ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE

Brunetti M, Sepede G, Mingoia G, Catani C, Ferretti A, Merla A, Del Gratta C, Romani GL, Babiloni C (2010)
NEUROSCIENCE 168(3): 670-679.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ; ; ;
Abstract / Bemerkung
Previous evidence from functional magnetic resonance imaging (fMRI) studies has shown that amygdala responses to emotionally neutral pictures are exaggerated at a group level in patients with severe post-traumatic stress disorder (PTSD) [Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A (2003) Neuroimage 19(3):587-600]. The present fMRI study tested the hypothesis that amygdala responses are elevated not only in response to negative pictures but also to neutral pictures as a function of disease severity in patients with mild symptoms and in subjects who did not develop symptoms. To this end, fMRI scans were performed in 10 patients with mild PTSD and 10 healthy controls (both victims of a bank robbery), during the execution of a visuo-attentional task in which they were asked to observe emotionally negative or neutral pictures. Control subjects showed enhanced amygdala responses to emotionally negative stimuli compared to neutral stimuli. On the contrary, PTSD patients were characterized by high amygdala responses to both neutral and emotional pictures, with no statistically significant difference between the two classes of stimuli. In the entire group, we found correlations among the severity of the PTSD symptoms, task performance, and amygdala activation during the processing of neutral stimuli. Results of this study suggest that amygdala responses and the selectivity of the emotional response to neutral stimuli are elevated as a function of disease severity in PTSD patients with mild symptoms. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
NEUROSCIENCE
Band
168
Zeitschriftennummer
3
Seite
670-679
ISSN
PUB-ID

Zitieren

Brunetti M, Sepede G, Mingoia G, et al. ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE. 2010;168(3):670-679.
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., et al. (2010). ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE, 168(3), 670-679. doi:10.1016/j.neuroscience.2010.04.024
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G. L., and Babiloni, C. (2010). ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE 168, 670-679.
Brunetti, M., et al., 2010. ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE, 168(3), p 670-679.
M. Brunetti, et al., “ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE”, NEUROSCIENCE, vol. 168, 2010, pp. 670-679.
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G.L., Babiloni, C.: ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE. NEUROSCIENCE. 168, 670-679 (2010).
Brunetti, M., Sepede, G., Mingoia, G., Catani, Claudia, Ferretti, A., Merla, A., Del Gratta, C., Romani, G. L., and Babiloni, C. “ELEVATED RESPONSE OF HUMAN AMYGDALA TO NEUTRAL STIMULI IN MILD POST TRAUMATIC STRESS DISORDER: NEURAL CORRELATES OF GENERALIZED EMOTIONAL RESPONSE”. NEUROSCIENCE 168.3 (2010): 670-679.

36 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing.
Opmeer EM, Kortekaas R, van Tol MJ, van der Wee NJ, Woudstra S, van Buchem MA, Penninx BW, Veltman DJ, Aleman A., Soc Cogn Affect Neurosci 9(5), 2014
PMID: 23482625
Age and cortisol levels modulate judgment of positive and negative facial expressions.
Feeney J, Gaffney P, O'Mara SM., Psychoneuroendocrinology 37(6), 2012
PMID: 22032891
Increased white matter integrity of posterior cingulate gyrus in the evolution of post-traumatic stress disorder.
Zhang L, Li W, Shu N, Zheng H, Zhang Z, Zhang Y, He Z, Hou C, Li Z, Liu J, Wang L, Duan L, Jiang T, Li L., Acta Neuropsychiatr 24(1), 2012
PMID: 25288457
Brain activation to facial expressions in youth with PTSD symptoms.
Garrett AS, Carrion V, Kletter H, Karchemskiy A, Weems CF, Reiss A., Depress Anxiety 29(5), 2012
PMID: 22553009
Quantitative meta-analysis of neural activity in posttraumatic stress disorder.
Hayes JP, Hayes SM, Mikedis AM., Biol Mood Anxiety Disord 2(), 2012
PMID: 22738125
Recovery from anorexia nervosa includes neural compensation for negative body image.
Pruis TA, Keel PK, Janowsky JS., Int J Eat Disord 45(8), 2012
PMID: 22729811
Functional neuroimaging studies of post-traumatic stress disorder.
Hughes KC, Shin LM., Expert Rev Neurother 11(2), 2011
PMID: 21306214
Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions.
Zhang L, Zhang Y, Li L, Li Z, Li W, Ma N, Hou C, Zhang Z, Zhang Z, Wang L, Duan L, Lu G., J Affect Disord 133(1-2), 2011
PMID: 21497403
Does reconsolidation occur in humans?
Schiller D, Phelps EA., Front Behav Neurosci 5(), 2011
PMID: 21629821
Oxytocin reduces background anxiety in a fear-potentiated startle paradigm: peripheral vs central administration.
Ayers LW, Missig G, Schulkin J, Rosen JB., Neuropsychopharmacology 36(12), 2011
PMID: 21796104
5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior.
Strong PV, Christianson JP, Loughridge AB, Amat J, Maier SF, Fleshner M, Greenwood BN., Neuroscience 197(), 2011
PMID: 21958863

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 20416363
PubMed | Europe PMC

Suchen in

Google Scholar