Bioactive Steroidal Alkaloids from Sarcococca hookeriana

Devkota KP, Wansi J, Lenta BN, Khan S, Choudhary MI, Sewald N (2010)
PLANTA MEDICA 76(10): 1022-1025.

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Abstract
Four new 5 alpha-pregnane-type steroidal alkaloids, hookerianamides L (1), M (2), N (3), and O (4), and a known N-formylchonemorphine (5) have been isolated by acid-base extraction of the dichloromethane extract of Sarcococca hookeriana. The structures of all compounds were determined with spectroscopic techniques and by comparison with literature data. All compounds displayed antileishmanial and antibacterial properties. Compounds 1, 4, and 5 were found to be more potent than standard pentamidine (IC50 = 9.59 mu g/mL) with respect to leishmanicidal activity. The minimum inhibitory concentration of most of the compounds against Bacillus subtilis, Streptococcus minor, and Streptococcus ferus was lower than that of the standard ampicillin.
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Devkota KP, Wansi J, Lenta BN, Khan S, Choudhary MI, Sewald N. Bioactive Steroidal Alkaloids from Sarcococca hookeriana. PLANTA MEDICA. 2010;76(10):1022-1025.
Devkota, K. P., Wansi, J., Lenta, B. N., Khan, S., Choudhary, M. I., & Sewald, N. (2010). Bioactive Steroidal Alkaloids from Sarcococca hookeriana. PLANTA MEDICA, 76(10), 1022-1025.
Devkota, K. P., Wansi, J., Lenta, B. N., Khan, S., Choudhary, M. I., and Sewald, N. (2010). Bioactive Steroidal Alkaloids from Sarcococca hookeriana. PLANTA MEDICA 76, 1022-1025.
Devkota, K.P., et al., 2010. Bioactive Steroidal Alkaloids from Sarcococca hookeriana. PLANTA MEDICA, 76(10), p 1022-1025.
K.P. Devkota, et al., “Bioactive Steroidal Alkaloids from Sarcococca hookeriana”, PLANTA MEDICA, vol. 76, 2010, pp. 1022-1025.
Devkota, K.P., Wansi, J., Lenta, B.N., Khan, S., Choudhary, M.I., Sewald, N.: Bioactive Steroidal Alkaloids from Sarcococca hookeriana. PLANTA MEDICA. 76, 1022-1025 (2010).
Devkota, Krishna Prasad, Wansi, Jean, Lenta, Bruno N., Khan, Samreen, Choudhary, Muhammad I., and Sewald, Norbert. “Bioactive Steroidal Alkaloids from Sarcococca hookeriana”. PLANTA MEDICA 76.10 (2010): 1022-1025.
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Pregnane alkaloids from Sarcococca hookeriana var. digyna.
Zhang PZ, Wang F, Yang LJ, Zhang GL., Fitoterapia 89(), 2013
PMID: 23651560

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