ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE

Brunetti M, Sepede G, Mingoia G, Catani C, Ferretti A, Merla A, Del Gratta C, Romani GL, Babiloni C (2010)
NEUROSCIENCE 168(3): 670-679.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Previous evidence from functional magnetic resonance imaging (fMRI) studies has shown that amygdala responses to emotionally neutral pictures are exaggerated at a group level in patients with severe post-traumatic stress disorder (PTSD) [Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A (2003) Neuroimage 19(3):587-600]. The present fMRI study tested the hypothesis that amygdala responses are elevated not only in response to negative pictures but also to neutral pictures as a function of disease severity in patients with mild symptoms and in subjects who did not develop symptoms. To this end, fMRI scans were performed in 10 patients with mild PTSD and 10 healthy controls (both victims of a bank robbery), during the execution of a visuo-attentional task in which they were asked to observe emotionally negative or neutral pictures. Control subjects showed enhanced amygdala responses to emotionally negative stimuli compared to neutral stimuli. On the contrary, PTSD patients were characterized by high amygdala responses to both neutral and emotional pictures, with no statistically significant difference between the two classes of stimuli. In the entire group, we found correlations among the severity of the PTSD symptoms, task performance, and amygdala activation during the processing of neutral stimuli. Results of this study suggest that amygdala responses and the selectivity of the emotional response to neutral stimuli are elevated as a function of disease severity in PTSD patients with mild symptoms. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
NEUROSCIENCE
Band
168
Zeitschriftennummer
3
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670-679
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Brunetti M, Sepede G, Mingoia G, et al. ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE. 2010;168(3):670-679.
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., et al. (2010). ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE, 168(3), 670-679. doi:10.1016/j.neuroscience.2010.04.024
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G. L., and Babiloni, C. (2010). ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE 168, 670-679.
Brunetti, M., et al., 2010. ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE, 168(3), p 670-679.
M. Brunetti, et al., “ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE”, NEUROSCIENCE, vol. 168, 2010, pp. 670-679.
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G.L., Babiloni, C.: ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE. 168, 670-679 (2010).
Brunetti, M., Sepede, G., Mingoia, G., Catani, Claudia, Ferretti, A., Merla, A., Del Gratta, C., Romani, G. L., and Babiloni, C. “ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE”. NEUROSCIENCE 168.3 (2010): 670-679.

