"Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue

Nahrwold M, Bogner T, Eissler S, Verma S, Sewald N (2010)
ORGANIC LETTERS 12(5): 1064-1067.

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Abstract
An endocyclic trans-amide linkage within the macrocyclic antitumor agent cryptophycin-52 was replaced by a 1,4-disubstituted 1H-1,2,3-triazole ring. Macrocyclisation of the triazole analogue was accomplished by macrolactamization as well as by Cu(I)-mediated "click"-cyclization. Compared to cryptophycin-52, in vitro cytotoxicity of "clicktophycin-52" against the multidrug resistant human cancer cell line KB-V1 is only slightly reduced.
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Nahrwold M, Bogner T, Eissler S, Verma S, Sewald N. "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. ORGANIC LETTERS. 2010;12(5):1064-1067.
Nahrwold, M., Bogner, T., Eissler, S., Verma, S., & Sewald, N. (2010). "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. ORGANIC LETTERS, 12(5), 1064-1067. doi:10.1021/ol1000473
Nahrwold, M., Bogner, T., Eissler, S., Verma, S., and Sewald, N. (2010). "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. ORGANIC LETTERS 12, 1064-1067.
Nahrwold, M., et al., 2010. "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. ORGANIC LETTERS, 12(5), p 1064-1067.
M. Nahrwold, et al., “"Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue”, ORGANIC LETTERS, vol. 12, 2010, pp. 1064-1067.
Nahrwold, M., Bogner, T., Eissler, S., Verma, S., Sewald, N.: "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. ORGANIC LETTERS. 12, 1064-1067 (2010).
Nahrwold, Markus, Bogner, Tobias, Eissler, Stefan, Verma, Spart, and Sewald, Norbert. “"Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue”. ORGANIC LETTERS 12.5 (2010): 1064-1067.
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15 Citations in Europe PMC

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