempuraj D, Zaheer S, Raikwar S, Ahmed ME, Selvakumar GP, Iyer SS, Zaheer A., Front Aging Neurosci 9(), 2017
PMID: 28572767
Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease.
Nho K, Kim S, Horgusluoglu E, Risacher SL, Shen L, Kim D, Lee S, Foroud T, Shaw LM, Trojanowski JQ, Aisen PS, Petersen RC, Jack CR, Weiner MW, Green RC, Toga AW, Saykin AJ, Alzheimer’s Disease Neuroimaging Initiative (ADNI)., BMC Med Genomics 10(suppl 1), 2017
PMID: 28589856
Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences.
Zhang Y, Moreno-Villanueva M, Krieger S, Ramesh GT, Neelam S, Wu H., Int J Mol Sci 18(6), 2017
PMID: 28561779
Reactive Astrocytes: Production, Function, and Therapeutic Potential.
Liddelow SA, Barres BA., Immunity 46(6), 2017
PMID: 28636962
Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer's disease.
Djordjevic J, Thomson E, Chowdhury SR, Snow WM, Perez C, Wong TP, Fernyhough P, Albensi BC., Neuroscience 361(), 2017
PMID: 28802916
Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury.
Theus MH, Brickler T, Meza AL, Coutermarsh-Ott S, Hazy A, Gris D, Allen IC., J Immunol 199(10), 2017
PMID: 28993512
Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer's Disease Mouse Model.
Palomino-Alonso M, Lachén-Montes M, González-Morales A, Ausín K, Pérez-Mediavilla A, Fernández-Irigoyen J, Santamaría E., Int J Mol Sci 18(11), 2017
PMID: 29077059
Epigenetic Regulatory Mechanisms Induced by Resveratrol.
Fernandes GFS, Silva GDB, Pavan AR, Chiba DE, Chin CM, Dos Santos JL., Nutrients 9(11), 2017
PMID: 29104258
PPARδ agonist GW0742 ameliorates Aβ1-42-induced hippocampal neurotoxicity in mice.
An YQ, Zhang CT, Du Y, Zhang M, Tang SS, Hu M, Long Y, Sun HB, Hong H., Metab Brain Dis 31(3), 2016
PMID: 26864581
Inhibition of the neuronal NFκB pathway attenuates bortezomib-induced neuropathy in a mouse model.
Alé A, Bruna J, Calls A, Karamita M, Haralambous S, Probert L, Navarro X, Udina E., Neurotoxicology 55(), 2016
PMID: 27211850
c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa.
Wang T, Shi W, Fan T, Wan X, Chen YH, Ruan Q., Immunol Invest 45(8), 2016
PMID: 27224262
Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier.
Griffin JM, Kho D, Graham ES, Nicholson LF, O'Carroll SJ., PLoS One 11(6), 2016
PMID: 27309956
Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease.
Snow WM, Albensi BC., Front Mol Neurosci 9(), 2016
PMID: 27881951
LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways.
Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G., J Neuroinflammation 13(1), 2016
PMID: 27931217
Valproic acid alleviates memory deficits and attenuates amyloid-β deposition in transgenic mouse model of Alzheimer's disease.
Xuan AG, Pan XB, Wei P, Ji WD, Zhang WJ, Liu JH, Hong LP, Chen WL, Long DH., Mol Neurobiol 51(1), 2015
PMID: 24854198
Alzheimer's disease and type 2 diabetes via chronic inflammatory mechanisms.
Mushtaq G, Khan JA, Kumosani TA, Kamal MA., Saudi J Biol Sci 22(1), 2015
PMID: 25561876
Whole-food diet worsened cognitive dysfunction in an Alzheimer's disease mouse model.
Parrott MD, Winocur G, Bazinet RP, Ma DW, Greenwood CE., Neurobiol Aging 36(1), 2015
PMID: 25212462
Alcohol exposure after mild focal traumatic brain injury impairs neurological recovery and exacerbates localized neuroinflammation.
Teng SX, Katz PS, Maxi JK, Mayeux JP, Gilpin NW, Molina PE., Brain Behav Immun 45(), 2015
PMID: 25489880
NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease.
Lian H, Yang L, Cole A, Sun L, Chiang AC, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, Zheng H., Neuron 85(1), 2015
PMID: 25533482
Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells.
Wilkins HM, Carl SM, Weber SG, Ramanujan SA, Festoff BW, Linseman DA, Swerdlow RH., J Alzheimers Dis 45(1), 2015
PMID: 25537010
PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.
Martire S, Mosca L, d'Erme M., Mech Ageing Dev 146-148(), 2015
PMID: 25881554
NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases.
Lanzillotta A, Porrini V, Bellucci A, Benarese M, Branca C, Parrella E, Spano PF, Pizzi M., Front Neurol 6(), 2015
PMID: 26042083
Paradoxical role of PKA inhibitor on amyloidβ-induced memory deficit.
Amini E, Nassireslami E, Payandemehr B, Khodagholi F, Foolad F, Khalaj S, Hamedani MP, Azimi L, Sharifzadeh M., Physiol Behav 149(), 2015
PMID: 26037462
Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.
Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, Vincent B, Govitrapong P., J Pineal Res 59(3), 2015
PMID: 26123100
Elusive roles for reactive astrocytes in neurodegenerative diseases.
Ben Haim L, Carrillo-de Sauvage MA, Ceyzériat K, Escartin C., Front Cell Neurosci 9(), 2015
PMID: 26283915
Magnesium Lithospermate B Protects Neurons Against Amyloid β (1-42)-Induced Neurotoxicity Through the NF-κB Pathway.
Jiang F, Mao Y, Liu H, Xu P, Zhang L, Qian X, Sun X., Neurochem Res 40(9), 2015
PMID: 26285901
Beyond the 5-HT3 receptors: A role for α7nACh receptors in neuroprotective aspects of tropisetron.
Khalifeh S, Fakhfouri G, Mehr SE, Mousavizadeh K, Dehpour AR, Khodagholi F, Kazmi S, Rahimian R., Hum Exp Toxicol 34(9), 2015
PMID: 26286524
Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells.
