Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection

Fuchs D, Krämer A, Reibnegger G, Werner ER, Dierich MP, Goedert JJ, Wachter H (1991)
Infection 19(S2): S98-S102.

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Abstract / Bemerkung
Die Mehrheit der mit dem humanen Immundefizienzvirus Typ 1 (HIV-1) infizierten Personen ist frei von Symptomen oder weist nur persistierende Lymphadenopathie auf. Es ist notwendig, Risikokriterien für das Fortschreiten der Erkrankung zu erstellen, um zeitgerecht prophylaktische Maßnahmen einleiten zu können. Die Zahl der CD4-positiven Zellen ist ein geeigneter Prognoseparameter. Die Zellzählung ist jedoch aufwendig, teuer und Speziallabors vorbehalten, sodaß zusätzliche einfache Untersuchungen erwünscht sind, um die Risikoabschätzung weiter zu verbessern. Wissenschaftliche Untersuchungen ergaben, daß Neopterin und [beta]2- Mikroglobulin bei der HIV-1 Infektion gleich gute Prognoseparameter sind wie die Zahl der CD4-positiven Zellen; beide Parameter liefern darüber hinaus zusätzliche Infromation. Die Bestimmung der Meßgrößen erfolgt aus Serum (Neopterin und [beta]2-Mikroglobulin) oder Urin (Neopterin), wodurch das Risiko einer eventuellen HIV-1 Übertragung bei der Testdurchführung im Vergleich zur Bearbeitung von Vollblut, wie es zur Zellzählung benötigt wird, verringert wird. Auch wenn noch weitere Untersuchungen vor allem in Entwicklungsländern und in mit Zidovudin behandelten HIV-1 Infizierten notwendig sind, können Neopterin und [beta]2-Mikroglobulin als zusätzliche Parameter zur Abschätzung des AIDS-Risikos bei HIV-1 Infizierten empfohlen werden. Beide Meßgrößen sind auch dazu geeignet, die Bestimmung von CD4- positiven Zellen zu ersetzen, wenn die Möglichkeiten der Zellquantifizierung nicht gegeben sind.

