Urinary neopterin concentrations and T-cell subset data in HIV-1 infection

Reibnegger G, Fuchs D, Goedert JJ, Hausen A, Krämer A, Werner ER, Werner-Felmayer G, Dierich MP, Wachter H (1990)
Journal of Molecular Medicine 68(1): 43-48.

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Abstract
We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression.
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Reibnegger G, Fuchs D, Goedert JJ, et al. Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine. 1990;68(1):43-48.
Reibnegger, G., Fuchs, D., Goedert, J. J., Hausen, A., Krämer, A., Werner, E. R., Werner-Felmayer, G., et al. (1990). Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine, 68(1), 43-48.
Reibnegger, G., Fuchs, D., Goedert, J. J., Hausen, A., Krämer, A., Werner, E. R., Werner-Felmayer, G., Dierich, M. P., and Wachter, H. (1990). Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine 68, 43-48.
Reibnegger, G., et al., 1990. Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine, 68(1), p 43-48.
G. Reibnegger, et al., “Urinary neopterin concentrations and T-cell subset data in HIV-1 infection”, Journal of Molecular Medicine, vol. 68, 1990, pp. 43-48.
Reibnegger, G., Fuchs, D., Goedert, J.J., Hausen, A., Krämer, A., Werner, E.R., Werner-Felmayer, G., Dierich, M.P., Wachter, H.: Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine. 68, 43-48 (1990).
Reibnegger, Gilbert, Fuchs, Dietmar, Goedert, James J., Hausen, A., Krämer, Alexander, Werner, Ernst R., Werner-Felmayer, G., Dierich, M. P., and Wachter, Helmut. “Urinary neopterin concentrations and T-cell subset data in HIV-1 infection”. Journal of Molecular Medicine 68.1 (1990): 43-48.
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This data publication is cited in the following publications:
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1 Citation in Europe PMC

Data provided by Europe PubMed Central.

Correlation of the percentage of activated, CD3 + DR + lymphocytes to serum neopterin level in HIV-seropositive haemophiliacs.
Paloczi K, Ujhelyi E, Fuchs D, Mihalik R, Banhegyi D, Berkessy S, Salavecz V, Wachter H, Hollan SR, Fust G., Klin. Wochenschr. 69(4), 1991
PMID: 1710305

3 References

Data provided by Europe PubMed Central.

Neopterin as a marker for activated cell-mediated immunity: application in HIV infection.
Fuchs D, Hausen A, Reibnegger G, Werner ER, Dierich MP, Wachter H., Immunol. Today 9(5), 1988
PMID: 3076770
Generalization of the likelihood ratio concept for diagnostic tests with multiple diagnostic categories.
Reibnegger G, Zuchs D, Hausen A, Werner ER, Werner-Felmayer G, Wachter H., J Clin Epidemiol 42(5), 1989
PMID: 2732776
Evaluation of diagnostic tests with multiple diagnostic categories.
Birkett NJ., J Clin Epidemiol 41(5), 1988
PMID: 3367180

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