Yshii LM, Denadai-Souza A, Vasconcelos AR, Avellar MC, Scavone C., J Neuroinflammation 12(), 2015
PMID: 26502720
NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain.
Kaltschmidt B, Kaltschmidt C., Front Mol Neurosci 8(), 2015
PMID: 26635522
Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins.
Kopitar-Jerala N., Front Mol Neurosci 8(), 2015
PMID: 26696821
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review.
Shih RH, Wang CY, Yang CM., Front Mol Neurosci 8(), 2015
PMID: 26733801
Protein damage, repair and proteolysis.
Chondrogianni N, Petropoulos I, Grimm S, Georgila K, Catalgol B, Friguet B, Grune T, Gonos ES., Mol Aspects Med 35(), 2014
PMID: 23107776
Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo.
Tang SS, Hong H, Chen L, Mei ZL, Ji MJ, Xiang GQ, Li N, Ji H., Neurobiol Aging 35(3), 2014
PMID: 24269024
SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients.
Facchinetti P, Dorard E, Contremoulins V, Gaillard MC, Déglon N, Sazdovitch V, Guihenneuc-Jouyaux C, Brouillet E, Duyckaerts C, Allinquant B., Neurobiol Aging 35(5), 2014
PMID: 24262202
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit.
Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T., Neurobiol Dis 64(), 2014
PMID: 24345324
Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain.
Solberg NO, Chamberlin R, Vigil JR, Deck LM, Heidrich JE, Brown DC, Brady CI, Vander Jagt TA, Garwood M, Bisoffi M, Severns V, Vander Jagt DL, Sillerud LO., J Alzheimers Dis 40(1), 2014
PMID: 24413613
HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.
Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ., Brain 137(pt 3), 2014
PMID: 24459107
Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic memory deficits.
Ohta Y, Tremblay C, Schneider JA, Bennett DA, Calon F, Julien JP., Acta Neuropathol Commun 2(), 2014
PMID: 24690380
Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway.
Marwarha G, Raza S, Meiers C, Ghribi O., Biochim Biophys Acta 1842(9), 2014
PMID: 24874077
Interleukin-1 signaling pathway as a therapeutic target in transthyretin amyloidosis.
Gonçalves NP, Vieira P, Saraiva MJ., Amyloid 21(3), 2014
PMID: 24918964
Oridonin attenuates Aβ1-42-induced neuroinflammation and inhibits NF-κB pathway.
Wang S, Yang H, Yu L, Jin J, Qian L, Zhao H, Xu Y, Zhu X., PLoS One 9(8), 2014
PMID: 25121593
Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.
Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU., Nat Commun 5(), 2014
PMID: 25190485
Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats.
Fu X, Zhang J, Guo L, Xu Y, Sun L, Wang S, Feng Y, Gou L, Zhang L, Liu Y., Pharmacol Biochem Behav 126(), 2014
PMID: 25220684
Quetiapine attenuates glial activation and proinflammatory cytokines in APP/PS1 transgenic mice via inhibition of nuclear factor-κB pathway.
Zhu S, Shi R, Li V, Wang J, Zhang R, Tempier A, He J, Kong J, Wang JF, Li XM., Int J Neuropsychopharmacol 18(3), 2014
PMID: 25618401
NF-κB signaling pathways: role in nervous system physiology and pathology.
Mincheva-Tasheva S, Soler RM., Neuroscientist 19(2), 2013
PMID: 22785105
Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony.
Medeiros R, LaFerla FM., Exp Neurol 239(), 2013
PMID: 23063604
Mechanisms of islet amyloidosis toxicity in type 2 diabetes.
Abedini A, Schmidt AM., FEBS Lett 587(8), 2013
PMID: 23337872
Peripheral inflammation in neurodegeneration.
Träger U, Tabrizi SJ., J Mol Med (Berl) 91(6), 2013
PMID: 23546523
Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Weiner MW, Baldwin CT, Lunetta K, Farrer LA, Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, AddNeuroMed Consortium, McDonald BC, Farlow MR, Ghetti B, Indiana Memory and Aging Study, Huentelman MJ, Saykin AJ, Alzheimer's Disease Neuroimaging Initiative (ADNI)., Mol Psychiatry 18(7), 2013
PMID: 23608917
Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease.
Wang CY, Xie JW, Xu Y, Wang T, Cai JH, Wang X, Zhao BL, An L, Wang ZY., Antioxid Redox Signal 19(17), 2013
PMID: 23541064
Selective inhibition of PCAF suppresses microglial-mediated β-amyloid neurotoxicity.
Park SY, Lee YH, Seong AR, Lee J, Jun W, Yoon HG., Int J Mol Med 32(2), 2013
PMID: 23740527
Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model.
Fan H, Guo Y, Liang X, Yuan Y, Qi X, Wang M, Ma J, Zhou H., J Biomed Res 27(4), 2013
PMID: 23885269
Gemfibrozil pretreatment proved protection against acute restraint stress-induced changes in the male rats' hippocampus.
Khalaj L, Nejad SC, Mohammadi M, Zadeh SS, Pour MH, Ahmadiani A, Khodagholi F, Ashabi G, Alamdary SZ, Samami E., Brain Res 1527(), 2013
PMID: 23850768
Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats.
Rahimian R, Fakhfouri G, Ejtemaei Mehr S, Ghia JE, Genazzani AA, Payandemehr B, Dehpour AR, Mousavizadeh K, Lim D., Eur J Clin Invest 43(10), 2013
PMID: 23937291
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.
Chen CH, Zhou W, Liu S, Deng Y, Cai F, Tone M, Tone Y, Tong Y, Song W., Int J Neuropsychopharmacol 15(1), 2012
PMID: 21329555
Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway.
Huang X, Chen Y, Zhang H, Ma Q, Zhang YW, Xu H., Neurobiol Aging 33(5), 2012
PMID: 22056200
Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease.
Sun X, Bromley-Brits K, Song W., J Neurochem 120 Suppl 1(), 2012
PMID: 22122349
Why are hippocampal CA1 neurons vulnerable but motor cortex neurons resistant to transient ischemia?