The great majority of individuals with human immunodeficiency virus type 1 (HIV-1) infection presents with no signs or symptoms, or only lymphadenopathy. To initiate prophylactic measures in time it is necessary to establish risk criteria. CD4+ cell counts are significant predictors. Supplementary methods to improve the predictive information of CD4+ cell counts are still required. In addition, CD4+ cell counting is laborious, expensive, and restricted to specialized laboratories. Thus, there is also a place for more easily performed laboratory tests with similar predictive value as CD4+ cell counts. Neopterin and [beta]2-microglobulin levels proved to be significant predictors of AIDS risk in HIV-1 seropositives. The predictive value of both parameters is equal to CD4+ cell counts and both markers are significant joint predictors in addition to CD4+ cell counts. Measurement of the parameters is done in serum (neopterin and [beta]2-microglobulin) or urine (neopterin) specimens which reduces the risk of HIV-1 transmission compared to handling of whole-blood samples as it is required for cell counting. Although more studies are needed, especially in developing countries and in persons receiving zidovudine, it can be recommended to use neopterin and [beta]2-microglobulin as additional marker to estimate AIDS risk in HIV-1 seropositive individuals. Moreover, both markers may be useful for this purpose without CD4+ cell counts if cell counting is not available.
Erscheinungsjahr
Zeitschriftentitel
Infection
Band
19
Zeitschriftennummer
S2
Seite
S98-S102
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eISSN
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Fuchs D, Krämer A, Reibnegger G, et al. Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection. Infection. 1991;19(S2):S98-S102.
Fuchs, D., Krämer, A., Reibnegger, G., Werner, E. R., Dierich, M. P., Goedert, J. J., & Wachter, H. (1991). Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection. Infection, 19(S2), S98-S102. doi:10.1007/BF01644476
Fuchs, D., Krämer, A., Reibnegger, G., Werner, E. R., Dierich, M. P., Goedert, J. J., and Wachter, H. (1991). Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection. Infection 19, S98-S102.
Fuchs, D., et al., 1991. Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection. Infection, 19(S2), p S98-S102.
D. Fuchs, et al., “Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection”, Infection, vol. 19, 1991, pp. S98-S102.
Fuchs, D., Krämer, A., Reibnegger, G., Werner, E.R., Dierich, M.P., Goedert, J.J., Wachter, H.: Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection. Infection. 19, S98-S102 (1991).
Fuchs, Dietmar, Krämer, Alexander, Reibnegger, Gilbert, Werner, Ernst R., Dierich, M. P., Goedert, James J., and Wachter, Helmut. “Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection”. Infection 19.S2 (1991): S98-S102.
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13 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Enhanced MCR-ALS modeling of HPLC with fast scan fluorimetric detection second-order data for quantitation of metabolic disorder marker pteridines in urine.
Culzoni MJ, Mancha de Llanos A, De Zan MM, Espinosa-Mansilla A, Cañada-Cañada F, Muñoz de la Peña A, Goicoechea HC., Talanta 85(5), 2011
PMID: 21962655
Temporarily controlled HIV-1 replication after intravenous immunoglobulin treatment of Guillain-Barré syndrome.
Gisslén M, Fredman P, Fuchs D, Lekman A, Rosengren L., Scand J Infect Dis 37(11-12), 2005
PMID: 16308224
Saliva and inhibition of HIV-1 infection: molecular mechanisms.
Shugars DC, Sweet SP, Malamud D, Kazmi SH, Page-Shafer K, Challacombe SJ., Oral Dis 8 Suppl 2(), 2002
PMID: 12164652
Analysis of clinical AIDS-free interval after CD4+ cell counts fall below 200 x 10(6) L-1 in Japanese haemophiliacs infected with HIV-1.
Tatsunami S, Mimaya J, Meguro T, Kuwabara R, Yago N, Yamada K., Haemophilia 4(1), 1998
PMID: 9873864
Serum neopterin, beta2-microglobulin, soluble interleukin-2 receptors, and immunoglobulin levels in healthy adolescents.
Satoh T, Brown LM, Blattner WA, Maloney EM, Kurman CC, Nelson DL, Fuchs D, Wachter H, Tollerud DJ., Clin Immunol Immunopathol 88(2), 1998
PMID: 9714695
Activated Cellular Immunity in Chronic Hepatitis C.
Diez-Ruiz A, Norkrans G, Wejstal R, Weiland O, Tilz GP, Wachter H, Fuchs D., Hematology 1(1), 1996
PMID: 27406302
Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus.
Samsonov MY, Tilz GP, Egorova O, Reibnegger G, Balabanova RM, Nassonov EL, Nassonova VA, Wachter H, Fuchs D., Lupus 4(1), 1995
PMID: 7767335
Raised levels of tumour necrosis factor-alpha and neopterin, but not interferon-alpha, in serum of HIV-1-infected patients from Ethiopia.
Ayehunie S, Sonnerborg A, Yemane-Berhan T, Zewdie DW, Britton S, Strannegard O., Clin Exp Immunol 91(1), 1993
PMID: 8419084
Neopterin and opportunistic infections in HIV-infected patients.
Domingo P, Martínez E, Martínez C, Barrio J, Cadafalch J., Clin Investig 71(1), 1993
PMID: 8453262
Prognostic value of serum beta 2-microglobulin in HIV infection.
Pedreira J, Castro A, Pereiro C, Barbuzano C., Lancet 340(8815), 1992
PMID: 1353829

32 References

Daten bereitgestellt von Europe PubMed Central.

Three-year incidence of AIDS in five cohorts of HTLV-III-infected risk group members.
Goedert JJ, Biggar RJ, Weiss SH, Eyster ME, Melbye M, Wilson S, Ginzburg HM, Grossman RJ, DiGioia RA, Sanchez WC., Science 231(4741), 1986
PMID: 3003917
Long-term seropositivity for human T-lymphotropic virus type III in homosexual men without the acquired immunodeficiency syndrome: development of immunologic and clinical abnormalities. A longitudinal study.
Melbye M, Biggar RJ, Ebbesen P, Neuland C, Goedert JJ, Faber V, Lorenzen I, Skinhoj P, Gallo RC, Blattner WA., Ann. Intern. Med. 104(4), 1986
PMID: 3006568
Predictors of the acquired immunodeficiency syndrome developing in a cohort of seropositive homosexual men.
Polk BF, Fox R, Brookmeyer R, Kanchanaraksa S, Kaslow R, Visscher B, Rinaldo C, Phair J., N. Engl. J. Med. 316(2), 1987
PMID: 3024007