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Children prenatally exposed to maternal anxiety devote more attentional resources to neutral pictures.
van den Heuvel MI, Henrichs J, Donkers FCL, Van den Bergh BRH., Dev Sci 21(4), 2018
PMID: 29057552
Large-scale brain organization during facial emotion processing as a function of early life trauma among adolescent girls.
Cisler JM, Privratsky A, Smitherman S, Herringa RJ, Kilts CD., Neuroimage Clin 17(), 2018
PMID: 29527485
White matter integrity alterations in post-traumatic stress disorder.
O'Doherty DCM, Ryder W, Paquola C, Tickell A, Chan C, Hermens DF, Bennett MR, Lagopoulos J., Hum Brain Mapp 39(3), 2018
PMID: 29265681
The Associations Between Oxytocin and Trauma in Humans: A Systematic Review.
Donadon MF, Martin-Santos R, Osório FL., Front Pharmacol 9(), 2018
PMID: 29545749
Functional Neuroanatomy of Emotion and Its Regulation in PTSD.
Fitzgerald JM, DiGangi JA, Phan KL., Harv Rev Psychiatry 26(3), 2018
PMID: 29734226
Resilience and cross-network connectivity: A neural model for post-trauma survival.
Brunetti M, Marzetti L, Sepede G, Zappasodi F, Pizzella V, Sarchione F, Vellante F, Martinotti G, Di Giannantonio M., Prog Neuropsychopharmacol Biol Psychiatry 77(), 2017
PMID: 28408294
Salivary biomarkers of neural hypervigilance in trauma-exposed women.
Yoon SA, Weierich MR., Psychoneuroendocrinology 63(), 2016
PMID: 26398002
Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients.
Koch SB, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M., Neuropsychopharmacology 41(6), 2016
PMID: 26404844
Brain Activity in Response to Trauma-specific, Negative, and Neutral Stimuli. A fMRI Study of Recent Road Traffic Accident Survivors.
Nilsen AS, Blix I, Leknes S, Ekeberg Ø, Skogstad L, Endestad T, Østberg BC, Heir T., Front Psychol 7(), 2016
PMID: 27547195
Neural correlates of trauma-unrelated emotional processing in war veterans with PTSD.
van Rooij SJ, Rademaker AR, Kennis M, Vink M, Kahn RS, Geuze E., Psychol Med 45(3), 2015
PMID: 25036523
White matter abnormalities in Gulf War veterans with posttraumatic stress disorder: A pilot study.
Bierer LM, Ivanov I, Carpenter DM, Wong EW, Golier JA, Tang CY, Yehuda R., Psychoneuroendocrinology 51(), 2015
PMID: 25465169
Learning models of PTSD: Theoretical accounts and psychobiological evidence.
Lissek S, van Meurs B., Int J Psychophysiol 98(3 pt 2), 2015
PMID: 25462219
Response inhibition failure to visual stimuli paired with a "single-type" stressor in PTSD patients: an fMRI pilot study.
Brunetti M, Sepede G, Ferretti A, Mingoia G, Romani GL, Babiloni C., Brain Res Bull 114(), 2015
PMID: 25791360
BDNF concentration and impulsiveness level in post-traumatic stress disorder.
Martinotti G, Sepede G, Brunetti M, Ricci V, Gambi F, Chillemi E, Vellante F, Signorelli M, Pettorruso M, De Risio L, Aguglia E, Angelucci F, Caltagirone C, Di Giannantonio M., Psychiatry Res 229(3), 2015
PMID: 26277035
Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing.
Opmeer EM, Kortekaas R, van Tol MJ, van der Wee NJ, Woudstra S, van Buchem MA, Penninx BW, Veltman DJ, Aleman A., Soc Cogn Affect Neurosci 9(5), 2014
PMID: 23482625
Effects of stress on AMPA receptor distribution and function in the basolateral amygdala.
Hubert GW, Li C, Rainnie DG, Muly EC., Brain Struct Funct 219(4), 2014
PMID: 23644586
Neural activation during response inhibition differentiates blast from mechanical causes of mild to moderate traumatic brain injury.
Fischer BL, Parsons M, Durgerian S, Reece C, Mourany L, Lowe MJ, Beall EB, Koenig KA, Jones SE, Newsome MR, Scheibel RS, Wilde EA, Troyanskaya M, Merkley TL, Walker M, Levin HS, Rao SM., J Neurotrauma 31(2), 2014
PMID: 24020449
BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure.
Angelucci F, Ricci V, Gelfo F, Martinotti G, Brunetti M, Sepede G, Signorelli M, Aguglia E, Pettorruso M, Vellante F, Di Giannantonio M, Caltagirone C., Brain Cogn 84(1), 2014
PMID: 24362070
Thermal signature of fear conditioning in mild post traumatic stress disorder.
Di Giacinto A, Brunetti M, Sepede G, Ferretti A, Merla A., Neuroscience 266(), 2014
PMID: 24561216
Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women.
Outhred T, Das P, Felmingham KL, Bryant RA, Nathan PJ, Malhi GS, Kemp AH., J Psychiatry Neurosci 39(4), 2014
PMID: 24690370
NMDA receptor dysregulation in chronic state: a possible mechanism underlying depression with BDNF downregulation.
Vásquez CE, Riener R, Reynolds E, Britton GB., Neurochem Int 79(), 2014
PMID: 25277075
Neural, psychophysiological, and behavioral markers of fear processing in PTSD: a review of the literature.
Shvil E, Rusch HL, Sullivan GM, Neria Y., Curr Psychiatry Rep 15(5), 2013
PMID: 23619614
Structural and functional connectivity changes in the brain associated with shyness but not with social anxiety.
Yang X, Kendrick KM, Wu Q, Chen T, Lama S, Cheng B, Li S, Huang X, Gong Q., PLoS One 8(5), 2013
PMID: 23675458
Atypical visual processing in posttraumatic stress disorder.
Mueller-Pfeiffer C, Schick M, Schulte-Vels T, O'Gorman R, Michels L, Martin-Soelch C, Blair JR, Rufer M, Schnyder U, Zeffiro T, Hasler G., Neuroimage Clin 3(), 2013
PMID: 24371791
Age and cortisol levels modulate judgment of positive and negative facial expressions.
Feeney J, Gaffney P, O'Mara SM., Psychoneuroendocrinology 37(6), 2012
PMID: 22032891
Increased white matter integrity of posterior cingulate gyrus in the evolution of post-traumatic stress disorder.
Zhang L, Li W, Shu N, Zheng H, Zhang Z, Zhang Y, He Z, Hou C, Li Z, Liu J, Wang L, Duan L, Jiang T, Li L., Acta Neuropsychiatr 24(1), 2012
PMID: 25288457
Brain activation to facial expressions in youth with PTSD symptoms.
Garrett AS, Carrion V, Kletter H, Karchemskiy A, Weems CF, Reiss A., Depress Anxiety 29(5), 2012
PMID: 22553009
Quantitative meta-analysis of neural activity in posttraumatic stress disorder.
Hayes JP, Hayes SM, Mikedis AM., Biol Mood Anxiety Disord 2(), 2012
PMID: 22738125
Recovery from anorexia nervosa includes neural compensation for negative body image.
Pruis TA, Keel PK, Janowsky JS., Int J Eat Disord 45(8), 2012
PMID: 22729811
Functional neuroimaging studies of post-traumatic stress disorder.
Hughes KC, Shin LM., Expert Rev Neurother 11(2), 2011
PMID: 21306214
Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions.
Zhang L, Zhang Y, Li L, Li Z, Li W, Ma N, Hou C, Zhang Z, Zhang Z, Wang L, Duan L, Lu G., J Affect Disord 133(1-2), 2011
PMID: 21497403
Does reconsolidation occur in humans?
Schiller D, Phelps EA., Front Behav Neurosci 5(), 2011
PMID: 21629821
Oxytocin reduces background anxiety in a fear-potentiated startle paradigm: peripheral vs central administration.
Ayers LW, Missig G, Schulkin J, Rosen JB., Neuropsychopharmacology 36(12), 2011
PMID: 21796104
5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior.
Strong PV, Christianson JP, Loughridge AB, Amat J, Maier SF, Fleshner M, Greenwood BN., Neuroscience 197(), 2011
PMID: 21958863

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