Zhu H, Yoshimoto T, Imajo-Ohmi S, Dazortsava M, Mathivanan A, Yamashima T., J Neurochem 120(4), 2012
PMID: 22017466
Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.
Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello AC., J Neuroinflammation 9(), 2012
PMID: 22472085
Neuronal NF-κB ablation does not influence neuro-axonal degeneration in experimental autoimmune demyelination.
Lee DH, Kubera K, Rosenthal B, Kaltschmidt B, Kaltschmidt C, Gold R, Linker RA., J Neuroimmunol 246(1-2), 2012
PMID: 22475633
WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway.
Fakhfouri G, Ahmadiani A, Rahimian R, Grolla AA, Moradi F, Haeri A., Neuropharmacology 63(4), 2012
PMID: 22634229
Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.
Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F., J Biol Chem 287(29), 2012
PMID: 22654105
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice.
Baiguera C, Alghisi M, Pinna A, Bellucci A, De Luca MA, Frau L, Morelli M, Ingrassia R, Benarese M, Porrini V, Pellitteri M, Bertini G, Fabene PF, Sigala S, Spillantini MG, Liou HC, Spano PF, Pizzi M., Brain 135(pt 9), 2012
PMID: 22915735
Transcriptional and post-transcriptional regulation of β-secretase.
Tamagno E, Guglielmotto M, Monteleone D, Vercelli A, Tabaton M., IUBMB Life 64(12), 2012
PMID: 23180460
Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity.
Chan KH, Lam KS, Cheng OY, Kwan JS, Ho PW, Cheng KK, Chung SK, Ho JW, Guo VY, Xu A., PLoS One 7(12), 2012
PMID: 23300647
Effects of Fructus mume Extract on MAPK and NF-κB Signaling and the Resultant Improvement in the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion.
Jeon WK, Ma J, Choi BR, Han SH, Jin Q, Hwang BY, Han JS., Evid Based Complement Alternat Med 2012(), 2012
PMID: 23346201
APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.
Combarros O, Rodríguez-Rodríguez E, Mateo I, Vázquez-Higuera JL, Infante J, Berciano J, Sánchez-Juan P., Neurobiol Aging 32(3), 2011
PMID: 19660836
Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system.
Yakovleva T, Bazov I, Watanabe H, Hauser KF, Bakalkin G., Brain Behav Immun 25 Suppl 1(), 2011
PMID: 21195164
Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease.
Nijholt DA, de Graaf TR, van Haastert ES, Oliveira AO, Berkers CR, Zwart R, Ovaa H, Baas F, Hoozemans JJ, Scheper W., Cell Death Differ 18(6), 2011
PMID: 21252911
Tetrandrine suppresses amyloid-β-induced inflammatory cytokines by inhibiting NF-κB pathway in murine BV2 microglial cells.
He FQ, Qiu BY, Li TK, Xie Q, Cui DJ, Huang XL, Gan HT., Int Immunopharmacol 11(9), 2011
PMID: 21496499
Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.
Nakamura-Yanagidaira T, Takahashi Y, Sano K, Murata T, Hayashi T., Mol Vis 17(), 2011
PMID: 21850191
Characterisation of amyloid-induced inflammatory responses in the rat retina.
Howlett DR, Bate ST, Collier S, Lawman A, Chapman T, Ashmeade T, Marshall I, Anderson PJ, Philpott KL, Richardson JC, Hille CJ., Exp Brain Res 214(2), 2011
PMID: 21850448
Formation and signaling actions of electrophilic lipids.
Schopfer FJ, Cipollina C, Freeman BA., Chem Rev 111(10), 2011
PMID: 21928855
Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation.
Kim MJ, Seong AR, Yoo JY, Jin CH, Lee YH, Kim YJ, Lee J, Jun WJ, Yoon HG., Mol Nutr Food Res 55(12), 2011
PMID: 22038937
NF-kappaB signaling in neurite growth and neuronal survival.
Teng FY, Tang BL., Rev Neurosci 21(4), 2010
PMID: 21086762
The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.
Muirhead KE, Borger E, Aitken L, Conway SJ, Gunn-Moore FJ., Biochem J 426(3), 2010
PMID: 20175748
TAp63 is a transcriptional target of NF-kappaB.
Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX., J Cell Biochem 109(4), 2010
PMID: 20052674
Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity.
Ho JW, Ho PW, Zhang WY, Liu HF, Kwok KH, Yiu DC, Chan KH, Kung MH, Ramsden DB, Ho SL., Free Radic Biol Med 49(2), 2010
PMID: 20385226
Control of transferrin expression by β-amyloid through the CP2 transcription factor.
Jang SM, Kim JW, Kim CH, An JH, Kang EJ, Kim CG, Kim HJ, Choi KH., FEBS J 277(19), 2010
PMID: 20796026
The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.
Dasari B, Prasanthi JR, Marwarha G, Singh BB, Ghribi O., BMC Ophthalmol 10(), 2010
PMID: 20836858
Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.
Lu J, Wu DM, Zheng YL, Hu B, Zhang ZF, Shan Q, Zheng ZH, Liu CM, Wang YJ., J Pathol 222(2), 2010
PMID: 20690163
Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation.
Liberge M, Manrique C, Bernard-Demanze L, Lacour M., J Neuroinflammation 7(), 2010
PMID: 21143912
Mechanisms of neurodegeneration and regeneration in alcoholism.
Crews FT, Nixon K., Alcohol Alcohol 44(2), 2009
PMID: 18940959
Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability.
Pizzi M, Sarnico I, Lanzillotta A, Battistin L, Spano P., FEBS J 276(1), 2009
PMID: 19087197
Gene-gene interaction between CARD8 and interleukin-6 reduces Alzheimer's disease risk.
Fontalba A, Gutiérrez O, Llorca J, Mateo I, Vázquez-Higuera JL, Berciano J, Fernández-Luna JL, Combarros O., J Neurol 256(7), 2009
PMID: 19252766
Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice.
