Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils

Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR (2008)
Journal of Negative Results in BioMedicine 7(1).

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It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both methylphenidate (MP) and handling have a positive effect on the dopaminergic fiber density in the prefrontal cortex (PFC) of early traumatized gerbils (Meriones unguiculatus). The current study was performed to investigate if enriched environment during MP application has an additional influence on the dopaminergic and GABAergic fiber densities in the PFC and amygdala in this animal model. Animals received a single early dose of methamphetamine (MA; 50 mg/kg; i.p.) on postnatal day (PD) 14, which is known to cause multiple changes in the subsequent development of several neurotransmitter systems including the dopaminergic systems, and were then treated with oral daily applications of MP (5 mg/kg) from PD30–60. Animals treated this way were either transferred to an enriched environment after weaning (on PD30) or were kept under impoverished rearing conditions. There was no effect of an enriched environment on the dopaminergic or GABAergic fiber density neither in the PFC nor in the amygdala. With regard to former studies these results underline the particular impact of MP in the treatment of ADHD.
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Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR. Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine. 2008;7(1).
Brummelte, S., Grund, T., Moll, G. H., Teuchert-Noodt, G., & Dawirs, R. R. (2008). Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine, 7(1).
Brummelte, S., Grund, T., Moll, G. H., Teuchert-Noodt, G., and Dawirs, R. R. (2008). Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine 7.
Brummelte, S., et al., 2008. Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine, 7(1).
S. Brummelte, et al., “Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils”, Journal of Negative Results in BioMedicine, vol. 7, 2008.
Brummelte, S., Grund, T., Moll, G.H., Teuchert-Noodt, G., Dawirs, R.R.: Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine. 7, (2008).
Brummelte, Susanne, Grund, Thorsten, Moll, Gunther H., Teuchert-Noodt, Gertraud, and Dawirs, Ralph R. “Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils”. Journal of Negative Results in BioMedicine 7.1 (2008).
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2 Citations in Europe PMC

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Yoon SY, dela Pena I, Kim SM, Woo TS, Shin CY, Son KH, Park H, Lee YS, Ryu JH, Jin M, Kim KM, Cheong JH., Arch. Pharm. Res. 36(1), 2013
PMID: 23371806
Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur. J. Pharmacol. 616(1-3), 2009
PMID: 19540225

48 References

Data provided by Europe PubMed Central.

Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors.
Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB., Nature 403(6767), 2000
PMID: 10659839
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
Brummelte S, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 114(5), 2007
PMID: 17195918
Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).
Dawirs RR, Teuchert-Noodt G, Nossoll M., Eur. J. Pharmacol. 327(2-3), 1997
PMID: 9200549
Ontogeny of the dopamine innervation in the nucleus accumbens of gerbils.
Lesting J, Neddens J, Teuchert-Noodt G., Brain Res. 1066(1-2), 2005
PMID: 16343448
Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters.
Moll GH, Hause S, Ruther E, Rothenberger A, Huether G., J Child Adolesc Psychopharmacol 11(1), 2001
PMID: 11322741
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
ADHD - beyond core symptoms. Not only a European perspective.
Rothenberger A, Dopfner M, Sergeant J, Steinhausen HC., 2004
Attention and behavioural problems of Finnish adolescents may be related to the family environment.
Hurtig T, Taanila A, Ebeling H, Miettunen J, Moilanen I., Eur Child Adolesc Psychiatry 14(8), 2005
PMID: 16341505
European clinical guidelines for hyperkinetic disorder -- first upgrade.
Taylor E, Dopfner M, Sergeant J, Asherson P, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Rothenberger A, Sonuga-Barke E, Steinhausen HC, Zuddas A., Eur Child Adolesc Psychiatry 13 Suppl 1(), 2004
PMID: 15322953
Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline.
Banaschewski T, Coghill D, Santosh P, Zuddas A, Asherson P, Buitelaar J, Danckaerts M, Dopfner M, Faraone SV, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke EJ, Taylor E., Eur Child Adolesc Psychiatry 15(8), 2006
PMID: 16680409
Differential environment alters ontogeny of dopamine innervation of the orbital prefrontal cortex in gerbils.
Neddens J, Brandenburg K, Teuchert-Noodt G, Dawirs RR., J. Neurosci. Res. 63(2), 2001
PMID: 11169631
Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex.
Marsteller DA, Gerasimov MR, Schiffer WK, Geiger JM, Barnett CR, Schaich Borg J, Scott S, Ceccarelli J, Volkow ND, Molina PE, Alexoff DL, Dewey SL., Neuropsychopharmacology 27(2), 2002
PMID: 12093590
The effects of neonatal handling on the development of the adrenocortical response to stress: implications for neuropathology and cognitive deficits in later life.
Meaney MJ, Mitchell JB, Aitken DH, Bhatnagar S, Bodnoff SR, Iny LJ, Sarrieau A., Psychoneuroendocrinology 16(1-3), 1991
PMID: 1961847
Effects of neonatal handling on the behavior and prolactin stress response in male and female rats at various ages and estrous cycle phases of females.
Severino GS, Fossati IA, Padoin MJ, Gomes CM, Trevizan L, Sanvitto GL, Franci CR, Anselmo-Franci JA, Lucion AB., Physiol. Behav. 81(3), 2004
PMID: 15135021

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