Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes

Ragg H, Kumar A, Köster K, Bentele C, Wang Y, Frese M-A, Prib N, Krüger O (2009)
BMC Evolutionary Biology 9(1).

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Background: Intron gains reportedly are very rare during evolution of vertebrates, and the mechanisms underlying their creation are largely unknown. Previous investigations have shown that, during metazoan radiation, the exon-intron patterns of serpin superfamily genes were subject to massive changes, in contrast to many other genes. Results: Here we investigated intron dynamics in the serpin superfamily in lineages pre- and postdating the split of vertebrates. Multiple intron gains were detected in a group of ray-finned fishes, once the canonical groups of vertebrate serpins had been established. In two genes, cooccurrence of non-standard introns was observed, implying that intron gains in vertebrates may even happen concomitantly or in a rapidly consecutive manner. DNA breakage/repair processes associated with genome compaction are introduced as a novel factor potentially favoring intron gain, since all non-canonical introns were found in a lineage of ray-finned fishes that experienced genomic downsizing. Conclusion: Multiple intron acquisitions were identified in serpin genes of a lineage of ray-finned fishes, but not in any other vertebrates, suggesting that insertion rates for introns may be episodically increased. The co-occurrence of non-standard introns within the same gene discloses the possibility that introns may be gained simultaneously. The sequences flanking the intron insertion points correspond to the proto-splice site consensus sequence MAG↑N, previously proposed to serve as intron insertion site. The association of intron gains in the serpin superfamily with a group of fishes that underwent genome compaction may indicate that DNA breakage/repair processes might foster intron birth.
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Ragg H, Kumar A, Köster K, et al. Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes. BMC Evolutionary Biology. 2009;9(1).
Ragg, H., Kumar, A., Köster, K., Bentele, C., Wang, Y., Frese, M. - A., Prib, N., et al. (2009). Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes. BMC Evolutionary Biology, 9(1).
Ragg, H., Kumar, A., Köster, K., Bentele, C., Wang, Y., Frese, M. - A., Prib, N., and Krüger, O. (2009). Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes. BMC Evolutionary Biology 9.
Ragg, H., et al., 2009. Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes. BMC Evolutionary Biology, 9(1).
H. Ragg, et al., “Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes”, BMC Evolutionary Biology, vol. 9, 2009.
Ragg, H., Kumar, A., Köster, K., Bentele, C., Wang, Y., Frese, M.-A., Prib, N., Krüger, O.: Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes. BMC Evolutionary Biology. 9, (2009).
Ragg, Hermann, Kumar, Abhishek, Köster, Katharina, Bentele, Caterina, Wang, Yunjie, Frese, Marc-Andre, Prib, Natalie, and Krüger, Olaf. “Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes”. BMC Evolutionary Biology 9.1 (2009).
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