Zhang X, Luhrs KJ, Ryff KA, Malik WT, Driscoll MJ, Culver B., Neuroscience 161(1), 2009
PMID: 19286451
Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity.
Chaïb-Oukadour I, Gil C, Rodríguez-Alvarez J, Ortega A, Aguilera J., Mol Cell Neurosci 41(3), 2009
PMID: 19344769
Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice.
Echeverria V, Burgess S, Gamble-George J, Zeitlin R, Lin X, Cao C, Arendash GW., Neuroscience 162(4), 2009
PMID: 19447162
Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling.
Pan XD, Chen XC, Zhu YG, Chen LM, Zhang J, Huang TW, Ye QY, Huang HP., Glia 57(11), 2009
PMID: 19170180
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.
Barrachina M, Ferrer I., J Neuropathol Exp Neurol 68(8), 2009
PMID: 19606065
NF-kappaB in the nervous system.
Kaltschmidt B, Kaltschmidt C., Cold Spring Harb Perspect Biol 1(3), 2009
PMID: 20066105
Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation.
Philippe O, Rio M, Carioux A, Plaza JM, Guigue P, Molinari F, Boddaert N, Bole-Feysot C, Nitschke P, Smahi A, Munnich A, Colleaux L., Am J Hum Genet 85(6), 2009
PMID: 20004764
Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier.
Politi C, Del Turco D, Sie JM, Golinski PA, Tegeder I, Deller T, Schultz C., Neuropathol Appl Neurobiol 34(3), 2008
PMID: 17986183
Pharmacological enhancement of neuronal survival.
Calabrese EJ., Crit Rev Toxicol 38(4), 2008
PMID: 18432420
NF-kappaB signaling pathway and its therapeutic implications in human diseases.
Sarkar FH, Li Y, Wang Z, Kong D., Int Rev Immunol 27(5), 2008
PMID: 18853341
Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes.
Sarnico I, Boroni F, Benarese M, Alghisi M, Valerio A, Battistin L, Spano P, Pizzi M., J Neural Transm (Vienna) 115(5), 2008
PMID: 18197358
Amyloid beta-peptide activates nuclear factor-kappaB through an N-methyl-D-aspartate signaling pathway in cultured cerebellar cells.
Kawamoto EM, Lepsch LB, Boaventura MF, Munhoz CD, Lima LS, Yshii LM, Avellar MC, Curi R, Mattson MP, Scavone C., J Neurosci Res 86(4), 2008
PMID: 17969100
Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture.
Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, Hong JS., Neurochem Res 33(10), 2008
PMID: 18368483
Flavanols, mild cognitive impairment, and Alzheimer's dementia.
Patel AK, Rogers JT, Huang X., Int J Clin Exp Med 1(2), 2008
PMID: 19079672
p75(NTR) activation of NF-kappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells.
Bai Y, Li Q, Yang J, Zhou X, Yin X, Zhao D., Neurosci Res 62(1), 2008
PMID: 18602709
Activation of nuclear factor-kappaB during retinal degeneration in rd mice.
Zeng HY, Tso MO, Lai S, Lai H., Mol Vis 14(), 2008
PMID: 18552981
Raf inhibition protects cortical cells against beta-amyloid toxicity.
Echeverria V, Burgess S, Gamble-George J, Arendash GW, Citron BA., Neurosci Lett 444(1), 2008
PMID: 18706973
Inhibition of Abeta production by NF-kappaB inhibitors.
Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M., Neurosci Lett 415(1), 2007
PMID: 17223266
Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus.
Müller GJ, Lassmann H, Johansen FF., Neurobiol Dis 25(3), 2007
PMID: 17207631
NF-kappa B as a therapeutic target in neurodegenerative diseases.
Camandola S, Mattson MP., Expert Opin Ther Targets 11(2), 2007
PMID: 17227229
CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway.
Ait-Ghezala G, Volmar CH, Frieling J, Paris D, Tweed M, Bakshi P, Mullan M., Eur J Neurosci 25(6), 2007
PMID: 17432959
Nuclear factor kappa-B p50 and p65 subunits expression in dementia with Lewy bodies.
Saldaña M, Mullol J, Aguilar E, Bonastre M, Marin C., Neuropathol Appl Neurobiol 33(3), 2007
PMID: 17442064
Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity.
Choi JJ, Choi J, Kang CD, Chen X, Wu CF, Ko KH, Kim WK., Free Radic Res 41(5), 2007
PMID: 17454138
Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicin.
Uberti D, Cenini G, Olivari L, Ferrari-Toninelli G, Porrello E, Cecchi C, Pensalfini A, Liguri G, Govoni S, Racchi M, Maurizio M., J Neurochem 103(1), 2007
PMID: 17608641
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.
Okvist A, Johansson S, Kuzmin A, Bazov I, Merino-Martinez R, Ponomarev I, Mayfield RD, Harris RA, Sheedy D, Garrick T, Harper C, Hurd YL, Terenius L, Ekström TJ, Bakalkin G, Yakovleva T., PLoS One 2(9), 2007
PMID: 17895971
Oxidative stress and transcriptional regulation in Alzheimer disease.
Shi Q, Gibson GE., Alzheimer Dis Assoc Disord 21(4), 2007
PMID: 18090434
Potential role of NF-kappaB in adult neural stem cells: the underrated steersman?
Widera D, Mikenberg I, Kaltschmidt B, Kaltschmidt C., Int J Dev Neurosci 24(2-3), 2006
PMID: 16413989
Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.
Tao Y, Yan D, Yang Q, Zeng R, Wang Y., Mol Cell Biol 26(3), 2006
PMID: 16428456
NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production.
Valerio A, Boroni F, Benarese M, Sarnico I, Ghisi V, Bresciani LG, Ferrario M, Borsani G, Spano P, Pizzi M., Eur J Neurosci 23(7), 2006
PMID: 16623827
Roles for NF-kappaB in nerve cell survival, plasticity, and disease.
Mattson MP, Meffert MK., Cell Death Differ 13(5), 2006
PMID: 16397579
Anti-inflammatory effect of jeongshintang through suppression of p38 activation in human astrocytoma, U373MG cells.