Goedert, J. Am. Med. Assoc. 257(), 1987
Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application.
Wachter H, Fuchs D, Hausen A, Reibnegger G, Werner ER., Adv Clin Chem 27(), 1989
PMID: 2667296
Neopterin as a marker for activated cell-mediated immunity: application in HIV infection.
Fuchs D, Hausen A, Reibnegger G, Werner ER, Dierich MP, Wachter H., Immunol. Today 9(5), 1988
PMID: 3076770
Thymotaxin, a chemotactic protein, is identical to beta 2-microglobulin.
Dargemont C, Dunon D, Deugnier MA, Denoyelle M, Girault JM, Lederer F, Le KH, Godeau F, Thiery JP, Imhof BA., Science 246(4931), 1989
PMID: 2683083
Synthesis of 2 -microglobulin by stimulated lymphocytes.
Bernier GM, Fanger MW., J. Immunol. 109(2), 1972
PMID: 4114828
Beta 2-microglobulin and immune activation.
Fuchs D, Hausen A, Reibnegger G, Werner ER, Felmayer GW, Wachter H., Clin. Chem. 35(10), 1989
PMID: 2507199
Elevated urinary neopterin levels in patients with the acquired immunodeficiency syndrome (AIDS). A preliminary report.
Wachter H, Fuchs D, Hausen A, Huber C, Knosp O, Reibnegger G, Spira TJ., Hoppe-Seyler's Z. Physiol. Chem. 364(9), 1983
PMID: 6629341
Neopterin levels correlating with the Walter Reed staging classification in human immunodeficiency virus (HIV) infection.
Fuchs D, Reibnegger G, Wachter H, Jaeger H, Popescu M, Kaboth W., Ann. Intern. Med. 107(5), 1987
PMID: 3662301
Neopterin estimation compared with the ratio of T-cell subpopulations in persons infected with human immunodeficiency virus-1.
Fuchs D, Banekovich M, Hausen A, Hutterer J, Reibnegger G, Werner ER, Gschnait FD, Dierich MP, Wachter H., Clin. Chem. 34(12), 1988
PMID: 3264225

Wachter, Deutsch. Med. Wochenschr. 113(), 1988
Serum neopterin changes in HIV-infected subjects: indicator of significant pathology, CD4 T cell changes, and the development of AIDS.
Melmed RN, Taylor JM, Detels R, Bozorgmehri M, Fahey JL., J. Acquir. Immune Defic. Syndr. 2(1), 1989
PMID: 2783972
Neopterin: a predictive marker of acquired immune deficiency syndrome in human immunodeficiency virus infection.
Kramer A, Wiktor SZ, Fuchs D, Milstien S, Gail MH, Yellin FJ, Biggar RJ, Wachter H, Kaufman S, Blattner WA., J. Acquir. Immune Defic. Syndr. 2(3), 1989
PMID: 2566673
Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection.
Fuchs D, Spira TJ, Hausen A, Reibnegger G, Werner ER, Felmayer GW, Wachter H., Clin. Chem. 35(8), 1989
PMID: 2635886
Serum neopterin levels as predictor of AIDS.
Bogner JR, Matuschke A, Heinrich B, Eberle E, Goebel FD., Klin. Wochenschr. 66(20), 1988
PMID: 2467041
The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1.
Fahey JL, Taylor JM, Detels R, Hofmann B, Melmed R, Nishanian P, Giorgi JV., N. Engl. J. Med. 322(3), 1990
PMID: 1967191

Krämer, 1990

Fuchs, Immunol. Letters 26(), 1990
Abnormally high concentrations of beta 2 microglobulin in acquired immunodeficiency syndrome (AIDS) patients.
Bhalla RB, Safai B, Mertelsmann R, Schwartz MK., Clin. Chem. 29(8), 1983
PMID: 6191887

Zolla-Pazner, J. Am. Med. Assoc. 251(), 1984
Urinary neopterin: an early marker of HIV infection.
Kofler H, Fuchs D, Hintner H, Wachter H, Fritsch P., Eur. J. Clin. Microbiol. 6(6), 1987
PMID: 3440464
Serum beta 2-microglobulin level increases in HIV infection: relation to seroconversion, CD4 T-cell fall and prognosis.
Hofmann B, Wang YX, Cumberland WG, Detels R, Bozorgmehri M, Fahey JL., AIDS 4(3), 1990
PMID: 1972020

Moss, Brit. Med. J. 296(), 1988
Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidine.
Jacobson MA, Abrams DI, Volberding PA, Bacchetti P, Wilber J, Chaisson RE, Crowe S, Howard W, Moss A., J. Infect. Dis. 159(6), 1989
PMID: 2566637

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Markers of risk in HIV-1.
Kramer A, Biggar RJ, Goedert JJ., N. Engl. J. Med. 322(26), 1990
PMID: 1971915
Association between serum neopterin concentrations and in vitro replicative capacity of HIV-1 isolates.
Fuchs D, Albert J, Asjo B, Fenyo EM, Reibnegger G, Wachter H., J. Infect. Dis. 160(4), 1989
PMID: 2794565
Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.
Fuchs D, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G, Dierich MP, Wachter H., J. Acquir. Immune Defic. Syndr. 2(2), 1989
PMID: 2495349

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