Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing

Krämer A, Herth D, von Keyserlingk H, Ludwig WD, Hampl H, Sommer D, Hahn EG, Riecken E-O (1988)
Klinische Wochenschrift 66(15): 670-674.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The variation in immune responses to standard inoculation of the hepatitis-B virus vaccine suggest that host factors influence response in ways that are not presently understood. We studied 25 low/nonresponding health care workers (anti-HBs titer <50 IU/l) after the third inoculation of an experimental hepatitis-B vaccine to determine their immune status (through lymphocyte phenotypes) and HLA type. After application of a fourth inoculation, the seroconverting subjects showed only low anti-HBs levels; three male subjects remained anti-HBs negative. Twelve months after the fourth inoculation only 9 of 25 subjects (36%) maintained anti-HBs titer >10 IU/l. Almost all subjects had normal B-cell and CD-4 and CD-8 counts and ratios. Relative to other European populations HLA-A-10 (P<0.05), B-12 (P<0.025), CW-5 (P<0.05), DR-3 (P<0.025), and DR-5 (P<0.025) were increased, whereas DR-2 (P<0.05) was decreased. However, after correction of theP-values for the number of HLA antigens determined, these differences were no longer significant. Furthermore, these HLA types were not the same as those reported in other studies (except for DR-3). We suggest that larger sample sizes or even not yet available immunogenetic markers will be required to prove an "immunogenetic background" in low/nonresponders, if it exists.
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Zeitschriftentitel
Klinische Wochenschrift
Band
66
Zeitschriftennummer
15
Seite
670-674
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Krämer A, Herth D, von Keyserlingk H, et al. Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift. 1988;66(15):670-674.
Krämer, A., Herth, D., von Keyserlingk, H., Ludwig, W. D., Hampl, H., Sommer, D., Hahn, E. G., et al. (1988). Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift, 66(15), 670-674. doi:10.1007/BF01726924
Krämer, A., Herth, D., von Keyserlingk, H., Ludwig, W. D., Hampl, H., Sommer, D., Hahn, E. G., and Riecken, E. - O. (1988). Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift 66, 670-674.
Krämer, A., et al., 1988. Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift, 66(15), p 670-674.
A. Krämer, et al., “Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing”, Klinische Wochenschrift, vol. 66, 1988, pp. 670-674.
Krämer, A., Herth, D., von Keyserlingk, H., Ludwig, W.D., Hampl, H., Sommer, D., Hahn, E.G., Riecken, E.-O.: Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift. 66, 670-674 (1988).
Krämer, Alexander, Herth, D., von Keyserlingk, H., Ludwig, W. D., Hampl, Hartmut, Sommer, D., Hahn, E. G., and Riecken, Ernst-Otto. “Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing”. Klinische Wochenschrift 66.15 (1988): 670-674.
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5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth.
Li Y, Ni R, Song W, Shao W, Shrestha S, Ahmad S, Cunningham CK, Flynn PM, Kapogiannis BG, Wilson CM, Tang J., Hum Genet 126(5), 2009
PMID: 19597844
Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules.
Stachowski J, Barth C, Pollok M, Michałkiewicz J, Madaliński K, Maciejewski J, Baldamis CA., Mediators Inflamm 4(1), 1995
PMID: 18475616
Relationship between the reactivity to hepatitis B virus vaccination and the frequency of MHC class I, II and III alleles in haemodialysis patients.
Stachowski J, Kramer J, Füst G, Maciejewski J, Baldamus CA, Petrányi GG., Scand J Immunol 42(1), 1995
PMID: 7631146
The immune response to hepatitis B vaccine in humans: inheritance patterns in families.
Kruskall MS, Alper CA, Awdeh Z, Yunis EJ, Marcus-Bagley D., J Exp Med 175(2), 1992
PMID: 1531063
Influence of vaccination schedules and host factors on antibody response following hepatitis B vaccination.
Hess G, Hingst V, Cseke J, Bock HL, Clemens R., Eur J Clin Microbiol Infect Dis 11(4), 1992
PMID: 1396753

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