Kim SJ, Jeong HJ, Kim BK, Kim NH, Kim JS, Choi KS, Lee HJ, Kang ST, Shin SS, Kim WI, Eom HS, Lee KM, Um JY, Hong SH, Kim HM., Exp Mol Pathol 81(1), 2006
PMID: 16698013
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.
Rossner S, Sastre M, Bourne K, Lichtenthaler SF., Prog Neurobiol 79(2), 2006
PMID: 16904810
Pin1 in Alzheimer's disease.
Butterfield DA, Abdul HM, Opii W, Newman SF, Joshi G, Ansari MA, Sultana R., J Neurochem 98(6), 2006
PMID: 16945100
Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.
Schliebs R, Heidel K, Apelt J, Gniezdzinska M, Kirazov L, Szutowicz A., Brain Res 1122(1), 2006
PMID: 17026971
Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.
Widmer R, Ziaja I, Grune T., Free Radic Res 40(12), 2006
PMID: 17090415
NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain.
Huang Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX., Neurosci Lett 373(2), 2005
PMID: 15567564
Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients.
de las Cuevas N, Muñoz U, Hermida OG, Martín-Requero A., Neurobiol Aging 26(5), 2005
PMID: 15708436
NF-kappaB in the survival and plasticity of neurons.
Mattson MP., Neurochem Res 30(6-7), 2005
PMID: 16187223
NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity.
Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G, Dietz GP, Bähr M, Liou HC, Spano PF., Cell Death Differ 12(7), 2005
PMID: 15818410
Signaling via NF-kappaB in the nervous system.
Kaltschmidt B, Widera D, Kaltschmidt C., Biochim Biophys Acta 1745(3), 2005
PMID: 15993497
Selenium reduces the proapoptotic signaling associated to NF-kappaB pathway and stimulates glutathione peroxidase activity during excitotoxic damage produced by quinolinate in rat corpus striatum.
Santamaría A, Vázquez-Román B, La Cruz VP, González-Cortés C, Trejo-Solís MC, Galván-Arzate S, Jara-Prado A, Guevara-Fonseca J, Ali SF., Synapse 58(4), 2005
PMID: 16206188
Differential MnSOD and HO-1 expression in cerebral endothelial cells in response to sublethal oxidative stress.
Méthy D, Bertrand N, Prigent-Tessier A, Stanimirovic D, Beley A, Marie C., Brain Res 1003(1-2), 2004
PMID: 15019574
Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism.
Fernández-Tomé P, Brera B, Arévalo MA, de Ceballos ML., Neurobiol Dis 15(3), 2004
PMID: 15056466
Effect of cell density on intracellular levels of the Alzheimer's amyloid precursor protein.
Rebelo S, Henriques AG, da Cruz e Silva EF, da Cruz e Silva OA., J Neurosci Res 76(3), 2004
PMID: 15079870
N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.
Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Yodim M, Furukawa S, Nabeshima T, Naoi M., Neurochem Int 44(6), 2004
PMID: 14687604
GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M., J Biol Chem 279(44), 2004
PMID: 15322108
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS., EMBO J 23(20), 2004
PMID: 15457210
From calcium to NF-kappa B signaling pathways in neurons.
Lilienbaum A, Israël A., Mol Cell Biol 23(8), 2003
PMID: 12665571
Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy.
Campdelacreu J, Ezquerra M, Muñoz E, Oliva R, Tolosa E., Neurosci Lett 340(2), 2003
PMID: 12668260
Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.
Heneka MT, Gavrilyuk V, Landreth GE, O'Banion MK, Weinberg G, Feinstein DL., J Neurochem 85(2), 2003
PMID: 12675915
H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.
Tamagno E, Robino G, Obbili A, Bardini P, Aragno M, Parola M, Danni O., Exp Neurol 180(2), 2003
PMID: 12684028
Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.
Kim JY, Kim H, Lee SG, Choi BH, Kim YH, Huh PW, Lee KH, Han H, Rha HK., Biochem Biophys Res Commun 310(3), 2003
PMID: 14550290
Is DNA repair compromised in Alzheimer's disease?
Davydov V, Hansen LA, Shackelford DA., Neurobiol Aging 24(7), 2003
PMID: 12928056
MK-801 and 7-Ni attenuate the activation of brain NF-kappa B induced by LPS.
Glezer I, Munhoz CD, Kawamoto EM, Marcourakis T, Avellar MC, Avellar MC, Scavone C., Neuropharmacology 45(8), 2003
PMID: 14614955
Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells.
Kaltschmidt B, Heinrich M, Kaltschmidt C., Neuromolecular Med 2(3), 2002
PMID: 12622408
[The Rel/NF-kappa-B transcription factors: complex role in cell regulation].
Bottex-Gauthier C, Pollet S, Favier A, Vidal DR., Pathol Biol (Paris) 50(3), 2002
PMID: 11980335
Growing old with nuclear factor-kappaB.
Giardina C, Hubbard AK., Cell Stress Chaperones 7(2), 2002
PMID: 12380689
Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappaB activation.
Bisaglia M, Venezia V, Piccioli P, Stanzione S, Porcile C, Russo C, Mancini F, Milanese C, Schettini G., Neurochem Int 41(1), 2002
PMID: 11918971
Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid.
Tanaka S, Takehashi M, Matoh N, Iida S, Suzuki T, Futaki S, Hamada H, Masliah E, Sugiura Y, Ueda K., J Neurochem 82(2), 2002
PMID: 12124431
Nutritional approaches to combat oxidative stress in Alzheimer's disease.
Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V., J Nutr Biochem 13(8), 2002
PMID: 12165357
Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation.
Hilliard BA, Mason N, Xu L, Sun J, Lamhamedi-Cherradi SE, Liou HC, Hunter C, Chen YH., J Clin Invest 110(6), 2002
PMID: 12235116
NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line.
Gao F, Bales KR, Dodel RC, Liu J, Chen X, Hample H, Farlow MR, Paul SM, Du Y., Brain Res Mol Brain Res 105(1-2), 2002
PMID: 12399113
Hypoxia signaling to genes: significance in Alzheimer's disease.
Bazan NG, Palacios-Pelaez R, Lukiw WJ., Mol Neurobiol 26(2-3), 2002
PMID: 12428761
Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide.
Rogers J, Strohmeyer R, Kovelowski CJ, Li R., Glia 40(2), 2002
PMID: 12379913
Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases.
Casciati A, Ferri A, Cozzolino M, Celsi F, Nencini M, Rotilio G, Carrì MT., J Neurochem 83(5), 2002
PMID: 12437573
Cyclooxygenase-2 is a neuronal target gene of NF-kappaB.
Kaltschmidt B, Linker RA, Deng J, Kaltschmidt C., BMC Mol Biol 3(), 2002
PMID: 12466023
Neuroprotection from glutamate toxicity with ultra-low dose glutamate.
Jonas W, Lin Y, Tortella F., Neuroreport 12(2), 2001
PMID: 11209946
Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure.
Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF., Am J Pathol 158(2), 2001
PMID: 11159183
Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.
Rodrigues CM, Solá S, Brito MA, Brondino CD, Brites D, Moura JJ., Biochem Biophys Res Commun 281(2), 2001
PMID: 11181071
Intracellular pathways involved in TNF-alpha and superoxide anion release by Abeta(1-42)-stimulated primary human macrophages.
Smits HA, de Vos NM, Wat JW, van der Bruggen T, Verhoef J, Nottet HS., J Neuroimmunol 115(1-2), 2001
PMID: 11282164
Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease.
Teismann P, Schwaninger M, Weih F, Ferger B., Neuroreport 12(5), 2001
PMID: 11303744
Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity.
Calabrese V, Scapagnini G, Giuffrida Stella AM, Bates TE, Clark JB., Neurochem Res 26(6), 2001
PMID: 11519733
C-terminal fragment of amyloid precursor protein induces astrocytosis.
Bach JH, Chae HS, Rah JC, Lee MW, Park CH, Choi SH, Choi JK, Lee SH, Kim YS, Kim KY, Lee WB, Suh YH, Kim SS., J Neurochem 78(1), 2001
PMID: 11432978
Amyloid beta-peptide: biphasic dose responses.
Calabrese EJ., Crit Rev Toxicol 31(4-5), 2001
PMID: 11504184
From theory to therapy: implications from an in vitro model of ramified microglia.
Rosenstiel P, Lucius R, Deuschl G, Sievers J, Wilms H., Microsc Res Tech 54(1), 2001
PMID: 11526952
6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.
Blum D, Torch S, Nissou MF, Verna JM., Biochem Pharmacol 62(4), 2001
PMID: 11448458
The amyloid peptide induces early genotoxic damage in human preneuron NT2.
Santiard-Baron D, Lacoste A, Ellouk-Achard S, Soulié C, Nicole A, Sarasin A, Ceballos-Picot I., Mutat Res 479(1-2), 2001
PMID: 11470486
Enhanced expression of I-kappaB with neurofibrillary pathology in Alzheimer's disease.
Yoshiyama Y, Arai K, Hattori T., Neuroreport 12(12), 2001
PMID: 11522940
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease.
Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM., Prog Neurobiol 65(2), 2001
PMID: 11403877
S100beta induction of the proinflammatory cytokine interleukin-6 in neurons.
Li Y, Barger SW, Liu L, Mrak RE, Griffin WS., J Neurochem 74(1), 2000
PMID: 10617115
Model for aging in the basal forebrain cholinergic system.
Gu Z, Wortwein G, Yu J, Perez-Polo JR., Antioxid Redox Signal 2(3), 2000
PMID: 11229357
Roles of nuclear factor kappaB in neuronal survival and plasticity.
Mattson MP, Culmsee C, Yu Z, Camandola S., J Neurochem 74(2), 2000
PMID: 10646495
Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease.
Newman SJ, Bond B, Crook B, Darker J, Edge C, Maycox PR., Brain Res 857(1-2), 2000
PMID: 10700560
Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia.
Stephenson D, Yin T, Smalstig EB, Hsu MA, Panetta J, Little S, Clemens J., J Cereb Blood Flow Metab 20(3), 2000
PMID: 10724123
Cyanide-induced apoptosis involves oxidative-stress-activated NF-kappaB in cortical neurons.
Shou Y, Gunasekar PG, Borowitz JL, Isom GE., Toxicol Appl Pharmacol 164(2), 2000
PMID: 10764633
Anti-inflammatory drugs: a hope for Alzheimer's disease?
Hüll M, Lieb K, Fiebich BL., Expert Opin Investig Drugs 9(4), 2000
PMID: 11060701
The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type 2 expression, and macrophage/microglial activation in brain.
Heneka MT, Sharp A, Klockgether T, Gavrilyuk V, Feinstein DL., J Cereb Blood Flow Metab 20(5), 2000
PMID: 10826530
Inflammation and Alzheimer's disease.
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T., Neurobiol Aging 21(3), 2000
PMID: 10858586
The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus.
Kaltschmidt B, Kaltschmidt C, Hofmann TG, Hehner SP, Dröge W, Schmitz ML., Eur J Biochem 267(12), 2000
PMID: 10849002
beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress.
Brera B, Serrano A, de Ceballos ML., Neurobiol Dis 7(4), 2000
PMID: 10964610
The Rel/NF-kappa B family: friend and foe.
Perkins ND., Trends Biochem Sci 25(9), 2000
PMID: 10973057
Neuroinflammatory signaling upregulation in Alzheimer's disease.
Lukiw WJ, Bazan NG., Neurochem Res 25(9-10), 2000
PMID: 11059791
The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease.
Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F, Inestrosa NC., Prog Neurobiol 62(6), 2000
PMID: 10880853
NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival.
Denk A, Wirth T, Baumann B., Cytokine Growth Factor Rev 11(4), 2000
PMID: 10959078
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative.
Collins JS, Perry RT, Watson B, Harrell LE, Acton RT, Blacker D, Albert MS, Tanzi RE, Bassett SS, McInnis MG, Campbell RD, Go RC., Am J Med Genet 96(6), 2000
PMID: 11121190
Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro.
Post A, Crochemore C, Uhr M, Holsboer F, Behl C., Eur J Neurosci 12(12), 2000
PMID: 11122343
Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-kappaB.
Ginis I, Hallenbeck JM, Liu J, Spatz M, Jaiswal R, Shohami E., Mol Med 6(12), 2000
PMID: 11474119
Activation of NF-kappa B by reactive oxygen intermediates in the nervous system.
Kaltschmidt B, Sparna T, Kaltschmidt C., Antioxid Redox Signal 1(2), 1999
PMID: 11228742
Regulation of amyloid precursor protein cleavage.
Mills J, Reiner PB., J Neurochem 72(2), 1999
PMID: 9930716
Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia.
Gabriel C, Justicia C, Camins A, Planas AM., Brain Res Mol Brain Res 65(1), 1999
PMID: 10036308
Mechanisms of apoptosis in PC12 cells irreversibly differentiated with nerve growth factor and cyclic AMP.
Lambeng N, Michel PP, Brugg B, Agid Y, Ruberg M., Brain Res 821(1), 1999
PMID: 10064788
Characterization of a neuronal kappaB-binding factor distinct from NF-kappaB.
Moerman AM, Mao X, Lucas MM, Barger SW., Brain Res Mol Brain Res 67(2), 1999
PMID: 10216229
The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages.
Van Muiswinkel FL, Raupp SF, de Vos NM, Smits HA, Verhoef J, Eikelenboom P, Nottet HS., J Neuroimmunol 96(1), 1999
PMID: 10227431
NF-kappaB is activated and promotes cell death in focal cerebral ischemia.
Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M., Nat Med 5(5), 1999
PMID: 10229233
Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators.
Kaltschmidt B, Kaltschmidt C, Hehner SP, Dröge W, Schmitz ML., Oncogene 18(21), 1999
PMID: 10359527
Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity.
Botchkina GI, Geimonen E, Bilof ML, Villarreal O, Tracey KJ., Mol Med 5(6), 1999
PMID: 10415162
Anti-inflammatory substances - a new therapeutic option in Alzheimer's disease.
Hüll M, Fiebich BL, Schumann G, Lieb K, Bauer J., Drug Discov Today 4(6), 1999
PMID: 10354542
Is NF-kappaB the sensor of oxidative stress?
Li N, Karin M., FASEB J 13(10), 1999
PMID: 10385605
Identification of beta-amyloid-responsive genes by RNA differential display: early induction of a DNA damage-inducible gene, gadd45.
Santiard-Baron D, Gosset P, Nicole A, Sinet PM, Christen Y, Ceballos-Picot I., Exp Neurol 158(1), 1999
PMID: 10448433
Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis.
Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C., Proc Natl Acad Sci U S A 96(16), 1999
PMID: 10430956
Interleukin-17 stimulates the expression of IkappaB alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines.
Kehlen A, Thiele K, Riemann D, Rainov N, Langner J., J Neuroimmunol 101(1), 1999
PMID: 10580807
Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice.
Kim JI, Ju WK, Choi JH, Choi E, Carp RI, Wisniewski HM, Kim YS., Brain Res Mol Brain Res 73(1-2), 1999
PMID: 10581394
Control of apoptosis by Rel/NF-kappaB transcription factors.
Barkett M, Gilmore TD., Oncogene 18(49), 1999
PMID: 10602466
Alzheimer's disease and brain development: common molecular pathways.
Jordan-Sciutto K, Bowser R., Front Biosci 3(), 1998
PMID: 9422711
Early glycoxidation damage in brains from Down's syndrome.
Odetti P, Angelini G, Dapino D, Zaccheo D, Garibaldi S, Dagna-Bricarelli F, Piombo G, Perry G, Smith M, Traverso N, Tabaton M., Biochem Biophys Res Commun 243(3), 1998
PMID: 9501012
NF-kappaB modulates lipopolysaccharide-induced microglial nerve growth factor expression.
Heese K, Fiebich BL, Bauer J, Otten U., Glia 22(4), 1998
PMID: 9517572
Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism.
Akama KT, Albanese C, Pestell RG, Van Eldik LJ., Proc Natl Acad Sci U S A 95(10), 1998
PMID: 9576964
NF-kB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease.
Ferrer I, Martí E, López E, Tortosa A., Neuropathol Appl Neurobiol 24(4), 1998
PMID: 9775392
Expression of FAC1 in activated microglia during Alzheimer's disease.
Bowser R, Reilly S., Neurosci Lett 253(3), 1998
PMID: 9792236
The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease.
Aksenov MY, Tucker HM, Nair P, Aksenova MV, Butterfield DA, Estus S, Markesbery WR., J Mol Neurosci 11(2), 1998
PMID: 10096042
Familial Alzheimer's disease: oxidative stress, beta-amyloid, presenilins, and cell death.
Velez-Pardo C, Jimenez Del Rio M, Lopera F., Gen Pharmacol 31(5), 1998
PMID: 9809462
Nuclear factor kappa B: important transcription factor and therapeutic target.
Lee JI, Burckart GJ., J Clin Pharmacol 38(11), 1998
PMID: 9824778
NF-kappa B: a crucial transcription factor for glial and neuronal cell function.
O'Neill LA, Kaltschmidt C., Trends Neurosci 20(6), 1997
PMID: 9185306
Gene expression induced by cerebral ischemia: an apoptotic perspective.
MacManus JP, Linnik MD., J Cereb Blood Flow Metab 17(8), 1997
PMID: 9290580
Antioxidant defense of the brain: a role for astrocytes.
Wilson JX., Can J Physiol Pharmacol 75(10-11), 1997
PMID: 9431439
Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains.
Kitamura Y, Shimohama S, Ota T, Matsuoka Y, Nomura Y, Taniguchi T., Neurosci Lett 237(1), 1997
PMID: 9406869

49 References

Daten bereitgestellt von Europe PubMed Central.

Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.
Schubert W, Prior R, Weidemann A, Dircksen H, Multhaup G, Masters CL, Beyreuther K., Brain Res. 563(1-2), 1991
PMID: 1786532
Vitamin E protects nerve cells from amyloid beta protein toxicity.
Behl C, Davis J, Cole GM, Schubert D., Biochem. Biophys. Res. Commun. 186(2), 1992
PMID: 1497677
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
Yankner BA, Duffy LK, Kirschner DA., Science 250(4978), 1990
PMID: 2218531
Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.
Staal FJ, Roederer M, Herzenberg LA, Herzenberg LA., Proc. Natl. Acad. Sci. U.S.A. 87(24), 1990
PMID: 2263644
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B., Nature 325(6106), 1987
PMID: 2881207
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K., Proc. Natl. Acad. Sci. U.S.A. 82(12), 1985
PMID: 3159021
Inflammatory mechanisms in Alzheimer's disease: implications for therapy.
Aisen PS, Davis KL., Am J Psychiatry 151(8), 1994
PMID: 7518651
Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine.
Minc-Golomb D, Tsarfaty I, Schwartz JP., Br. J. Pharmacol. 112(3), 1994
PMID: 7522856
Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.
Guerrini L, Blasi F, Denis-Donini S., Proc. Natl. Acad. Sci. U.S.A. 92(20), 1995
PMID: 7568076
Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.
Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Proc. Natl. Acad. Sci. U.S.A. 92(21), 1995
PMID: 7568184
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S., Genes Dev. 9(22), 1995
PMID: 7590248
Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene.
Grilli M, Ribola M, Alberici A, Valerio A, Memo M, Spano P., J. Biol. Chem. 270(45), 1995
PMID: 7592914
Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B.
Schmidt KN, Traenckner EB, Meier B, Baeuerle PA., J. Biol. Chem. 270(45), 1995
PMID: 7592968
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B.
Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D., Nature 376(6536), 1995
PMID: 7603567
Selective recognition of the activated form of transcription factor NF-kappa B by a monoclonal antibody.
Kaltschmidt C, Kaltschmidt B, Henkel T, Stockinger H, Baeuerle PA., Biol. Chem. Hoppe-Seyler 376(1), 1995
PMID: 7612189
Induction of MHC class I genes in neurons.
Neumann H, Cavalie A, Jenne DE, Wekerle H., Science 269(5223), 1995
PMID: 7624779
Glial cytokines in Alzheimer's disease: review and pathogenic implications.
Mrak RE, Sheng JG, Griffin WS., Hum. Pathol. 26(8), 1995
PMID: 7635444
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L., Proc. Natl. Acad. Sci. U.S.A. 90(21), 1993
PMID: 7694279
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ.
Lassmann H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM., Acta Neuropathol. 89(1), 1995
PMID: 7709729
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisoda SS, Chen HY, Van der Ploeg LH., Cell 81(4), 1995
PMID: 7758106
Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures.
Del Bo R, Angeretti N, Lucca E, De Simoni MG, Forloni G., Neurosci. Lett. 188(1), 1995
PMID: 7783982
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F., Nature 373(6514), 1995
PMID: 7845465
Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution.
Griffin WS, Sheng JG, Roberts GW, Mrak RE., J. Neuropathol. Exp. Neurol. 54(2), 1995
PMID: 7876895
Oxidative stress, glutamate, and neurodegenerative disorders.
Coyle JT, Puttfarcken P., Science 262(5134), 1993
PMID: 7901908
Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.
Verbeek MM, Otte-Holler I, Westphal JR, Wesseling P, Ruiter DJ, de Waal RM., Am. J. Pathol. 144(1), 1994
PMID: 7904796
Transcription factor NF-kappa B is activated in microglia during experimental autoimmune encephalomyelitis.
Kaltschmidt C, Kaltschmidt B, Lannes-Vieira J, Kreutzberg GW, Wekerle H, Baeuerle PA, Gehrmann J., J. Neuroimmunol. 55(1), 1994
PMID: 7962486
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.
Muller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rulicke T, Brandner S, Aguzzi A, Weissmann C., Cell 79(5), 1994
PMID: 8001115
Hydrogen peroxide mediates amyloid beta protein toxicity.
Behl C, Davis JB, Lesley R, Schubert D., Cell 77(6), 1994
PMID: 8004671
Function and activation of NF-kappa B in the immune system.
Baeuerle PA, Henkel T., Annu. Rev. Immunol. 12(), 1994
PMID: 8011280
Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.
Liou HC, Sha WC, Scott ML, Baltimore D., Mol. Cell. Biol. 14(8), 1994
PMID: 8035813
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.
Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF, Floyd RA, Butterfield DA., Proc. Natl. Acad. Sci. U.S.A. 91(8), 1994
PMID: 8159737
Constitutive NF-kappa B activity in neurons.
Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA., Mol. Cell. Biol. 14(6), 1994
PMID: 8196637
Brain synapses contain inducible forms of the transcription factor NF-kappa B.
Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Mech. Dev. 43(2-3), 1993
PMID: 8297787
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B.
Henkel T, Machleidt T, Alkalay I, Kronke M, Ben-Neriah Y, Baeuerle PA., Nature 365(6442), 1993
PMID: 8371761
The NF-kappa B p65 promoter.
Ueberla K, Lu Y, Chung E, Haseltine WA., J. Acquir. Immune Defic. Syndr. 6(3), 1993
PMID: 8450395
Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.
Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Matthaei R, Baeuerle PA, Barde YA., Science 272(5261), 1996
PMID: 8614802
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.
Li ZW, Stark G, Gotz J, Rulicke T, Gschwind M, Huber G, Muller U, Weissmann C., Proc. Natl. Acad. Sci. U.S.A. 93(12), 1996
PMID: 8650236
TrkA activation is sufficient to rescue axotomized cholinergic neurons.
Lucidi-Phillipi CA, Clary DO, Reichardt LF, Gage FH., Neuron 16(3), 1996
PMID: 8785062
Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients.
Strauss S, Bauer J, Ganter U, Jonas U, Berger M, Volk B., Lab. Invest. 66(2), 1992
PMID: 1370967

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 9122249
PubMed | Europe PMC

Suchen in

Google Scholar